313 research outputs found
Global Charges in Chern-Simons theory and the 2+1 black hole
We use the Regge-Teitelboim method to treat surface integrals in gauge
theories to find global charges in Chern-Simons theory. We derive the affine
and Virasoro generators as global charges associated with symmetries of the
boundary. The role of boundary conditions is clarified. We prove that for
diffeomorphisms that do not preserve the boundary there is a classical
contribution to the central charge in the Virasoro algebra. The example of
anti-de Sitter 2+1 gravity is considered in detail.Comment: Revtex, no figures, 26 pages. Important changes introduced. One
section added
Semi-infinite Throat as the End-state Geometry of two-dimensional Black Hole Evaporation
We study a modified two-dimensional dilaton gravity theory which is exactly
solvable in the semiclassical approximation including back-reaction. The vacuum
solutions of this modified theory are asymptotically flat static space-times.
Infalling matter forms a black hole if its energy is above a certain threshold.
The black hole singularity is initially hidden behind a timelike apparent
horizon. As the black hole evaporates by emitting Hawking radiation, the
singularity meets the shrinking horizon in finite retarded time to become
naked. A natural boundary condition exists at the naked singularity such that
for general infalling matter-configuration the evaporating black hole
geometries can be matched continuously to a unique static end-state geometry.
This end-state geometry is asymptotically flat at its right spatial infinity,
while its left spatial infinity is a semi-infinite throat extending into the
strong coupling region.Comment: Tex + compressed uuencoded ps version with one figure included, 11
High Energy Neutrinos from Quasars
We review and clarify the assumptions of our basic model for neutrino
production in the cores of quasars, as well as those modifications to the model
subsequently made by other workers. We also present a revised estimate of the
neutrino background flux and spectrum obtained using more recent empirical
studies of quasars and their evolution. We compare our results with other
thoeretical calculations and experimental upper limits on the AGN neutrino
background flux. We also estimate possible neutrino fluxes from the jets of
blazars detected recently by the EGRET experiment on the Compton Gamma Ray
Observatory. We discuss the theoretical implications of these estimates.Comment: 14 pg., ps file (includes figures), To be published in Space Science
Review
M-Theory as a Holographic Field Theory
We suggest that M-theory could be non-perturbatively equivalent to a local
quantum field theory. More precisely, we present a ``renormalizable'' gauge
theory in eleven dimensions, and show that it exhibits various properties
expected of quantum M-theory, most notably the holographic principle of
't~Hooft and Susskind. The theory also satisfies Mach's principle: A
macroscopically large space-time (and the inertia of low-energy excitations) is
generated by a large number of ``partons'' in the microscopic theory. We argue
that at low energies in large eleven dimensions, the theory should be
effectively described by eleven-dimensional supergravity. This effective
description breaks down at much lower energies than naively expected, precisely
when the system saturates the Bekenstein bound on energy density. We show that
the number of partons scales like the area of the surface surrounding the
system, and discuss how this holographic reduction of degrees of freedom
affects the cosmological constant problem. We propose the holographic field
theory as a candidate for a covariant, non-perturbative formulation of quantum
M-theory.Comment: 27 pp. v2: typos corrected; a small paragraph on naturalness of small
cosmological constant in four dimensions added at end of sect 5.1; final
version to appear in Phys. Rev.
A novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata
Teneurin C-terminal associated peptide (TCAP) is an ancient bioactive peptide that is highly conserved in metazoans. TCAP administration reduces cellular and behavioural stress in vertebrate and urochordate models, yet despite numerous studies in higher animals, there is limited knowledge of its role in invertebrates. In particular, there are no studies on TCAP’s effects on the heart of any metazoan, which is a critical organ in the stress response. We used the Sydney rock oyster (SRO) as an invertebrate model to investigate a potential role for sroTCAP in regulating cardiac activity, including during stress. sroTCAP is localized to the neural innervation network of the SRO heart, and suggested binding with various heart proteins related to metabolism and stress, including SOD, GAPDH and metabotropic glutamate receptor. Intramuscular injection of sroTCAP (10 pmol) significantly altered the expression of heart genes that are known to regulate remodelling processes under different conditions, and modulated several gene families responsible for stress mitigation. sroTCAP (1 and 10 pmol) was shown to cause transient bradycardia (heart rate was reduced by up to 63% and for up to 40 min post-administration), indicative of an unstressed state. In summary, this study has established a role for a TCAP in the regulation of cardiac activity through modulation of physiological and molecular components associated with energy conservation, stress and adaptation. This represents a novel function for TCAP and may have implications for higher-order metazoans
SO(2N) (0,2) SCFT and M Theory on
We study M theory on AdS_7 \times \RP^4 corresponding to 6 dimensional
SO(2N) superconformal field theory on a circle which becomes 5
dimensional super Yang-Mills theory at low energies. For SU(N) (0,2) theory, a
wrapped D4 brane on which is connected to a D4 brane on the boundary of
by N fundamental strings can be interpreted as baryon vertex. For
SO(2N) (0,2) theory, by using the property of homology of \RP^4, we classify
various wrapping branes. Then we consider particles, strings, twobranes, domain
walls and the baryon vertex in Type IIA string theory.Comment: 20 papges, The discussion on N=8 3D SCFT is corrected. Minor
corrections, Added acknowledgment
Multiple Pathway-Based Genetic Variations Associated with Tobacco Related Multiple Primary Neoplasms
BACKGROUND: In order to elucidate a combination of genetic alterations that drive tobacco carcinogenesis we have explored a unique model system and analytical method for an unbiased qualitative and quantitative assessment of gene-gene and gene-environment interactions. The objective of this case control study was to assess genetic predisposition in a biologically enriched clinical model system of tobacco related cancers (TRC), occurring as Multiple Primary Neoplasms (MPN). METHODS: Genotyping of 21 candidate Single Nucleotide Polymorphisms (SNP) from major metabolic pathways was performed in a cohort of 151 MPN cases and 210 cancer-free controls. Statistical analysis using logistic regression and Multifactor Dimensionality Reduction (MDR) analysis was performed for studying higher order interactions among various SNPs and tobacco habit. RESULTS: Increased risk association was observed for patients with at least one TRC in the upper aero digestive tract (UADT) for variations in SULT1A1 Arg²¹³His, mEH Tyr¹¹³His, hOGG1 Ser³²⁶Cys, XRCC1 Arg²⁸⁰His and BRCA2 Asn³⁷²His. Gene-environment interactions were assessed using MDR analysis. The overall best model by MDR was tobacco habit/p53(Arg/Arg)/XRCC1(Arg³⁹⁹His)/mEH(Tyr¹¹³His) that had highest Cross Validation Consistency (8.3) and test accuracy (0.69). This model also showed significant association using logistic regression analysis. CONCLUSION: This is the first Indian study on a multipathway based approach to study genetic susceptibility to cancer in tobacco associated MPN. This approach could assist in planning additional studies for comprehensive understanding of tobacco carcinogenesis
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