Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

[This corrects the article DOI: 10.1038/s42003-018-0226-0.]

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains. In total, we identify 67 candidate hearing loss genes. We detect known hearing loss genes, but the vast majority, 52, of the candidate genes were novel. Our analysis reveals a large and unexplored genetic landscape involved with auditory function

Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Despite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to the limited access and prohibitive cost of human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report the ophthalmic findings from the International Mouse Phenotyping Consortium, a large-scale functional genetic screen with the goal of generating and phenotyping a null mutant for every mouse gene. Of 4364 genes evaluated, 347 were identified to influence ocular phenotypes, 75% of which are entirely novel in ocular pathology. This discovery greatly increases the current number of genes known to contribute to ophthalmic disease, and it is likely that many of the genes will subsequently prove to be important in human ocular development and disease

Identification of genes required for eye development by high-throughput screening of mouse knockouts

International audienc

Amelioration of right spatial neglect after visuo-motor adaptation to leftward-shifting prisms☆

Visuo-motor adaptation to rightward prismatic shifts reduces signs of left spatial neglect on a wide range of measures(Rossetti et al., 1998; Tilikete et al., 2001; McIntosh et al., 2002; Pisella et al., 2002; Berberovic et al., 2004). As there are hemispheric asymmetries in spatial attention mechanisms, it maybe useful to examine whether prism adaptation can produce similar improvements in neglect of the right hemispace following left hemisphere damage. We report improvement ina patient with mild right spatial neglect following adaptation to leftward-shifting prisms

The Charité Grid Portal: User-friendly and secure access to Grid-based resources and services

The Charit, Grid Portal combines portal components from different groups and projects to provide domain researchers a gateway to Grid-based biomedical applications. Trusted users can securely access and employ Grid resources and services. In this paper, five portal components are presented: (1) The credential management administrates the user-credentials and authenticates them to the Grid. (2) The brain imaging data analysis (FSL) submits workflows to the Grid as part of Medical Image processing. (3) The integrated web services of Generic Workflow Execution Service (GWES) manage workflows executed by users in the Grid. (4) The data management component provides secure and efficient data management in a Grid environment, and enables high-speed data transports between user and Grid. (5) The lung sound analysis application provides twofold-pseudonymization before data-transferred to the Grid. The implementation as standardized portlets allows easy integration of specific components into different Grid portals such as the VO specific MediGRID and PneumoGrid portals