Laser microscopy of tunneling magnetoresistance in manganite grain-boundary junctions

Using low-temperature scanning laser microscopy we directly image electric transport in a magnetoresistive element, a manganite thin film intersected by a grain boundary (GB). Imaging at variable temperature allows reconstruction and comparison of the local resistance vs temperature for both, the manganite film and the GB. Imaging at low temperature also shows that the GB switches between different resistive states due to the formation and growth of magnetic domains along the GB. We observe different types of domain wall growth; in most cases a domain wall nucleates at one edge of the bridge and then proceeds towards the other edge.Comment: 5 pages, 4 figures; submitted to Phys. Rev. Let

Prevention of coronary microvascular obstruction by addressing ischemia reperfusion injury-part a

Most recently, substantial research efforts were directed to the treatment and prevention of coronary microvascular obstruction (CMVO) by targeting various mechanisms involved in its multifactorial pathophysiology. Among other strategies, antiplatelets and vasodilators were tested in order to reduce thrombus burden and coronary vasospasm potentially resulting in enhanced myocardial perfusion. Furthermore, the impact of intensified statin therapy was evaluated in numerous investigations. Although most of these studies failed to convincingly prove beneficial effects regarding CMVO, especially antiplatelets and statins are indispensable cornerstones of post-infarction medical therapy. This chapter discusses the scientific evidence and guideline recommendations for the use of antiplatelets, statins, and vasodilators in patients with myocardial infarction with a particular focus on their efficacy to treat or prevent CMVO

First-principles study of (BiScO3){1-x}-(PbTiO3){x} piezoelectric alloys

We report a first-principles study of a class of (BiScO3)_{1-x}-(PbTiO3)_x (BS-PT) alloys recently proposed by Eitel et al. as promising materials for piezoelectric actuator applications. We show that (i) BS-PT displays very large structural distortions and polarizations at the morphotropic phase boundary (MPB) (we obtain a c/a of ~1.05-1.08 and P_tet of ~1.1 C/m^2); (ii) the ferroelectric and piezoelectric properties of BS-PT are dominated by the onset of hybridization between Bi/Pb-6p and O-2p orbitals, a mechanism that is enhanced upon substitution of Pb by Bi; and (iii) the piezoelectric responses of BS-PT and Pb(Zr_{1-x}Ti_x)O3 (PZT) at the MPB are comparable, at least as far as the computed values of the piezoelectric coefficient d_15 are concerned. While our results are generally consistent with experiment, they also suggest that certain intrinsic properties of BS-PT may be even better than has been indicated by experiments to date. We also discuss results for PZT that demonstrate the prominent role played by Pb displacements in its piezoelectric properties.Comment: 6 pages, with 3 postscript figures embedded. Uses REVTEX and epsf macros. Also available at http://www.physics.rutgers.edu/~dhv/preprints/ji_bi/index.htm

Cosmological implications of the KATRIN experiment

The upcoming Karlsruhe Tritium Neutrino (KATRIN) experiment will put unprecedented constraints on the absolute mass of the electron neutrino, \mnue. In this paper we investigate how this information on \mnue will affect our constraints on cosmological parameters. We consider two scenarios; one where \mnue=0 (i.e., no detection by KATRIN), and one where \mnue=0.3eV. We find that the constraints on \mnue from KATRIN will affect estimates of some important cosmological parameters significantly. For example, the significance of $n_s<1$ and the inferred value of $\Omega_\Lambda$ depend on the results from the KATRIN experiment.Comment: 13 page

Neutrino oscillations with disentanglement of a neutrino from its partners

We bring attention to the fact that in order to understand existing data on neutrino oscillations, and to design future experiments, it is imperative to appreciate the role of quantum entanglement. Once this is accounted for, the resulting energy-momentum conserving phenomenology requires a single new parameter related to disentanglement of a neutrino from its partners. This parameter may not be CP symmetric. We illustrate the new ideas, with potentially measurable effects, in the context of a novel experiment recently proposed by Gavrin, Gorbachev, Veretenkin, and Cleveland. The strongest impact of our ideas is on the resolution of various anomalies in neutrino oscillations and on neutrino propagation in astrophysical environments.Comment: 6 page

