Alien Registration- Dubay, Joseph D. (Van Buren, Aroostook County)

https://digitalmaine.com/alien_docs/33363/thumbnail.jp

Today's Children, Tomorrow's America: Six Experts Face the Facts

Compiles essays about trends in family structure; how federal, state, and local budget deficits and projected cuts affect child poverty rates and health; and their long-term implications of reduced investment in children. Includes policy recommendations

DIFFERENTIAL DETECTION OF TERRITORIAL AND NON-TERRITORIAL GREATER SANDHILL CRANES IN SUMMER

Abundance estimates allow wildlife managers to make informed management decisions, but differential detectability of individuals can lead to biased estimates of abundance. Our objective was to quantify detectability for non-territorial and territorial sandhill cranes (Grus canadensis tabida) during summer. We hypothesized that territorial sandhill cranes would be detected more often than non-territorial cranes. In 2009, 3 wetland areas were surveyed 2 days per week during the nesting season near Briggsville, Wisconsin. We created capture histories for color-marked territorial (n = 52) and color-marked nonterritorial cranes (n = 23) and used the Huggins closed capture model in program MARK to estimate detection probability and abundance for each group. A priori models were developed that explained daily crane detection over the sampling period using distance from road, territorial status, observation event, and time of season as variables. The best approximating model included the variables territorial status and observation event (AICc weight = 0.92). Probability of detection was higher for territorial (0.11, 95% CI = 0.08-0.14) than for non-territorial ( 0.03, 95% CI = 0.01-0.07) sandhill cranes. In subsequent observation events, detection probability almost doubled to 0.18 (95% CI = 0.17-0.20) for territorial cranes, and almost tripled to 0.11 (95% CI = 0.09-0.14) for non-territorial cranes. Potential reasons for differential detection during subsequent observations include differing degrees of movement by birds and/or an observer effect in which the ability to observe birds or the perception by technicians of birds increased over time

To What Extent Does Text Simplification Entail a More Optimized Comprehension in Human-Oriented CNLs?

International audienceThe main goal of the current study is to develop a new cockpit controlled language for future Airbus aircraft by using psycholinguistic testing to optimize pilot comprehension. Pilots are aided by cockpit messages in order to deal with different situations during aircraft operations. The current controlled languages used on the Airbus aircraft have been carefully constructed to avoid ambiguity, inaccuracy, inconsistency, and inadequacy (Spaggiari, Beaujard, Cannesson (2003)) in order to ensure the safety of the navigation, operational needs, and the adaptability of the human-computer interaction to different situations in the cockpit. However, this controlled language has several limitations, mostly due to small screen sizes (limited number of words and sentences) and is highly codified (non-conforming to natural language syntax, color-coded and so on) so that it requires prior pilot training in order to achieve fluency. As future cockpit design is under construction, we might be looking at a different flexibility margin. Our experimentation plan is to go against the tide of common CNL (Controlled Natural Language) construction, in the sense that we will not be taking natural language and simplifying it, but rather taking a highly controlled codified language (therefore theoretically most simple) and " complexifying " it (bring it closer to natural language: theoretically most complex) in order to make it more accessible, and limit prior training needs

Theory of superconductivity of carbon nanotubes and graphene

We present a new mechanism of carbon nanotube superconductivity that originates from edge states which are specific to graphene. Using on-site and boundary deformation potentials which do not cause bulk superconductivity, we obtain an appreciable transition temperature for the edge state. As a consequence, a metallic zigzag carbon nanotube having open boundaries can be regarded as a natural superconductor/normal metal/superconductor junction system, in which superconducting states are developed locally at both ends of the nanotube and a normal metal exists in the middle. In this case, a signal of the edge state superconductivity appears as the Josephson current which is sensitive to the length of a nanotube and the position of the Fermi energy. Such a dependence distinguishs edge state superconductivity from bulk superconductivity.Comment: 5 pages, 2 figure

What drives amyloid molecules to assemble into oligomers and fibrils?

