Diagnosis of Laboratories of Physics and Chemistry in the Universidad Tecnica De Manabi

The following work tries to diagnose the capacities in function of the management of the maintenance of the infrastructure of the laboratories of Physics and Chemistry of the Technical University of Manabí, having as reference the external and internal relations of the processes of maintenance, for the fulfillment Of this purpose a strategic diagnosis of the Universidad Técnica de Manabí (UTM) and the identification of the critical relations of the activities of maintenance of the laboratories of Physics and Chemistry of the UTM and its evaluation of the level of integration is realized

Preface

These proceedings contain the papers of the Third International Workshop on Recent Trends in News Informa-tion Retrieval (NewsIR\u201919) held in conjunction with the ACM SIGIR 2019 conference in Paris, France, on the25thof July 2019. Ten full papers and two short papers (one position paper and one demo paper) were selectedby the programme committee from a total of 21 submissions. Each submitted paper was reviewed by at leastthree members of an international programme committee. In addition to the selected papers, the workshopfeatures one keynote and one invited talk. The Keynote speech is given by Aron Pilhofer \u201cFrom Redlining toRobots: How newsrooms apply technology to the craft of journalism\u201d. The invited talk is given by FriedrichLindenberg \u201cMining Leaks and Open Data to Follow the Money\u201d. We would like to thank SIGIR for hostingus. Thanks also go to the keynote speakers, the program committee, the paper authors, and the participants,for without these people there would be no worksho

QGIS AND OPEN DATA CUBE APPLICATIONS FOR LOCAL CLIMATE ZONES ANALYSIS LEVERAGING PRISMA HYPERSPECTRAL SATELLITE DATA

Climate change poses a significant threat to humans and biodiversity, impacting various aspects of livelihoods, infrastructure, and ecosystems. Understanding climate change and its interaction with the environment is crucial for achieving Sustainable Development Goals. Local Climate Zones (LCZ) play a key role in comprehending climate change by categorizing urban areas also based on their thermal characteristics. This study presents prototype open-source software tools developed to integrate ground and satellite data for LCZ analysis in the Metropolitan City of Milan (Northern Italy). These tools consist of a QGIS plugin to access and preprocess ground-based meteorological sensor data and a client-server platform, based on the Open Data Cube and Docker technologies, for the exploitation of multispectral and hyperspectral satellite data in LCZ mapping and analysis. The tools’ architecture, data retrieval methods, and analysis capabilities are described in detail. The QGIS plugin facilitates the access and preprocessing of ground-based sensor data within the user-friendly QGIS environment. The platform enables seamless ground-sensor and satellite data management and analysis, using Jupyter Notebooks as an interface to support programmatic operations on the data. The proposed tools provide a framework for studying climate change and its local impacts on urban environments, with the potential of empowering users to effectively analyze and mitigate its effects

Sensitive screening of single nucleotide polymorphisms in cell free DNA for diagnosis of gestational tumours

Tumours expressing human chorionic gonadotropin (hCG), the majority of which are difficult to biopsy due to their vascularity, have disparate prognoses depending on their origin. As optimal management relies on accurate diagnosis, we aimed to develop a sensitive cell free DNA (cfDNA) assay to non-invasively distinguish between cases of gestational and non-gestational origin. Deep error-corrected Illumina sequencing of 195 common single nucleotide polymorphisms (SNPs) in cfDNA and matched genomic DNA from 36 patients with hCG-secreting tumours (serum hCG 5 to 3,042,881 IU/L) and 7 controls with normal hCG levels (≤ 4 IU/L) was performed. cfDNA from confirmed gestational tumours with hCG levels ranging from 1,497 to 700,855 IU/L had multiple (n ≥12) ‘non-host’ alleles (i.e. alleles of paternal origin). In such cases the non-host fraction of cfDNA ranged from 0.3% - 40.4% and correlated with serum hCG levels. At lower hCG levels the ability to detect non-host cfDNA was variable, with the detection limit dependent on the type of causative pregnancy. Patients with non-gestational tumours were identifiable by the absence of non-host cfDNA, with copy number alterations detectable in the majority of cases. Following validation in a larger cohort, our sensitive assay will enable clinicians to better inform patients, for whom biopsy is inappropriate, of their prognosis and provide optimum management

