3,685 research outputs found
And yet it moves: The dangers of artificially fixing the Milky Way center of mass in the presence of a massive Large Magellanic Cloud
Motivated by recent studies suggesting that the Large Magellanic Cloud (LMC)
could be significantly more massive than previously thought, we explore whether
the approximation of an inertial Galactocentric reference frame is still valid
in the presence of such a massive LMC. We find that previous estimates of the
LMC's orbital period and apocentric distance derived assuming a fixed Milky Way
are significantly shortened for models where the Milky Way is allowed to move
freely in response to the gravitational pull of the LMC. Holding other
parameters fixed, the fraction of models favoring first infall is reduced. Due
to this interaction, the Milky Way center of mass within the inner 50 kpc can
be significantly displaced in phase-space in a very short period of time that
ranges from 0.3 to 0.5 Gyr by as much as 30 kpc and 75 km/s. Furthermore, we
show that the gravitational pull of the LMC and response of the Milky Way are
likely to significantly affect the orbit and phase space distribution of tidal
debris from the Sagittarius dwarf galaxy (Sgr). Such effects are larger than
previous estimates based on the torque of the LMC alone. As a result, Sgr
deposits debris in regions of the sky that are not aligned with the present-day
Sgr orbital plane. In addition, we find that properly accounting for the
movement of the Milky Way around its common center of mass with the LMC
significantly modifies the angular distance between apocenters and tilts its
orbital pole, alleviating tensions between previous models and observations.
While these models are preliminary in nature, they highlight the central
importance of accounting for the mutual gravitational interaction between the
MW and LMC when modeling the kinematics of objects in the Milky Way and Local
Group.Comment: Accepted for publication in ApJ; 16 pages, 11 figure
The application of a Trous wave filtering and Monte Carlo analysis on SECIS 2001 solar eclipse observations
8000 images of the Solar corona were captured during the June 2001 total
Solar eclipse. New software for the alignment of the images and an automated
technique for detecting intensity oscillations using multi scale wavelet
analysis were developed. Large areas of the images covered by the Moon and the
upper corona were scanned for oscillations and the statistical properties of
the atmospheric effects were determined. The a Trous wavelet transform was used
for noise reduction and Monte Carlo analysis as a significance test of the
detections. The effectiveness of those techniques is discussed in detail.Comment: 17 pages, 8 figures, accepted by Solar Physics Journal for
publication in Topical Issue: "Frontiers in Solar Image Processing
The potency of the broad spectrum bacteriocin, bactofencin A, against staphylococci is highly dependent on primary structure, N-terminal charge and disulphide formation
Bactofencin A is a novel class IId bacteriocin, produced by the intestinal isolate Lactobacillus salivarius DPC6502, which has potent activity against medically significant pathogens including Staphylococcus aureus. This bacteriocin is unusual in that it has a highly cationic N terminus and a single disulfide bond between Cys7 and Cys22, resulting in a large C terminal loop. In this study, a library of synthetic bactofencin A variants were screened against the mastitis isolate, S. aureus DPC5246, to identify key residues responsible for activity. It was apparent that substituting either cysteine of the disulfide bond with either serine or alanine significantly reduced the activity of the bacteriocin, confirming the importance of the C terminal loop. Substituting N terminal amino acids with alanine had no effect on activity, whereas sequential removal of the N terminal positively charged residues resulted in an increasingly inactive peptide. A complete (synthetic) alanine scanning analysis revealed that the residues between Val9 and Gly17 were most affected by substitution suggesting that this area has a major influence on the potency of the bacteriocin. Substituting residues in the loop region between Cys7 and Cys22 for D-amino acid equivalents had a more detrimental effect on activity than L-alanine substitutions. Specifically Y10A, N11A, P15A and T16A are active at 4, 16, 1 and 16 μM respectively while their D equivalents were inactive at 1000 μM, the highest concentration tested. Ultimately, this study identifies the critical features in the primary structure of the bacteriocin which gives it such potent activity against pathogenic staphylococci
