Efficacy of the Localized Aviation MOS Program in Ceiling Flight Category Forecasts

(1) Background: Flying in instrument meteorological conditions (IMC) carries an elevated risk of fatal outcome for general aviation (GA) pilots. For the typical GA flight, aerodrome-specific forecasts (Terminal Aerodrome Forecast (TAF), Localized Aviation Model Output Statistics Program (LAMP)) assist the airman in pre-determining whether a flight can be safely undertaken. While LAMP forecasts are more prevalent at GA-frequented aerodromes, the Federal Aviation Administration (FAA) recommends that this tool be used as supplementary to the TAF only. Herein, the predictive accuracy of LAMP for ceiling flight categories of visual flight rules (VFR) and instrument flight rules (IFR) was determined. (2) Methods: LAMP accuracy was evaluated for the period of July–December 2018 using aviation-specific probability of detection (PODA), false alarm ratio (FARA) and critical success scores (CSSA). Statistical differences were determined using Chi-Square tests. (3) Results: LAMP forecasts (n = 823) across 39 states were accrued. LAMP PODA for VFR (0.67) and IFR (0.78) exceeded (p \u3c 0.031) the corresponding TAF scores (0.57 and 0.56). For VFR, the LAMP showed a non-significant (p = 0.243) higher FARA (0.25) than the TAF (0.19). For IFR forecasts, the LAMP FARA was lower (p \u3c 0.001) (0.48 and 0.81, respectively). LAMP CSSA scores exceeded the TAF for VFR (p = 0.012) and IFR forecasts (p \u3c 0.001). (4) Conclusion: These findings support the greater integration of LAMP into pre-flight weather briefings

A Comparison of the Localized Aviation MOS Program (LAMP) and Terminal Aerodrome Forecast (TAF) Accuracy for General Aviation

Background. For general aviation (GA) pilots, operations in instrument meteorological conditions (IMC) carry an elevated risk of a fatal accident. As to whether a general aviation flight can be safely undertaken, aerodrome-specific forecasts (TAF, LAMP) provide guidance. Although LAMP forecasts are more common for GA-frequented aerodromes, nevertheless, the FAA recommends that for such aerodromes (and for which a TAF is not issued) the airman uses the TAF generated for the geographically closest airport for pre-flight weather evaluation. Herein, for non-TAF-issuing airports, the LAMP (sLAMP) predictive accuracy for visual (VFR) and instrument (IFR) flight rules flight category was determined. Method. sLAMP accuracy was evaluated over 12 months using the fractions of forecasts which were correct or false alarms. Statistical differences employed Chi-Square/Fisher Exact tests. Results. sLAMP forecasts (n=570) across 43 states were accrued. The fraction of correct sLAMP forecasts for VFR (0.53) and IFR (0.68) exceeded (p Conclusion. Our findings indicate the forecast superiority of the satellite-LAMP at non-TAF-issuing airports compared with the TAF generated at a proximate aerodrome. Practical Application. For non-TAF-issuing sLAMP airports, these findings argue for greater integration of the latter tool in pre-flight weather briefings for general aviation operations

Sibling Relationship Quality: Associations with Marital and Coparenting Subsystems

Marital relationships play an important role in family functioning and in the development of sibling relationships. From a family systems perspective, other subsystems within the family, such as coparenting interactions, could explain the effects of the marital relationship on sibling bonds. Specifically, the quality of the coparenting relationship may mediate the association between marital functioning and sibling relationship quality. The current study examined relationships between these three subsystems (marital, coparenting, and sibling) as self-reported by mothers, fathers, and children with siblings. As part of a larger project, families with a child aged 8 to 11 and at least one sibling (N = 75) completed the Dyadic Adjustment Scale and the Coparenting Scale (both completed by mother and father), as well as the Sibling Relationship Questionnaire (completed by target child). Results suggested that marital functioning is a significant predictor of functioning within the coparenting relationship. Predicted associations did not emerge between sibling relationship quality and marital or coparenting relationships, with minor exceptions, and the coparenting relationship did not mediate the association between marital and sibling relationship quality. Implications of the current findings and suggestions for future research are discussed

microRNA expression in acute myeloid leukaemia: New targets for therapy?

Recent studies have shown that short non-coding RNAs, known as microRNAs (miRNAs) and their dysregulation, are implicated in the pathogenesis of acute myeloid leukaemia (AML). This is due to their role in the control of gene expression in a variety of molecular pathways. Therapies involving miRNA suppression and replacement have been developed. The normalisation of expression and the subsequent impact on AML cells have been investigated for some miRNAs, demonstrating their potential to act as therapeutic targets. Focussing on miRs with therapeutic potential, we have reviewed those that have a significant impact on the aberrant biological processes associated with AML, and crucially, impact leukaemic stem cell survival. We describe six miRNAs in preclinical trials (miR-21, miR-29b, miR-126, miR-181a, miR-223 and miR-196b) and two miRNAs that are in clinical trials (miR-29 and miR-155). However none have been used to treat AML patients and greater efforts are needed to develop miRNA therapies that could benefit AML patients in the future

TORIS Data Preparation Guidelines

The objective of this manual is to present guidelines and procedures for the preparation of new data for the Tertiary Oil Recovery Information System (TORIS) data base. TORIS is an analytical system currently maintained by the Department of Energy's (DOE) Bartlesville Project Office. It uses an extensive field- and reservoir-level data base to evaluate the technical and economic recovery potential of specific crude oil reservoirs

Bioavailability of Cadmium in Inexpensive Jewelry

Objectives: We evaluated the bioavailability of Cd in 86 components of 57 jewelry items found to contain high levels of Cd (> 10,000 ppm) by X-ray fluorescence (XRF), using extractions that simulate mouthing or swallowing of jewelry items

Concert recording 2015-03-22

[Track 01]. Walking street ; [Track 02]. Pan man / Steve Erquiaga -- [Track 03]. Cherokee / Ray Noble -- [Track 04]. Wave / Antonio Caros Jobim -- [Track 05]. Alone together / Arthur Schwartz -- [Track 06]. Up jumped spring / Freddie Hubbard -- [Track 07]. Blues for Alice / Charlie Bird Parker -- [Track 08]. Stella by starlight / Victor Young ; solo arranged by Jared Guinn

The aggregation of cytochrome C may be linked to its flexibility during refolding

Large-scale expression of biopharmaceutical proteins in cellular hosts results in production of large insoluble mass aggregates. In order to generate functional product, these aggregates require further processing through refolding with denaturant, a process in itself that can result in aggregation. Using a model folding protein, cytochrome C, we show how an increase in final denaturant concentration decreases the propensity of the protein to aggregate during refolding. Using polarised fluorescence anisotropy, we show how reduced levels of aggregation can be achieved by increasing the period of time the protein remains flexible during refolding, mediated through dilution ratios. This highlights the relationship between the flexibility of a protein and its propensity to aggregate. We attribute this behaviour to the preferential urea-residue interaction, over self-association between molecules