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Building thermal performance, extreme heat, and climate change
The leading source of weather-related deaths in the United States is heat, and future projections show that the frequency, duration, and intensity of heat events will increase in the Southwest. Presently, there is a dearth of knowledge about how infrastructure may perform during heat waves or could contribute to social vulnerability. To understand how buildings perform in heat and potentially stress people, indoor air temperature changes when air conditioning is inaccessible are modeled for building archetypes in Los Angeles, California, and Phoenix, Arizona, when air conditioning is inaccessible is estimated. An energy simulation model is used to estimate how quickly indoor air temperature changes when building archetypes are exposed to extreme heat. Building age and geometry (which together determine the building envelope material composition) are found to be the strongest indicators of thermal envelope performance. Older neighborhoods in Los Angeles and Phoenix (often more centrally located in the metropolitan areas) are found to contain the buildings whose interiors warm the fastest, raising particular concern because these regions are also forecast to experience temperature increases. To combat infrastructure vulnerability and provide heat refuge for residents, incentives should be adopted to strategically retrofit buildings where both socially vulnerable populations reside and increasing temperatures are forecast
Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little information exists with respect to the alpha V subfamily. In the present study we show that alpha V can associate with multiple and different beta subunits capable of binding fibronectin in this tumour type. This is likely to have functional implications for growth and spread of colorectal cancer
Strong inapproximability of the shortest reset word
The \v{C}ern\'y conjecture states that every -state synchronizing
automaton has a reset word of length at most . We study the hardness
of finding short reset words. It is known that the exact version of the
problem, i.e., finding the shortest reset word, is NP-hard and coNP-hard, and
complete for the DP class, and that approximating the length of the shortest
reset word within a factor of is NP-hard [Gerbush and Heeringa,
CIAA'10], even for the binary alphabet [Berlinkov, DLT'13]. We significantly
improve on these results by showing that, for every , it is NP-hard
to approximate the length of the shortest reset word within a factor of
. This is essentially tight since a simple -approximation
algorithm exists.Comment: extended abstract to appear in MFCS 201
Synchronization Problems in Automata without Non-trivial Cycles
We study the computational complexity of various problems related to
synchronization of weakly acyclic automata, a subclass of widely studied
aperiodic automata. We provide upper and lower bounds on the length of a
shortest word synchronizing a weakly acyclic automaton or, more generally, a
subset of its states, and show that the problem of approximating this length is
hard. We investigate the complexity of finding a synchronizing set of states of
maximum size. We also show inapproximability of the problem of computing the
rank of a subset of states in a binary weakly acyclic automaton and prove that
several problems related to recognizing a synchronizing subset of states in
such automata are NP-complete.Comment: Extended and corrected version, including arXiv:1608.00889.
Conference version was published at CIAA 2017, LNCS vol. 10329, pages
188-200, 201
Non-invasive detection of animal nerve impulses with an atomic magnetometer operating near quantum limited sensitivity
Magnetic fields generated by human and animal organs, such as the heart,
brain and nervous system carry information useful for biological and medical
purposes. These magnetic fields are most commonly detected using
cryogenically-cooled superconducting magnetometers. Here we present the frst
detection of action potentials from an animal nerve using an optical atomic
magnetometer. Using an optimal design we are able to achieve the sensitivity
dominated by the quantum shot noise of light and quantum projection noise of
atomic spins. Such sensitivity allows us to measure the nerve impulse with a
miniature room-temperature sensor which is a critical advantage for biomedical
applications. Positioning the sensor at a distance of a few millimeters from
the nerve, corresponding to the distance between the skin and nerves in
biological studies, we detect the magnetic field generated by an action
potential of a frog sciatic nerve. From the magnetic field measurements we
determine the activity of the nerve and the temporal shape of the nerve
impulse. This work opens new ways towards implementing optical magnetometers as
practical devices for medical diagnostics.Comment: Main text with figures, and methods and supplementary informatio
Borel-Moore motivic homology and weight structure on mixed motives
By defining and studying functorial properties of the Borel-Moore motivic
homology, we identify the heart of Bondarko-H\'ebert's weight structure on
Beilinson motives with Corti-Hanamura's category of Chow motives over a base,
therefore answering a question of Bondarko
The gradient of potential vorticity, quaternions and an orthonormal frame for fluid particles
The gradient of potential vorticity (PV) is an important quantity because of
the way PV (denoted as ) tends to accumulate locally in the oceans and
atmospheres. Recent analysis by the authors has shown that the vector quantity
\bdB = \bnabla q\times \bnabla\theta for the three-dimensional incompressible
rotating Euler equations evolves according to the same stretching equation as
for \bom the vorticity and \bB, the magnetic field in magnetohydrodynamics
(MHD). The \bdB-vector therefore acts like the vorticity \bom in Euler's
equations and the \bB-field in MHD. For example, it allows various analogies,
such as stretching dynamics, helicity, superhelicity and cross helicity. In
addition, using quaternionic analysis, the dynamics of the \bdB-vector
naturally allow the construction of an orthonormal frame attached to fluid
particles\,; this is designated as a quaternion frame. The alignment dynamics
of this frame are particularly relevant to the three-axis rotations that
particles undergo as they traverse regions of a flow when the PV gradient
\bnabla q is large.Comment: Dedicated to Raymond Hide on the occasion of his 80th birthda
Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment?
To sustain their malignancy, tumour cells acquire several metabolic adaptations such as increased oxygen, glucose, glutamine, and lipids uptake. Other metabolic processes are also enhanced as part of tumour metabolic reprogramming, for example, increased serine metabolism. Serine is a non-essential amino acid that supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, DNA, and glutathione synthesis. Indeed, increased activity of D-3-phosphoglycerate dehydrogenase (PHGDH), the enzyme rate-limiting de novo serine synthesis, has been extensively reported in several tumours. Therefore, selective inhibition of PHGDH may represent a new therapeutic strategy for over-expressing PHGDH tumours, owing to its downstream inhibition of essential biomass production such as one-carbon units and nucleotides. This perspective article will discuss the current status of research into small molecular inhibitors against PHGDH in colorectal cancer, breast cancer, and Ewing's sarcoma. We will summarise recent studies on the development of PHGDH-inhibitors, highlighting their clinical potential as new therapeutics. It also wants to shed a light on some of the key limitations of the use of PHGDH-inhibitors in cancer treatment which are worth taking into account
Combinatorics of -orbits and Bruhat--Chevalley order on involutions
Let be the group of invertible upper-triangular complex
matrices, the space of upper-triangular complex matrices with
zeroes on the diagonal and its dual space. The group acts
on by , , ,
.
To each involution in , the symmetric group on letters, one
can assign the -orbit . We present a
combinatorial description of the partial order on the set of involutions
induced by the orbit closures. The answer is given in terms of rook placements
and is dual to A. Melnikov's results on -orbits on .
Using results of F. Incitti, we also prove that this partial order coincides
with the restriction of the Bruhat--Chevalley order to the set of involutions.Comment: 27 page
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