E-Pharmacing and Online Medical Laborotary System

Pharmacies are not exempt from the changes taking place in the healthcare sector. Web-based application designed to manage tasks in medical laboratories, pharmacies, and the users. It is possible to find the causes and problems of all the illnesses occurring in the customer's body and to perform all the necessary medical tests. Users can get all the details about the available drug counts and inventories using a prescription scanner. There is also an artificial intelligent virtual medical bot providing 24/7 service. Emergency patient can easily learn about the medicine and how to use it and can also know the details needed to contact a nearby hospital. A chat bot is like a virtual human that is used after having a relationship with the user. This study's main goal is to demonstrate how these technologies are employed, as well as their benefits and significance. A new feature introduced here is the creation of a delivery tracking system. This way you can get information about delivery update status from home and can promote a nature friendly environment. A new feature we are introducing here is the creation of a barcode card number by itself. The ccd method is used to create this barcode number

Travel Planner Web Implementation

“Soul Travel” is a travel planning application built for a travel agency which is based in Colombo, Sri Lanka. The agency currently uses a manual process to plan the journey for their customers. The customer has to visit or call the agency to plan or book their journey. The proposed system includes mainly two modules. One module allows customers to manually select their destinations, flights, hotels, and vehicles and come up with their own package while the other module allows customers to book the package with a fixed number of items the agency provides. After that the selected packages will be saved under the user's account and one of threadfins will be able to process the packages that the users have created. In addition to that, the admin users will be able to add destinations, hotels, cars, and flights to the system and manage them accordingly. This system improves the efficiency of the current process while attracting more customers to the agency

Geometrically guided and confidence-based point cloud denoising

The generation of photogrammetric point clouds from satellite images is often based on image correlation techniques. Correlation errors can arise for a wide variety of reasons: transient objects, homogeneous areas, shadows, and surface discontinuities. Therefore, a simple 3D Gaussian distribution at the point cloud level is not an appropriate model. In this paper, we propose a new point cloud denoising method integrated into the Multiview Stereo Pipeline CARS, dedicated to satellite imagery. Building upon bilateral filtering principles, our approach introduces a novel utilization of color information, confidence estimation and geometric constraints alongside point positions and normals. While the use of point color increases the level of detail, the addition of geometric constraints and confidence awareness guides processing towards a realistic solution. We propose an ablation study and compare our solution against a previously established bilateral filter with LiDAR data as ground truth

Mapping Schistosoma haematobium for Novel Interventions against Female Genital Schistosomiasis and Associated HIV Risk in KwaZulu-Natal, South Africa

publishedVersio

Genomic and Epidemiological Analysis of SARS-CoV-2 Viruses in Sri Lanka.

Background: In order to understand the molecular epidemiology of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Sri Lanka, since March 2020, we carried out genomic sequencing overlaid on available epidemiological data until April 2021. Methods: Whole genome sequencing was carried out on diagnostic sputum or nasopharyngeal swabs from 373 patients with COVID-19. Molecular clock phylogenetic analysis was undertaken to further explore dominant lineages. Results: The B.1.411 lineage was most prevalent, which was established in Sri Lanka and caused outbreaks throughout the country until March 2021. The estimated time of the most recent common ancestor (tMRCA) of this lineage was June 1, 2020 (with 95% lower and upper bounds March 30 to July 27) suggesting cryptic transmission may have occurred, prior to a large epidemic starting in October 2020. Returning travellers were identified with infections caused by lineage B.1.258, as well as the more transmissible B.1.1.7 lineage, which has replaced B.1.411 to fuel the ongoing large outbreak in the country. Conclusions: The large outbreak that started in early October, is due to spread of a single virus lineage, B.1.411 until the end of March 2021, when B.1.1.7 emerged and became the dominant lineage

Expression of a Constitutively Active Calcineurin Encoded by an Intron-Retaining mRNA in Follicular Keratinocytes

Hair growth is a highly regulated cyclical process. Immunosuppressive immunophilin ligands such as cyclosporin A (CsA) and FK506 are known as potent hair growth modulatory agents in rodents and humans that induce active hair growth and inhibit hair follicle regression. The immunosuppressive effectiveness of these drugs has been generally attributed to inhibition of T cell activation through well-characterized pathways. Specifically, CsA and FK506 bind to intracellular proteins, principally cyclophilin A and FKBP12, respectively, and thereby inhibit the phosphatase calcineurin (Cn). The calcineurin (Cn)/NFAT pathway has an important, but poorly understood, role in the regulation of hair follicle development. Here we show that a novel-splicing variant of calcineurin Aß CnAß-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes but not in the proliferating keratinocytes of rodents. CnAß-FK was weakly sensitive to Ca2+ and dephosphorylated NFATc2 under low Ca2+ levels in keratinocytes. Inhibition of Cn/NFAT induced hair growth in nude mice. Cyclin G2 was identified as a novel target of the Cn/NFATc2 pathway and its expression in follicular keratinocytes was reduced by inhibition of Cn/NFAT. Overexpression of cyclin G2 arrested the cell cycle in follicular keratinocytes in vitro and the Cn inhibitor, cyclosporin A, inhibited nuclear localization of NFATc2, resulting in decreased cyclin G2 expression in follicular keratinocytes of rats in vivo. We therefore suggest that the calcineurin/NFAT pathway has a unique regulatory role in hair follicle development

Genomic and epidemiological analysis of SARS-CoV-2 viruses in Sri Lanka

Background: In order to understand the molecular epidemiology of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Sri Lanka, since March 2020, we carried out genomic sequencing overlaid on available epidemiological data until April 2021. Methods: Whole genome sequencing was carried out on diagnostic sputum or nasopharyngeal swabs from 373 patients with COVID-19. Molecular clock phylogenetic analysis was undertaken to further explore dominant lineages. Results: The B.1.411 lineage was most prevalent, which was established in Sri Lanka and caused outbreaks throughout the country until March 2021. The estimated time of the most recent common ancestor (tMRCA) of this lineage was June 1, 2020 (with 95% lower and upper bounds March 30 to July 27) suggesting cryptic transmission may have occurred, prior to a large epidemic starting in October 2020. Returning travellers were identified with infections caused by lineage B.1.258, as well as the more transmissible B.1.1.7 lineage, which has replaced B.1.411 to fuel the ongoing large outbreak in the country. Conclusions: The large outbreak that started in early October, is due to spread of a single virus lineage, B.1.411 until the end of March 2021, when B.1.1.7 emerged and became the dominant lineage