291 research outputs found
Contrasting responses of lizard occurrences to burrowing by a critically endangered seabird
Abstract
Seabirds are considered ecosystem engineers, because they facilitate ecosystem functioning (e.g., nutrient cycling), crucial for other marine and terrestrial species, including reptiles. However, studies of seabird-reptile interactions are limited. Here, we assessed the influence of the ‘Critically Endangered’ Whenua Hou Diving Petrel (Pelecanoides whenuahouensis) on the occurrence of two threatened skinks, Stewart Island green skink (Oligosoma aff. chloronoton) and southern grass skink (O. aff. polychroma). We surveyed skinks for 26 consecutive days at 51 sites with and 48 sites without Diving Petrel burrows in the dunes on Codfish Island (Whenua Hou), New Zealand. We used occupancy modelling to assess the influence of burrows on the occurrence of skinks, while accounting for other factors affecting occupancy (Ψ) and detection probabilities (p). Diving Petrel burrows had a contrasting effect on the occurrence of skinks. On average, Ψ̂ of Stewart Island green skinks was 114% higher at sites with burrows compared to sites without, while Ψ̂ of southern grass skinks was only 2% higher. Occurrence of both skinks was negatively influenced by the presence of the other skink species. On average p̂ were low: 0.013 and 0.038 for Stewart Island green and southern grass skinks, respectively. Stewart Island green skinks appear attracted to burrows, which might facilitate thermoregulation (i.e., shelter from temperature extremes). The larger Stewart Island green skinks may subsequently exclude the smaller southern grass skinks at burrows, causing the contrasting relationships. We suggest that these interspecific interactions should be considered when implementing conservation management, e.g., through the order of species reintroductions
Signatures of the disk-jet coupling in the Broad-line Radio Quasar 4C+74.26
Here we explore the disk-jet connection in the broad-line radio quasar
4C+74.26, utilizing the results of the multiwavelength monitoring of the
source. The target is unique in that its radiative output at radio wavelengths
is dominated by a moderately-beamed nuclear jet, at optical frequencies by the
accretion disk, and in the hard X-ray range by the disk corona. Our analysis
reveals a correlation (local and global significance of 96\% and 98\%,
respectively) between the optical and radio bands, with the disk lagging behind
the jet by days. We discuss the possible explanation for this,
speculating that the observed disk and the jet flux changes are generated by
magnetic fluctuations originating within the innermost parts of a truncated
disk, and that the lag is related to a delayed radiative response of the disk
when compared with the propagation timescale of magnetic perturbations along
relativistic outflow. This scenario is supported by the re-analysis of the
NuSTAR data, modelled in terms of a relativistic reflection from the disk
illuminated by the coronal emission, which returns the inner disk radius
. We discuss the global energetics in
the system, arguing that while the accretion proceeds at the Eddington rate,
with the accretion-related bolometric luminosity erg s , the jet total kinetic energy
erg s, inferred from the dynamical
modelling of the giant radio lobes in the source, constitutes only a small
fraction of the available accretion power.Comment: 9 pages and 6 figures, ApJ accepte
The Enzymatic Activity of Type 1 Iodothyronine Deiodinase (D1) is Low in Liver Hemangioma: A Preliminary Study
Type 1 iodothyronine deiodinase (D1) is a crucial enzyme which converts the prohormone thyroxine (T4) into active tri-iodothyronine (T3). There has been strong evidence that the metabolism of thyroid hormones is disturbed in some neoplastic tissues such as thyroid, renal, and breast cancer. However, there are few available data about D1 enzyme activity in benign tumors such as hemangioma, which is the most common primary liver tumor. Hence this study aimed to determine the enzymatic activity of D1 in hemangiomas in relation to healthy liver tissue. Seven tumors and healthy control tissues were obtained from patients who had liver resection due to hemangioma. The activity was assessed by measurement of radioactive iodine released by deiodination catalyzed by D1. It was found that D1 activity was significantly lower in the hemagiomas than in the healthy surrounding tissue (p = 0.0017). The results indicated that thyroid hormones play important roles not only in the regulation of cell metabolism, but also in cell growth, division, and apoptosis. The active form T3 acts through its nuclear receptors and influences the up- and down-regulation of target genes. Healthy liver tissue expresses a high level of D1, but disturbed D1 activity may result in changes in the local concentration of T3 which may impair gene transcription. These finding demonstrate a low enzymatic activity of D1 in liver hemangioma and suggest an as yet unknown role of thyroid hormones in this type of benign liver tumor
Neuroactivational and Behavioral Correlates of Psychosocial Stress-Induced Cocaine Seeking in Rats
A prominent feature of cocaine abuse is a high risk of relapse even despite prolonged periods of abstinence. Psychosocial stress is thought to be a major contributor to the onset of cocaine craving and relapse in human substance abusers, yet most preclinical models of stress-induced relapse employ physical stressors (e.g., unpredictable footshock) or pharmacological stressors (e.g., yohimbine to elicit a drug seeking response) and do not rely upon psychosocial stress per se. Importantly, social stressors are well known to activate distinct neural circuits within the brain as compared to other stressors. It is therefore possible that currently available animal models of stress-induced drug relapse do not fully engage the neuroanatomical, neurochemical, and/or molecular substrates that are recruited specifically by psychosocial stressors to produce drug-seeking behavior.