Quantum Fluctuations Driven Orientational Disordering: A Finite-Size Scaling Study
The orientational ordering transition is investigated in the quantum
generalization of the anisotropic-planar-rotor model in the low temperature
regime. The phase diagram of the model is first analyzed within the mean-field
approximation. This predicts at a phase transition from the ordered to
the disordered state when the strength of quantum fluctuations, characterized
by the rotational constant , exceeds a critical value . As a function of temperature, mean-field theory predicts a range of
values of where the system develops long-range order upon cooling, but
enters again into a disordered state at sufficiently low temperatures
(reentrance). The model is further studied by means of path integral Monte
Carlo simulations in combination with finite-size scaling techniques,
concentrating on the region of parameter space where reentrance is predicted to
occur. The phase diagram determined from the simulations does not seem to
exhibit reentrant behavior; at intermediate temperatures a pronounced increase
of short-range order is observed rather than a genuine long-range order.Comment: 27 pages, 8 figures, RevTe
Survival and major neurodevelopmental impairment in extremely low gestational age newborns born 1990–2000: a retrospective cohort study
<p>Abstract</p> <p>Background</p> <p>It is important to determine if rates of survival and major neurodevelopmental impairment in extremely low gestational age newborns (ELGANs; infants born at 23–27 weeks gestation) are changing over time.</p> <p>Methods</p> <p>Study infants were born at 23 to 27 weeks of gestation without congenital anomalies at a tertiary medical center between July 1, 1990 and June 30, 2000, to mothers residing in a thirteen-county region in North Carolina. Outcomes at one year adjusted age were compared for two epochs of birth: epoch 1, July 1, 1990 to June 30, 1995; epoch 2, July 1, 1995 to June 30, 2000. Major neurodevelopmental impairment was defined as cerebral palsy, Bayley Scales of Infant Development Mental Developmental Index more than two standard deviations below the mean, or blindness.</p> <p>Results</p> <p>Survival of ELGANs, as a percentage of live births, was 67% [95% confidence interval: (61, 72)] in epoch 1 and 71% (65, 75) in epoch 2. Major neurodevelopmental impairment was present in 20% (15, 27) of survivors in epoch 1 and 14% (10, 20) in epoch 2. When adjusted for gestational age, survival increased [odds ratio 1.5 (1.0, 2.2), p = .03] and major neurodevelopmental impairment decreased [odds ratio 0.54 (0.31, 0.93), p = .02] from epoch 1 to epoch 2.</p> <p>Conclusion</p> <p>The probability of survival increased while that of major neurodevelopmental impairment decreased during the 1990's in this regionally based sample of ELGANs.</p
Figuring Out Gas & Galaxies In Enzo (FOGGIE). IV. The Stochasticity of Ram Pressure Stripping in Galactic Halos
We study ram pressure stripping in simulated Milky Way-like halos at z>=2
from the Figuring Out Gas & Galaxies In Enzo (FOGGIE) project. These
simulations reach exquisite resolution in their circumgalactic medium (CGM) gas
owing to FOGGIE's novel refinement scheme. The CGM of each halo spans a wide
dynamic range in density and velocity over its volume---roughly 6 dex and 1000
km/s, respectively---translating into a 5 dex range in ram pressure imparted to
interacting satellites. The ram pressure profiles of the simulated CGM are
highly stochastic, owing to kpc-scale variations of the density and velocity
fields of the CGM gas. As a result, the efficacy of ram pressure stripping
depends strongly on the specific path a satellite takes through the CGM. The
ram-pressure history of a single satellite is generally unpredictable and not
well correlated with its approach vector with respect to the host galaxy. The
cumulative impact of ram pressure on the simulated satellites is dominated by
only a few short strong impulses---on average, 90% of the total surface
momentum gained through ram pressure is imparted in 20% or less of the total
orbital time. These results reveal an erratic mode of ram pressure stripping in
Milky-Way like halos at high redshift---one that is not captured by a smooth
spherically-averaged model of the circumgalactic medium.Comment: 18 pages, 10 figures. Submitted to Ap
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