Anaerobic metabolism of Foraminifera thriving below the seafloor

Foraminifera are single-celled eukaryotes (protists) of large ecological importance, as well as environmental and paleoenvironmental indicators and biostratigraphic tools. In addition, they are capable of surviving in anoxic marine environments where they represent a major component of the benthic community. However, the cellular adaptations of Foraminifera to the anoxic environment remain poorly constrained. We sampled an oxic-anoxic transition zone in marine sediments from the Namibian shelf, where the genera Bolivina and Stainforthia dominated the Foraminifera community, and use metatranscriptomics to characterize Foraminifera metabolism across the different geochemical conditions. Relative Foraminifera gene expression in anoxic sediment increased an order of magnitude, which was confirmed in a 10-day incubation experiment where the development of anoxia coincided with a 20-40-fold increase in the relative abundance of Foraminifera protein encoding transcripts, attributed primarily to those involved in protein synthesis, intracellular protein trafficking, and modification of the cytoskeleton. This indicated that many Foraminifera were not only surviving but thriving, under the anoxic conditions. The anaerobic energy metabolism of these active Foraminifera was characterized by fermentation of sugars and amino acids, fumarate reduction, and potentially dissimilatory nitrate reduction. Moreover, the gene expression data indicate that under anoxia Foraminifera use the phosphogen creatine phosphate as an ATP store, allowing reserves of high-energy phosphate pool to be maintained for sudden demands of increased energy during anaerobic metabolism. This was co-expressed alongside genes involved in phagocytosis and clathrin-mediated endocytosis (CME). Foraminifera may use CME to utilize dissolved organic matter as a carbon and energy source, in addition to ingestion of prey cells via phagocytosis. These anaerobic metabolic mechanisms help to explain the ecological success of Foraminifera documented in the fossil record since the Cambrian period more than 500 million years ago

Extending the aridity record of the Southwest Kalahari: current problems and future perspectives

An extensive luminescence-based chronological framework has allowed the reconstruction of expansions and contractions of the Kalahari Desert over the last 50 ka. However, this chronology is largely based on near-surface pits and sediment exposures. These are the points on the landscape most prone to reactivation and resetting of the luminescence dating ‘clock’. This is proving to be a limiting feature for extending palaeoenvironmental reconstructions further back in time. One way to obviate this is to sample desert marginal areas that only become active during significant arid phases. An alternative is to find and sample deep stratigraphic exposures. The Mamatwan manganese mine at Hotazel in the SW Kalahari meets both these criteria. Luminescence dating of this site shows the upper sedimentary unit to span at least the last 60 ka with tentative age estimates from underlying cemented aeolian units dating back to the last interglacial and beyond. Results from Mamatwan are comparable to new and previously published data from linear dunes in the SW Kalahari but extend back much further. Analysis of the entire data set of luminescence ages for the SW Kalahari brings out important inferences that suggest that different aeolian forms (1) have been active over different time scales in the past, (2) have different sensitivities to environmental changes and (3) have different time scales over which they record and preserve the palaeoenvironmental record. This implies that future optically stimulated luminescence work and palaeoenvironmental reconstructions must consider both site location and its relationship to desert margins and sediment depositional styles, so that the resolution and duration of the aridity record can be optimally understood

Novel cell types, neurosecretory cells, and body plan of the early-diverging metazoan Trichoplax adhaerens.

BACKGROUND: Trichoplax adhaerens is the best-known member of the phylum Placozoa, one of the earliest-diverging metazoan phyla. It is a small disk-shaped animal that glides on surfaces in warm oceans to feed on algae. Prior anatomical studies of Trichoplax revealed that it has a simple three-layered organization with four somatic cell types. RESULTS: We reinvestigate the cellular organization of Trichoplax using advanced freezing and microscopy techniques to identify localize and count cells. Six somatic cell types are deployed in stereotyped positions. A thick ventral plate, comprising the majority of the cells, includes ciliated epithelial cells, newly identified lipophil cells packed with large lipid granules, and gland cells. Lipophils project deep into the interior, where they alternate with regularly spaced fiber cells whose branches contact all other cell types, including cells of the dorsal and ventral epithelium. Crystal cells, each containing a birefringent crystal, are arrayed around the rim. Gland cells express several proteins typical of neurosecretory cells, and a subset of them, around the rim, also expresses an FMRFamide-like neuropeptide. CONCLUSIONS: Structural analysis of Trichoplax with significantly improved techniques provides an advance in understanding its cell types and their distributions. We find two previously undetected cell types, lipohil and crystal cells, and an organized body plan in which different cell types are arranged in distinct patterns. The composition of gland cells suggests that they are neurosecretory cells and could control locomotor and feeding behavior

Statistical Analysis of Different Muon-antineutrino->Electron-antineutrino Searches

A combined statistical analysis of the experimental results of the LSND and KARMEN \numubnueb oscillation search is presented. LSND has evidence for neutrino oscillations that is not confirmed by the KARMEN experiment. This joint analysis is based on the final likelihood results for both data sets. A frequentist approach is applied to deduce confidence regions. At a combined confidence level of 36%, there is no area of oscillation parameters compatible with both experiments. For the complementary confidence of 1-0.36=64%, there are two well defined regions of oscillation parameters (sin^2(2th),Dm^2) compatible with both experiments.Comment: 25 pages, including 10 figures, submitted to Phys. Rev.