8 research outputs found
Mémoire sur le Soudan, géographie naturelle et politique, histoire et ethnographie, moeurs et institutions de l'Empire des Fellatas, du Bornou, du Baguermi, du Waday, du Dar-Four, rédigé, d'aprÚs des renseignements entiÚrement nouveaux et accompagné d'une esquisse du Soudan oriental, par M. le Cte d'Escayrac de Lauture,...
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Mémoire sur le ragle ou Hallucination du désert : adressé à l'Académie des sciences / par M. le Cte d'Escayrac de Lauture,.... [suivi du Rapport sur un mémoire de M. le comte d'Escayrac de Lauture relatif au ragle...] / Académie des sciences ; [par Duméril, rapporteur]
Comprend : Rapport sur un mémoire de M. le comte d'Escayrac de Lauture relatif au ragle...Avec mode text
Effect of betamethasone on airway obstruction and bronchial response to salbutamol in prednisolone resistant asthma.
C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia.
While transcription factor C/AAT-enhancer binding protein a (C/EBPa) is critical for normal and leukemic differentiation, its role on cell and metabolic homeostasis is largely unknown in cancer. Here, multi-omics analyses uncovered a coordinated activation of C/EBPa and Fms-like tyrosine kinase 3 (FLT3) that increased lipid anabolism in vivo and in patients with FLT3-mutant acute myeloid leukemia (AML). Mechanistically, C/EBPa regulated FASN-SCD axis to promote fatty acid (FA) biosynthesis and desaturation. We further demonstrated that FLT3 or C/EBPa inactivation decreased mono-unsaturated FA incorporation to membrane phospholipids through SCD downregulation. Consequently, SCD inhibition enhanced susceptibility to lipid redox stress that was exploited by combining FLT3 and glutathione peroxidase 4 inhibition to trigger lipid oxidative stress, enhancing ferroptotic death of FLT3-mutant AML cells. Altogether, our study reveals a C/EBPa function in lipid homeostasis and adaptation to redox stress, and a previously unreported vulnerability of FLT3-mutant AML to ferroptosis with promising therapeutic application