Social defeat stress has been proposed as an ethologically valid psychosocial stressor in rodents that more closely models the forms of psychosocial stress that precede relapse episodes in drug abusers. We previously developed a model of psychosocial stress-induced reinstatement in rats in which cocaine seeking is elicited via exposure to a cue signaling impending social defeat stress. Using this model, we discovered that predilection towards displaying active coping behaviors during prior social defeat stress exposures was positively correlated with levels of psychosocial stress-induced cocaine seeking. The present study aimed to expand upon these initial findings by assessing and comparing patterns of neural activation in key brain areas during stress induced cocaine seeking that is triggered by psychosocial or footshock stress predictive cues
The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins.
Nucleoplasmin is a histone chaperone that consists of a pentameric N-terminal domain and an unstructured C-terminal tail. The pentameric core domain, a doughnut-like structure with a central pore, is only found in the nucleoplasmin family. Here, we report the first structure of a nucleoplasmin-like domain (NPL) from the unrelated Drosophila protein, FKBP39, and we present evidence that this protein associates with chromatin. Furthermore, we show that two other chromatin proteins, Arabidopsis thaliana histone deacetylase type 2 (HD2) and Saccharomyces cerevisiae Fpr4, share the NPL fold and form pentamers, or a dimer of pentamers in the case of HD2. Thus, we propose a new family of proteins that share the pentameric nucleoplasmin-like NPL domain and are found in protists, fungi, plants and animals.We are grateful to Gunter Stier for providing the vector; Michael Nilges, Oleg Fedorov, Benjamin Bardiaux, Stefanie Hartmann and Wolfgang Rieping for helpful discussions; and Daniel Nietlispach for NMR expertise. We thank Renato Paro for generously providing us with an anti-FKBP39 antibody. We would like to thank the Wellcome Trust for financial support (grant 082010/Z/07/Z). V.T.F. and E.D.L. acknowledge support from Engineering and Physical Sciences Research Council under grants GR/R99393/01 and EP/C015452/1 for the creation of the Deuteration Laboratory platform operating within the Grenoble Partnership for Structural Biology. V.T.F. also acknowledges support from the European Union under contract RII3-CT-2003-505925. J.B.A. acknowledges the provision of a postdoctoral fellowship held at Keele University. M.R.P. and D.M.G. were supported by the Medical Research Council and Cancer Research UK grants to D.M.G. A.A.W. is a recipient of a Wellcome Trust Fellowship092441/Z/10/Z. J.D. and M.D. were supported by the Harmonia 5 Grant 2013/10/M/NZ2/00298 from the Polish National Science Center. The authors would like to thank the Institut Laue-Langevin (ILL), the European Synchrotron Radiation Facility (ESRF) and the European Molecular Biology Laboratory Hamburg outstation (EMBL-HH) for the provision of beamtime and access to the experimental facilities of D22, ID14eh3 and X33 respectively. We would also like to thank the local contacts at all the facilities for providing assistance in using the beam lines.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.jmb.2015.03.01
The quest for companions to post-common envelope binaries. II. NSVS14256825 and HS0705+6700
We report new mid-eclipse times of the two close binaries NSVS14256825 and
HS0705+6700, harboring an sdB primary and a low-mass main-sequence secondary.
Both objects display clear variations in the measured orbital period, which can
be explained by the action of a third object orbiting the binary. If this
interpretation is correct, the third object in NSVS14256825 is a giant planet
with a mass of roughly 12 M_Jup. For HS0705+6700, we provide evidence that
strengthens the case for the suggested periodic nature of the eclipse time
variation and reduces the uncertainties in the parameters of the brown dwarf
implied by that model. The derived period is 8.4 yr and the mass is 31 M_Jup,
if the orbit is coplanar with the binary. This research is part of the
PlanetFinders project, an ongoing collaboration between professional
astronomers and student groups at high schools.Comment: Accepted by Astron. and Astrophy
The Pentameric Nucleoplasmin Fold Is Present in Drosophila FKBP39 and a Large Number of Chromatin-Related Proteins
Nucleoplasmin is a histone chaperone that consists of a pentameric N-terminal domain and an unstructured C-terminal tail. The pentameric core domain, a doughnut-like structure with a central pore, is only found in the nucleoplasmin family. Here, we report the first structure of a nucleoplasmin-like domain (NPL) from the unrelated Drosophila protein, FKBP39, and we present evidence that this protein associates with chromatin. Furthermore, we show that two other chromatin proteins, Arabidopsis thaliana histone deacetylase type 2 (HD2) and Saccharomyces cerevisiae Fpr4, share the NPL fold and form pentamers, or a dimer of pentamers in the case of HD2. Thus, we propose a new family of proteins that share the pentameric nucleoplasmin-like NPL domain and are found in protists, fungi, plants and animals
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