Green Buildings and Health

Green building design is becoming broadly adopted, with one green building standard reporting over 3.5 billion square feet certified to date. By definition, green buildings focus on minimizing impacts to the environment through reductions in energy usage, water usage, and minimizing environmental disturbances from the building site. Also by definition, but perhaps less widely recognized, green buildings aim to improve human health through design of healthy indoor environments. The benefits related to reduced energy and water consumption are well-documented, but the potential human health benefits of green buildings are only recently being investigated. The objective of our review was to examine the state of evidence on green building design as it specifically relates to indoor environmental quality and human health. Overall, the initial scientific evidence indicates better indoor environmental quality in green buildings versus non-green buildings, with direct benefits to human health for occupants of those buildings. A limitation of much of the research to date is the reliance on indirect, lagging and subjective measures of health. To address this, we propose a framework for identifying direct, objective and leading “Health Performance Indicators” for use in future studies of buildings and health

DNA methylation and nucleosome occupancy regulate the cancer germline antigen gene MAGEA11

MAGEA11 is a cancer germline (CG) antigen and androgen receptor co-activator. Its expression in cancers other than prostate, and its mechanism of activation, has not been reported. In silico analyses reveal that MAGEA11 is frequently expressed in human cancers, is increased during tumor progression, and correlates with poor prognosis and survival. In prostate and epithelial ovarian cancers (EOC), MAGEA11 expression was associated with promoter and global DNA hypomethylation, and with activation of other CG genes. Pharmacological or genetic inhibition of DNA methyltransferases (DNMTs) and/or histone deacetylases (HDACs) activated MAGEA11 in a cell line specific manner. MAGEA11 promoter activity was directly repressed by DNA methylation, and partially depended on Sp1, as pharmacological or genetic targeting of Sp1 reduced MAGEA11 promoter activity and endogenous gene expression. Importantly, DNA methylation regulated nucleosome occupancy specifically at the -1 positioned nucleosome of MAGEA11. Methylation of a single Ets site near the transcriptional start site (TSS) correlated with -1 nucleosome occupancy and, by itself, strongly repressed MAGEA11 promoter activity. Thus, DNA methylation regulates nucleosome occupancy at MAGEA11, and this appears to function cooperatively with sequence-specific transcription factors to regulate gene expression. MAGEA11 regulation is highly instructive for understanding mechanisms regulating CG antigen genes in human cancer

A highly-resolved food web for insect seed predators in a species-rich tropical forest

The top-down and indirect effects of insects on plant communities depend on patterns of host use, which are often poorly documented, particularly in species-rich tropical forests. At Barro Colorado Island, Panama, we compiled the first food web quantifying trophic interactions between the majority of co-occurring woody plant species and their internally-feeding insect seed predators. Our study is based on more than 200,000 fruits representing 478 plant species, associated with 369 insect species. Insect host-specificity was remarkably high: only 20% of seed predator species were associated with more than one plant species, while each tree species experienced seed predation from a median of two insect species. Phylogeny, but not plant traits, explained patterns of seed predator attack. These data suggest that seed predators are unlikely to mediate indirect interactions such as apparent competition between plant species, but are consistent with their proposed contribution to maintaining plant diversity via the Janzen-Connell mechanism

First measurement of neutrino oscillation parameters using neutrinos and antineutrinos by NOvA.

The NOvA experiment has seen a 4.4σ signal of ν[over ¯]_{e} appearance in a 2 GeV ν[over ¯]_{μ} beam at a distance of 810 km. Using 12.33×10^{20} protons on target delivered to the Fermilab NuMI neutrino beamline, the experiment recorded 27 ν[over ¯]_{μ}→ν[over ¯]_{e} candidates with a background of 10.3 and 102 ν[over ¯]_{μ}→ν[over ¯]_{μ} candidates. This new antineutrino data are combined with neutrino data to measure the parameters |Δm_{32}^{2}|=2.48_{-0.06}^{+0.11}×10^{-3}  eV^{2}/c^{4} and sin^{2}θ_{23} in the ranges from (0.53-0.60) and (0.45-0.48) in the normal neutrino mass hierarchy. The data exclude most values near δ_{CP}=π/2 for the inverted mass hierarchy by more than 3σ and favor the normal neutrino mass hierarchy by 1.9σ and θ_{23} values in the upper octant by 1.6σ