Social Media and Gender Violence: Communication Strategies for a “New Education”

This study investigates the role of social media in cultural awarenessraising and engagement in the struggle against gender violence. The study was conducted using a quantitative/qualitative analysis approach of around 20 Italian social websites-platforms-pages dealing with the phenomenon of femicide. The analysis considers three main indicators: presence of Web spaces for awarenessraising (e.g. advertising campaigns, contest); the existence of Web channels and participatory tools targeting the achievement of shared objectives and projects (e.g. signatures, online petitions); activation of online educational courses (e.g. information-based pages on the themes and terms of gender-based violence, creation of “pedagogical” and comparative spaces). The study sought to detect the extent to which the opportunities offered by new technologies in terms of social channel use, the viral spread of messages, and even the capacity to create new spaces for shared reflection, actually have an educational/pedagogical purpose rather than a merely awareness-raising or mobilization function

P2Y2 and P2Y6 receptor activation elicits intracellular calcium responses in human adipose-derived mesenchymal stromal cells

Adipose tissue contains self-renewing multipotent cells termed mesenchymal stromal cells. In situ, these cells serve to expand adipose tissue by adipogenesis, but their multipotency has gained interest for use in tissue regeneration. Little is known regarding the repertoire of receptors expressed by adipose-derived mesenchymal stromal cells (AD-MSCs). The purpose of this study was to undertake a comprehensive analysis of purinergic receptor expression. Mesenchymal stromal cells were isolated from human subcutaneous adipose tissue and confirmed by flow cytometry. The expression profile of purinergic receptors was determined by quantitative real-time PCR and immunocytochemistry. The molecular basis for adenine and uracil nucleotide-evoked intracellular calcium responses was determined using Fura-2 measurements. All the known subtypes of P2X and P2Y receptors, excluding P2X2, P2X3 and P2Y12 receptors, were detected at the mRNA and protein level. ATP, ADP and UTP elicited concentration-dependent calcium responses in mesenchymal cells (N = 7–9 donors), with a potency ranking ADP (EC50 1.3 ± 1.0 μM) > ATP (EC50 2.2 ± 1.1 μM) = UTP (3.2 ± 2.8 μM). Cells were unresponsive to UDP (< 30 μM) and UDP-glucose (< 30 μM). ATP responses were attenuated by selective P2Y2 receptor antagonism (AR-C118925XX; IC50 1.1 ± 0.8 μM, 73.0 ± 8.5% max inhibition; N = 7 donors), and UTP responses were abolished. ADP responses were attenuated by the selective P2Y6 receptor antagonist, MRS2587 (IC50 437 ± 133nM, 81.0 ± 8.4% max inhibition; N = 6 donors). These data demonstrate that adenine and uracil nucleotides elicit intracellular calcium responses in human AD-MSCs with a predominant role for P2Y2 and P2Y6 receptor activation. This study furthers understanding about how human adipose-derived mesenchymal stromal cells can respond to external signalling cues

Self-force: Computational Strategies

Building on substantial foundational progress in understanding the effect of a small body's self-field on its own motion, the past 15 years has seen the emergence of several strategies for explicitly computing self-field corrections to the equations of motion of a small, point-like charge. These approaches broadly fall into three categories: (i) mode-sum regularization, (ii) effective source approaches and (iii) worldline convolution methods. This paper reviews the various approaches and gives details of how each one is implemented in practice, highlighting some of the key features in each case.Comment: Synchronized with final published version. Review to appear in "Equations of Motion in Relativistic Gravity", published as part of the Springer "Fundamental Theories of Physics" series. D. Puetzfeld et al. (eds.), Equations of Motion in Relativistic Gravity, Fundamental Theories of Physics 179, Springer, 201

European Sentiment in time of crises. The point of view of young university students

The latest emergencies – economic, refugee, and the pandemic of Covid-19 – has impacted in European collective identity construction, especially in Southern Europe. This article investigates if the pandemic crisis has activated in young Italian and Spanish university students nationalistic or/and European responses. The analysis, based on an online survey, uses the partial least squares structural equation modelling (PLS-SEM) statistical method to perform an exploratory analysis of the explanatory theoretical model of European sentiment. The results show that young people attribute several meanings to Europe during the pandemic, which are based mainly on making informed decisions and recognizing a common space of interaction as an opportunity of peace, security and democracy. The findings highlight the role of EU communicative actions in increasing trust in national and European institutions