The narration of the data as underestimation of the oriental victim

El presente artículo parte de la premisa de que la práctica discursiva sobre la muerte oriental, iniciada por las agencias de saber, puede corresponder a una subestimación narrativa de los territorios y de las personas presentes en un espacio polisémico llamado MENA. La hipótesis investigada, a través de la comparación de diferentes fuentes estadísticas secundarias (2001-2017), muestra que la mayoría de las víctimas del terrorismo no se sitúan en el área geográfica occidental, sino en la región de Oriente Medio y África del Norte. Esta interpretación de los datos estadísticos presupone que el número de las muertes, manipuladas en una clave positivista, participa en el proceso más general de “esencialización racial” del espacio. Por lo tanto, lo que nos proponemos hacer es reflexionar sobre la narración de “datos” que alimenta cierta retórica gubernamental de MENA. Metodológicamente, la comparación de diferentes datos aclara que existe una “subestimación geográfica” relacionada con una “sobrenarración” del evento terrorista, descrito como una amenaza oriental. Esta “sobreexposición” tiene el efecto de subestimar a la víctima local, puesto que la inscripción geográfica del MENA, comprendida como un espacio de terror, arrebata la dignidad de la muerte a las poblaciones orientales.In this article, we assume the narrative on oriental deaths initiated by agencies of knowledge, may correspond to an underestimation of those people and territories present in a polysemous space called MENA. Comparing different secondary statistical sources (2001-2017), we can presume that most of the victims of terrorism did not occur in the Western geographical area, but in the Middle East and North African ones. Such interpretation of statistical data assumes that the number of deaths, manipulated in a positivist way, participates in the more general process of “racial profiling” of space. Therefore, in this article we propose to reflect on the narration of the data feeding the MENA government rhetoric, as data clarifies that there is a geographical underestimation due to an over-narration of the more complex terrorist event as an oriental menace. The effect of this overexposure is an underestimation of the local victims, because the geographical inscription of the MENA as a space of terror takes dignity away from the death of the Middle East and North African population

4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis

A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substituents were linked to N1 of the hydrazone in order to establish robust structure–activity relationships. The results of the biological testing demonstrated that the presence of the hydrazothiazole nucleus bearing at C4 a phenyl ring functionalised at the meta position with a nitro group represents an important pharmacophoric feature to obtain selective and reversible human MAO-B inhibition for the treatment of neurodegenerative disorders. In addition, the most potent and selective MAO-B inhibitors were evaluated in silico as potential cholinesterase (AChE/BuChE) inhibitors and in vitro for antioxidant activities. The results obtained from molecular modelling studies provided insight into the multiple interactions and structural requirements for the reported MAO inhibitory properties

Novel insights on HIV/AIDS and cardiac disease:shedding light on the HAART of Darkness

Comment on Acute coronary syndromes in human immunodeficiency virus patients: a meta-analysis investigating adverse event rates and the role of antiretroviral therapy. [Eur Heart J. 2012] Acute coronary syndromes in human immunodeficiency virus patients: a meta-analysis investigating adverse event rates and the role of antiretroviral therapy.D'Ascenzo F, Cerrato E, Biondi-Zoccai G, Moretti C, Omedè P, Sciuto F, Bollati M, Modena MG, Gaita F, Sheiban I. Eur Heart J. 2012 Apr; 33(7):875-80. Epub 2011 Dec 20. Contribution of the human immunodeficiency virus/acquired immunodeficiency syndrome epidemic to de novo presentations of heart disease in the Heart of Soweto Study cohort. [Eur Heart J. 2012

Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors

A series of 4-substituted-2-thiazolylhydrazone derivatives have been synthesized and tested in vitro for their human monoamine oxidase (hMAO) A and B inhibitory activity. Our findings confirmed that the substitution at C4 of the thiazole ring was important to obtain highly potent and selective hMAO-B inhibitors with IC50 values in the nanomolar range. Moreover, these derivatives were endowed with a reversible mechanism of enzyme inhibition. Molecular modelling studies were performed to rationalize the recognition of all inhibitors with respect to hMAO-A and -B isoforms

Exploring (4-substituted-thiazol-2-yl)hydrazine derivatives of 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors.

A series of 4-substituted-2-thiazolylhydrazone derivatives have been synthesized and tested in vitro for their human monoamine oxidase (hMAO) A and B inhibitory activity. Our findings confirmed that the substitution at C4 of the thiazole ring was important to obtain highly potent and selective hMAO-B inhibitors with IC50 values in the nanomolar range. Moreover, these derivatives were endowed with a reversible mechanism of enzyme inhibition. Molecular modelling studies were performed to rationalize the recognition of all inhibitors with respect to hMAO-A and -B isoforms

(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies

Several (thiazol-2-yl)hydrazone derivatives from 2-, 3- and 4-acetylpyridine were synthesized and tested against human monoamine oxidase (hMAO) A and B enzymes. Most of them had an inhibitory effect in the low micromolar/high nanomolar range, being derivatives of 4-acetylpyridine selective hMAO-B inhibitors also at low nanomolar concentrations. The structure-activity relationship, as confirmed by molecular modeling studies, proved that the pyridine ring linked to the hydrazonic nitrogen and the substituted aryl moiety at C4 of the thiazole conferred the inhibitory effects on hMAO enzymes. Successively, the strongest hMAO-B inhibitors were tested toward acetylcholinesterase (AChE) and the most interesting compound showed activity in the low micromolar range. Our results suggest that this scaffold could be further investigated for its potential multi-targeted role in the discovery of new drugs against the neurodegenerative diseases