Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders.

Neuronal glucose transporter (GLUT) isoform 3 deficiency in null heterozygous mice led to abnormal spatial learning and working memory but normal acquisition and retrieval during contextual conditioning, abnormal cognitive flexibility with intact gross motor ability, electroencephalographic seizures, perturbed social behavior with reduced vocalization and stereotypies at low frequency. This phenotypic expression is unique as it combines the neurobehavioral with the epileptiform characteristics of autism spectrum disorders. This clinical presentation occurred despite metabolic adaptations consisting of an increase in microvascular/glial GLUT1, neuronal GLUT8 and monocarboxylate transporter isoform 2 concentrations, with minimal to no change in brain glucose uptake but an increase in lactate uptake. Neuron-specific glucose deficiency has a negative impact on neurodevelopment interfering with functional competence. This is the first description of GLUT3 deficiency that forms a possible novel genetic mechanism for pervasive developmental disorders, such as the neuropsychiatric autism spectrum disorders, requiring further investigation in humans

Curvature-induced spin-orbit coupling and spin relaxation in a chemically clean single-layer graphene

The study of spin-related phenomena in materials requires knowledge on the precise form of effective spin-orbit coupling of conducting carriers in the solid-states systems. We demonstrate theoretically that curvature induced by corrugations or periodic ripples in single-layer graphenes generates two types of effective spin-orbit coupling. In addition to the spin-orbit coupling reported previously that couples with sublattice pseudospin and corresponds to the Rashba-type spin-orbit coupling in a corrugated single-layer graphene, there is an additional spin-orbit coupling that does not couple with the pseudospin, which can not be obtained from the extension of the curvature-induced spin-orbit coupling of carbon nanotubes. Via numerical calculation we show that both types of the curvature-induced spin-orbit coupling make the same order of contribution to spin relaxation in chemically clean single-layer graphene with nanoscale corrugation. The spin relaxation dependence on the corrugation roughness is also studied.Comment: 8 pages, 4 figure

Affleck-Dine Baryogenesis, Split Supersymmetry, and Inflation

It is shown that, in the context of split supersymmetry, a simple model with a single complex scalar field can produce chaotic inflation and generate the observed amount of baryon asymmetry via the Affleck-Dine mechanism. While the inflaton quantum fluctuations give rise to curvature perturbation, we show that quantum fluctuations of the phase of the scalar field can produce baryonic isocurvature perturbation. Combining with constraints from WMAP data, all parameters in the model can be determined to within a narrow range.Comment: version accepted for publication in PR

Black hole formation in bidimensional dilaton gravity coupled to scalar matter systems

This work deals with the formation of black hole in bidimensional dilaton gravity coupled to scalar matter fields. We investigate two scalar matter systems, one described by a sixth power potential and the other defined with two scalar fields containing up to the fourth power in the fields. The topological solutions that appear in these cases allow the formation of black holes in the corresponding dilaton gravity models.Comment: Latex, 9 pages. Published in Mod. Phys. Lett. A14 (1999) 268

Collective patterns arising out of spatio-temporal chaos

We present a simple mathematical model in which a time averaged pattern emerges out of spatio-temporal chaos as a result of the collective action of chaotic fluctuations. Our evolution equation possesses spatial translational symmetry under a periodic boundary condition. Thus the spatial inhomogeneity of the statistical state arises through a spontaneous symmetry breaking. The transition from a state of homogeneous spatio-temporal chaos to one exhibiting spatial order is explained by introducing a collective viscosity which relates the averaged pattern with a correlation of the fluctuations.Comment: 11 pages (Revtex) + 5 figures (postscript

Optical Weak Link between Two Spatially Separate Bose-Einstein Condensates

Two spatially separate Bose-Einstein condensates were prepared in an optical double-well potential. A bidirectional coupling between the two condensates was established by two pairs of Bragg beams which continuously outcoupled atoms in opposite directions. The atomic currents induced by the optical coupling depend on the relative phase of the two condensates and on an additional controllable coupling phase. This was observed through symmetric and antisymmetric correlations between the two outcoupled atom fluxes. A Josephson optical coupling of two condensates in a ring geometry is proposed. The continuous outcoupling method was used to monitor slow relative motions of two elongated condensates and characterize the trapping potential.Comment: 4 pages, 5 figure

Y-System and Deformed Thermodynamic Bethe Ansatz

We introduce a new tool, the Deformed TBA (Deformed Thermodynamic Bethe Ansatz), to analyze the monodromy problem of the cubic oscillator. The Deformed TBA is a system of five coupled nonlinear integral equations, which in a particular case reduces to the Zamolodchikov TBA equation for the 3-state Potts model. Our method generalizes the Dorey-Tateo analysis of the (monomial) cubic oscillator. We introduce a Y-system corresponding to the Deformed TBA and give it an elegant geometric interpretation.Comment: 12 pages. Minor corrections in Section

Attitude Control for an Aero-Vehicle Using Vector Thrusting and Variable Speed Control Moment Gyros

Stabilization of passively unstable thrust-levitated vehicles can require significant control inputs. Although thrust vectoring is a straightforward choice for realizing these inputs, this may lead to difficulties discussed in the paper. This paper examines supplementing thrust vectoring with Variable-Speed Control Moment Gyroscopes (VSCMGs). The paper describes how to allocate VSCMGs and the vectored thrust mechanism for attitude stabilization in frequency domain and also shows trade-off between vectored thrust and VSCMGs. Using an H2 control synthesis methodology in LMI optimization, a feedback control law is designed for a thrust-levitated research vehicle and is simulated with the full nonlinear model. It is demonstrated that VSCMGs can reduce the use of vectored thrust variation for stabilizing the hovering platform in the presence of strong wind gusts

First-principles study on the intermediate compounds of LiBH4_4

We report the results of the first-principles calculation on the intermediate compounds of LiBH$_4$. The stability of LiB$_3$H$_8$ and Li$_2$B$_n$H$_n (n=5-12)$ has been examined with the ultrasoft pseudopotential method based on the density functional theory. Theoretical prediction has suggested that monoclinic Li$_2$B$_{12}$H$_{12}$ is the most stable among the candidate materials. We propose the following hydriding/dehydriding process of LiBH$_4$ via this intermediate compound : LiBH$_4 \leftrightarrow {1/12}$Li$_{2}$B$_{12}$H$_{12} + {5/6}$ LiH $+ {13/12}$H$_2 \leftrightarrow$LiH $+$ B $+ {3/2}$H$_2$. The hydrogen content and enthalpy of the first reaction are estimated to be 10 mass% and 56 kJ/mol H$_2$, respectively, and those of the second reaction are 4 mass% and 125 kJ/mol H$_2$. They are in good agreement with experimental results of the thermal desorption spectra of LiBH$_4$. Our calculation has predicted that the bending modes for the $\Gamma$-phonon frequencies of monoclinic Li$_2$B$_{12}$H$_{12}$ are lower than that of LiBH$_4$, while stretching modes are higher. These results are very useful for the experimental search and identification of possible intermediate compounds.Comment: 7 pages, 5 figures, submitted to PR