2,213 research outputs found
Clinical Pathology Review
An analysis of the blood from a 5 year old, female Holstein cow as a review of clinical pathology and diagnosis
Naturally-phasematched second harmonic generation in a whispering gallery mode resonator
We demonstrate for the first time natural phase matching for optical
frequency doubling in a high-Q whispering gallery mode resonator made of
Lithium Niobate. A conversion efficiency of 9% is achieved at 30 micro Watt
in-coupled continuous wave pump power. The observed saturation pump power of
3.2 mW is almost two orders of magnitude lower than the state-of-the-art. This
suggests an application of our frequency doubler as a source of non-classical
light requiring only a low-power pump, which easily can be quantum noise
limited. Our theoretical analysis of the three-wave mixing in a whispering
gallery mode resonator provides the relative conversion efficiencies for
frequency doubling in various modes
Compilation and Equivalence of Imperative Objects (Revised Report)
We adopt the untyped imperative object calculus of Abadi andCardelli as a minimal setting in which to study problems of compilationand program equivalence that arise when compiling object orientedlanguages. We present both a big-step and a small-stepsubstitution-based operational semantics for the calculus. Our firsttwo results are theorems asserting the equivalence of our substitution based semantics with a closure-based semantics like that given by Abadi and Cardelli. Our third result is a direct proof of the correctness of compilation to a stack-based abstract machine via a small-step decompilation algorithm. Our fourth result is that contextual equivalence of objects coincides with a form of Mason and Talcott's CIUequivalence; the latter provides a tractable means of establishing operational equivalences. Finally, we prove correct an algorithm, used inour prototype compiler, for statically resolving method offsets. This isthe first study of correctness of an object-oriented abstract machine,and of operational equivalence for the imperative object calculus
Problem-Oriented Approach in Interpreting Clinical Pathology Laboratory Data
We have found that a problem-oriented approach is a valuable method of evaluating laboratory data. Such an approach minimizes the amount of significant data which is overlooked and maximizes the amount of useful information which can be derived from such data. This method also lends itself to incorporation into the problem-oriented record-keeping system
Analysis of optical properties of strained semiconductor quantum dots for electromagnetically induced transparency
Using multiband k*p theory we study the size and geometry dependence on the
slow light properties of conical semiconductor quantum dots. We find the V-type
scheme for electromagnetically induced transparency (EIT) to be most favorable,
and identify an optimal height and size for efficient EIT operation. In case of
the ladder scheme, the existence of additional dipole allowed intraband
transitions along with an almost equidistant energy level spacing adds
additional decay pathways, which significantly impairs the EIT effect. We
further study the influence of strain and band mixing comparing four different
k*p band structure models. In addition to the separation of the heavy and light
holes due to the biaxial strain component, we observe a general reduction in
the transition strengths due to energy crossings in the valence bands caused by
strain and band mixing effects. We furthermore find a non-trivial quantum dot
size dependence of the dipole moments directly related to the biaxial strain
component. Due to the separation of the heavy and light holes the optical
transition strengths between the lower conduction and upper most valence-band
states computed using one-band model and eight-band model show general
qualitative agreement, with exceptions relevant for EIT operation.Comment: 9 pages, 12 figure
A highly efficient two level diamond based single photon source
An unexplored diamond defect centre which is found to emit stable single
photons at a measured rate of 1.6 MHz at room temperature is reported. The
novel centre, identified in chemical vapour deposition grown diamond crystals,
exhibits a sharp zero phonon line at 734 nm with a full width at half maximum
of ~ 4 nm. The photon statistics confirm the center is a single emitter and
provides direct evidence of the first true two-level single quantum system in
diamond.Comment: 3 pages, 4 figure
Larotrectinib efficacy and safety in TRK fusion cancer: An expanded clinical dataset showing consistency in an age and tumor agnostic approach
Background: TRK fusion cancer results from gene fusions involving NTRK1, NTRK2 or NTRK3. Larotrectinib, the first selective TRK inhibitor, has demonstrated an overall response rate (ORR) of 75% with a favorable safety profile in the first 55 consecutively enrolled adult and pediatric patients with TRK fusion cancer (Drilon et al.,NEJM2018). Here, we report the clinical activity of larotrectinib in an additional 35 TRK fusion cancer patients and provide updated follow-up of the primary analysis set (PAS) of 55 patients as of 19thFeb 2018. Methods: Patients with TRK fusion cancer detected by molecular profiling from 3 larotrectinib clinical trials (NCT02122913, NCT02637687, and NCT02576431) were eligible.Larotrectinib was administered until disease progression, withdrawal, or unacceptable toxicity. Disease status was assessed using RECIST version 1.1. Results: As of Feb 2018, by independent review, 6 PRs in the PAS deepened to CRs. The median duration of response (DoR) and progression-free survival in the PAS had still not been reached, with 12.9 months median follow-up. At 1 year, 69% of responses were ongoing, 58% of patients remained progression-free and 90% of patients were alive. An additional 19 children and 25 adults (age range, 0.1-78 years) with TRK fusion cancer were enrolled after the PAS, and included cancers of the salivary gland, thyroid, lung, colon, melanoma, sarcoma, GIST and congenital mesoblastic nephroma. In 35 evaluable patients, the ORR by investigator assessment was 74% (5 CR, 21 PR, 6 SD, 2 PD, 1 not determined). In these patients, with median follow-up of 5.5 months, median DoR had not yet been reached, and 88% of responses were ongoing at 6 months, consistent with the PAS. Adverse events (AEs) were predominantly grade 1, with dizziness, increased AST/ALT, fatigue, nausea and constipation the most common AEs reported in ≥ 10% of patients. No AE of grade 3 or 4 related to larotrectinib occurred in more than 5% of patients. Conclusions: TRK fusions are detected in a broad range of tumor types. Larotrectinib is an effective age- and tumor-agnostic treatment for TRK fusion cancer with a positive safety profile. Screening patients for NTRK gene fusions in solid- and brain tumors should be actively considered
Continuous variable entanglement distillation of Non-Gaussian Mixed States
Many different quantum information communication protocols such as
teleportation, dense coding and entanglement based quantum key distribution are
based on the faithful transmission of entanglement between distant location in
an optical network. The distribution of entanglement in such a network is
however hampered by loss and noise that is inherent in all practical quantum
channels. Thus, to enable faithful transmission one must resort to the protocol
of entanglement distillation. In this paper we present a detailed theoretical
analysis and an experimental realization of continuous variable entanglement
distillation in a channel that is inflicted by different kinds of non-Gaussian
noise. The continuous variable entangled states are generated by exploiting the
third order non-linearity in optical fibers, and the states are sent through a
free-space laboratory channel in which the losses are altered to simulate a
free-space atmospheric channel with varying losses. We use linear optical
components, homodyne measurements and classical communication to distill the
entanglement, and we find that by using this method the entanglement can be
probabilistically increased for some specific non-Gaussian noise channels
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