Glycogen and its metabolism: some new developments and old themes

Glycogen is a branched polymer of glucose that acts as a store of energy in times of nutritional sufficiency for utilization in times of need. Its metabolism has been the subject of extensive investigation and much is known about its regulation by hormones such as insulin, glucagon and adrenaline (epinephrine). There has been debate over the relative importance of allosteric compared with covalent control of the key biosynthetic enzyme, glycogen synthase, as well as the relative importance of glucose entry into cells compared with glycogen synthase regulation in determining glycogen accumulation. Significant new developments in eukaryotic glycogen metabolism over the last decade or so include: (i) three-dimensional structures of the biosynthetic enzymes glycogenin and glycogen synthase, with associated implications for mechanism and control; (ii) analyses of several genetically engineered mice with altered glycogen metabolism that shed light on the mechanism of control; (iii) greater appreciation of the spatial aspects of glycogen metabolism, including more focus on the lysosomal degradation of glycogen; and (iv) glycogen phosphorylation and advances in the study of Lafora disease, which is emerging as a glycogen storage disease

Bio-Energy Production from Anaerobic Digestion of Animal and Farm Wastes

Track II: Transportation and BiofuelsIncludes audio file (20 min.)US produces annually huge amount of animal and farm wastes (e.g. only cow manure in amount of about 1.8 billion tons). These wastes can be valuable source of renewable energy besides overcoming the environmental problems caused by them such as greenhouse gas effect of methane emission of 22 times worse than carbon dioxide, surface and ground water contamination, odor, dust, ammonia leaching, etc. In this project we systematically studied the process, kinetics, microorganisms interaction and population, and the effects of design and operating parameters on reactor design and scale up of cow manure digestion for bioenergy production and for wastes treatment by developing and implementing advanced imaging, visualization and computational techniques such as computational fluid dynamics (CFD), novel multiple radioactive particles tracking technique (MRPT), novel dual source computed tomography (DSCT), and microbiology imaging techniques. New design and conditions of anaerobic digesters that can reduce significantly the inactive volume and improve the digesters performance have been identified and recommended. In addition, for the first time, the energy produced has been related to the energy introduced in order to maximize the energy output while minimizing the energy input through the mixing power consumed. It is hoped that the findings will be applied in the field to promote bioenergy production and eliminate major environmental pollution problems