We develop a general theory for three states of equilibrium of amyloid peptides: the monomer, oligomer, and fibril. We assume that the oligomeric state is a disordered micelle-like collection of a few peptide chains held together loosely by hydrophobic interactions into a spherical hydrophobic core. We assume that fibrillar amyloid chains are aligned and further stabilized by `steric zipper' interactions -- hydrogen bonding and steric packing, in addition to specific hydrophobic sidechain contacts. The model makes a broad set of predictions, consistent with experiments: (i) Similar to surfactant micellization, amyloid oligomerization should increase with bulk peptide concentration. (ii) The onset of fibrillization limits the concentration of oligomers in the solution. (iii) The average fibril length \emph{vs.} monomer concentration agrees with data on $\alpha$-synuclein, (iv) Full fibril length distributions follow those of $\alpha$-synuclein, (v) Denaturants should `melt out' fibrils, and (vi) Added salt should stabilize fibrils by reducing repulsions between amyloid peptide chains. Interestingly, small changes in solvent conditions can: (a) tip the equilibrium balance between oligomer and fibril, and (b) cause large changes in rates, through effects on the transition-state barrier. This model may provide useful insights into the physical processes underlying amyloid diseases

Autophagosome-based strategy to monitor apparent tumor-specific CD8 T cells in patients with prostate cancer

The immune system plays an essential role in eradicating cancer in concert with various treatment modalities. In the absence of autologous tumor material, no standardized method exists to assess T cell responses against the many antigens that may serve as cancer rejection antigens. Thus, development of methods to screen for therapy-induced anti-tumor responses is a high priority that could help tailor therapy. Here we tested whether a tumor-derived antigen source called DRibbles®, which contain a pool of defective ribosomal products (DRiPs), long-lived and short-lived proteins (SLiPs) and danger-associated molecular patterns (DAMPs), can be used to identify tumor-associated antigen (TAA)-specific responses in patients before or after immunotherapy treatment. Protein content, gene expression and non-synonymous – single nucleotide variants (ns-SNVs) present in UbiLT3 DRibbles were compared with prostate adenocarcinomas and the prostate GVAX vaccine cell lines (PC3/LNCaP). UbiLT3 DRibbles were found to share proteins, as well as match tumor sequences for ns-SNVs with prostate adenocarcinomas and with the cell lines PC3 and LNCaP. UbiLT3 DRibbles were used to monitor anti-tumor responses in patients vaccinated with allogeneic prostate GVAX. UbiLT3-DRibble-reactive CD8+ T-cell responses were detected in post-vaccine PBMC of 6/12 patients (range 0.85–22% of CD8+ cells) after 1 week in vitro stimulation (p = 0.007 vs. pre-vaccine). In conclusion, a cancer-derived autophagosome-enriched preparation, packaging over 100 proteins over-expressed in prostate cancer into microvesicles containing DAMPs, could be used to identify CD8+ T cells in peripheral blood from patients after prostate GVAX vaccination and may represent a general method to monitor anti-cancer T cell responses following immunotherapy

Risk Factors for Urinary Complications After Renal Transplantation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73788/1/j.1600-6143.2007.01790.x.pd

The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus

Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting that FIV and human immunodeficiency virus (HIV) share a common mechanism of infection involving an interaction between the virus and a member of the seven transmembrane domain superfamily of molecules. This article reviews the evidence for the involvement of chemokine receptors in FIV infection and contrasts these findings with similar studies on the primate lentiviruses HIV and SIV (simian immunodeficiency virus)

Late local recurrence of dermatofibrosarcoma protuberans in the skin of female breast

Dermatofibrosarcoma protuberans (DFSP) of the breast is exceptionally obscure and late local recurrence of this entity on this site is even more uncommon. We describe such a case in a 48-year-old woman, who at the age of 35 had a DFSP excised from her right breast. Thirteen years later, she developed an ovoid mass in her right breast over the postsurgical scar area. Wide local excision of the tumor with generous tissue margin was performed and microscopic and immunohistochemical findings established the diagnosis of recurrent DFSP. No further treatment was administered and she remains well 18 months later, without tumor recurrence. We report an exceptionally rare case of local recurrence of DFSP in the female breast and discuss in detail the diagnostic and therapeutic implications of this pathology