An Independent Calibration of Stellar Ages: HST Observations of White Dwarfs at V=25

The white dwarf luminosity function of a stellar cluster will have a sharp truncation at a luminosity which is determined by the time since formation of the first white dwarfs in that cluster. Calculation of the dependence of this limiting luminosity on age requires relatively well-understood physics and is independent of stellar evolutionary models. Thus, measurement of the termination of the white dwarf luminosity function provides an independent method to determine the age of a cluster, and thereby to calibrate stellar evolutionary ages. We have obtained HST WFPC2 data in two open clusters, identified the white dwarf sequence, and proved the feasibility of this approach, by detecting white dwarfs to V=25. Much deeper data are feasible. From our present limited data, we show that degenerate cooling ages are not consistent with some published isochrone ages for clusters with ages of order 1Gyr.Comment: 5 pages plus 3 figures ps format, paper in press in MNRAS: previous attempt lost the tex

On N=8 attractors

We derive and solve the black hole attractor conditions of N=8 supergravity by finding the critical points of the corresponding black hole potential. This is achieved by a simple generalization of the symplectic structure of the special geometry to all extended supergravities with $N>2$. There are two solutions for regular black holes, one for 1/8 BPS ones and one for the non-BPS. We discuss the solutions of the moduli at the horizon for BPS attractors using N=2 language. An interpretation of some of these results in N=2 STU black hole context helps to clarify the general features of the black hole attractors.Comment: 15 page

The effect of stellar-mass black holes on the structural evolution of massive star clusters

We present the results of realistic N-body modelling of massive star clusters in the Magellanic Clouds, aimed at investigating a dynamical origin for the radius-age trend observed in these systems. We find that stellar-mass black holes, formed in the supernova explosions of the most massive cluster stars, can constitute a dynamically important population. If a significant number of black holes are retained (here we assume complete retention), these objects rapidly form a dense core where interactions are common, resulting in the scattering of black holes into the cluster halo, and the ejection of black holes from the cluster. These two processes heat the stellar component, resulting in prolonged core expansion of a magnitude matching the observations. Significant core evolution is also observed in Magellanic Cloud clusters at early times. We find that this does not result from the action of black holes, but can be reproduced by the effects of mass-loss due to rapid stellar evolution in a primordially mass segregated cluster.Comment: Accepted for publication in MNRAS Letters; 2 figures, 1 tabl

Technology transfer - A selected bibliography

Selected bibliography on technology transfe

The Inner Galaxy resolved at IJK using DENIS data

We present the analysis of three colour optical/near-infrared images, in IJK, taken for the DENIS project. The region considered covers 17.4 square deg and lies within |l|<5 deg, |b|<1.5 deg. The adopted methods for deriving photometry and astrometry in these crowded images, together with an analysis of the deficiencies nevertheless remaining, are presented. The numbers of objects extracted in I,J and K are 748000, 851000 and 659000 respectively, to magnitude limits of 17,15 and 13. 80% completeness levels typically fall at magnitudes 16, 13 and 10 respectively, fainter by about 2 magnitudes than the usual DENIS limits due to the crowded nature of these fields. A simple model to describe the disk contribution to the number counts is constructed, and parameters for the dust layer derived. We find that a formal fit of parameters for the dust plane, from these data in limited directions, gives a scalelength and scaleheight of 3.4+-1.0 kpc and 40+-5 pc respectively, and a solar position 14.0+-2.5 pc below the plane. This latter value is likely to be affected by localised dust asymmetries. We convolve a detailed model of the systematic and random errors in the photometry with a simple model of the Galactic disk and dust distribution, to simulate expected colour-magnitude diagrams. These are in good agreement with the observed diagrams, allowing us to isolate those stars from the inner disk and bulge. After correcting for local dust-induced asymmetries, we find evidence for longitude-dependent asymmetries in the distant J and K sources, consistent with the general predictions of some Galactic bar models. We consider complementary L-band observations in a second paper.Comment: 14 pages, 33 figures, LaTeX, MNRAS accepte

Inhibition of oncogenic transcription factor REL by the natural product derivative calafianin monomer 101 induces proliferation arrest and apoptosis in human B-lymphoma cell lines

Increased activity of transcription factor NF-κB has been implicated in many B-cell lymphomas. We investigated effects of synthetic compound calafianin monomer (CM101) on biochemical and biological properties of NF-κB. In human 293 cells, CM101 selectively inhibited DNA binding by overexpressed NF-κB subunits REL (human c-Rel) and p65 as compared to NF-κB p50, and inhibition of REL and p65 DNA binding by CM101 required a conserved cysteine residue. CM101 also inhibited DNA binding by REL in human B-lymphoma cell lines, and the sensitivity of several B-lymphoma cell lines to CM101-induced proliferation arrest and apoptosis correlated with levels of cellular and nuclear REL. CM101 treatment induced both phosphorylation and decreased expression of anti-apoptotic protein Bcl-XL, a REL target gene product, in sensitive B-lymphoma cell lines. Ectopic expression of Bcl-XL protected SUDHL-2 B-lymphoma cells against CM101-induced apoptosis, and overexpression of a transforming mutant of REL decreased the sensitivity of BJAB B-lymphoma cells to CM101-induced apoptosis. Lipopolysaccharide-induced activation of NF-κB signaling upstream components occurred in RAW264.7 macrophages at CM101 concentrations that blocked NF-κB DNA binding. Direct inhibitors of REL may be useful for treating B-cell lymphomas in which REL is active, and may inhibit B-lymphoma cell growth at doses that do not affect some immune-related responses in normal cells.R01 GM094551 - NIGMS NIH HHS; P50 GM067041 - NIGMS NIH HHS; GM094551 - NIGMS NIH HHS; R24 GM111625 - NIGMS NIH HHS; GM067041 - NIGMS NIH HH