Implementation of the control strategy for a 2D nanopositioning long range stage

A 2D-platform stage able to obtain an effective metrological positioning with nanometer resolution and long working range (50 x 50 mm2) is on development at the University of Zaragoza. The 2D stage has already been designed, manufactured and assembled. The movement of the platform is performed by four custom-made linear motors, and mirror laser interferometers work as positioning sensors in XYRz degrees of freedom. The work here presented focuses on the hardware implementation of the motor control, for one actuator on a 1D linear stage. The developed control strategy acts on three-phase PWM (Pulse-Width Modulation) signals and a feedback is provided by measuring the phase currents. As a preliminary solution, a sensorless algorithm substitutes the positioning sensor before implementing the laser interferometers

Geometrical characterisation of a 2D laser system and calibration of a cross-grid encoder by means of a self-calibration methodology

This article presents a self-calibration procedure and the experimental results for the geometrical characterisation of a 2D laser system operating along a large working range (50 mm × 50 mm) with submicrometre uncertainty. Its purpose is to correct the geometric errors of the 2D laser system setup generated when positioning the two laser heads and the plane mirrors used as reflectors. The non-calibrated artefact used in this procedure is a commercial grid encoder that is also a measuring instrument. Therefore, the self-calibration procedure also allows the determination of the geometrical errors of the grid encoder, including its squareness error. The precision of the proposed algorithm is tested using virtual data. Actual measurements are subsequently registered, and the algorithm is applied. Once the laser system is characterised, the error of the grid encoder is calculated along the working range, resulting in an expanded submicrometre calibration uncertainty (k = 2) for the X and Y axes. The results of the grid encoder calibration are comparable to the errors provided by the calibration certificate for its main central axes. It is, therefore, possible to confirm the suitability of the self-calibration methodology proposed in this article

Uncertainty budget of a large-range nanopositioning platform based on Monte Carlo simulation

The objective of precision systems design is to obtain machines with very high and totally predictable work-zone accuracies. In already functional systems, where the errors can be measured, this is achieved by error correction and compensation. The aim of this work is to propose an uncertainty budget methodology to obtain the final measuring uncertainty of precise measuring systems, after error compensation. The case study is a nanopositioning platform, referred as NanoPla, with a confocal sensor integrated as measuring instrument. The NanoPla performs precise positioning in a large range of 50 mm × 50 mm, and its target is surface topography characterization, at a submicrometre scale. After performing the uncertainty budget of the NanoPla, Monte Carlo method is used to obtain the final measuring uncertainty along the whole NanoPla working range, considering all the casuistry. By studying the results, the authors are able to propose solutions to minimize the final measuring uncertainty

Reference standard for the uncertainty estimation of X–ray Computed Tomography measurements of complex macro-and micro-geometries

Traditionally, measuring both macro and micro geometries with a single device has been challenging in metrology. Coordinate Measuring Machines (CMM) are common devices for the inspection of large features, while optical microscopes can achieve resolutions in the order of micrometers in small areas. X-Ray Computed Tomography (XCT) has become a solution not only to characterize both micro and macro geometries, but also to inspect internal features without destroying the sample. In this field, various reference standards have been developed in order to verify the capabilities of XCT systems, these artefacts include geometrical features or profiles for roughness inspection. This paper shows the design and develompent of a reference standard for XCT test which includes internal and external geometrical features and profiles for macro and micro geometrical inspection. The model is manufactured by additive manufacturing (AM), easing the process of fabrication of the artefact and allowing to test the capabilities of this technology to produce reference standards

I Congreso internacional de la SECAH. Ex officina Hispana. Cádiz Mayo 2011

Acta del I Congreso Internacional de la Sociedad de Estudios de Cerámica antigua en Hispani

Taxanes convert regions of perturbed microtubule growth into rescue sites

Microtubules are polymers of tubulin dimers, and conformational transitions in the microtubule lattice drive microtubule dynamic instability and affect various aspects of microtubule function. The exact nature of these transitions and their modulation by anti -cancer drugs such as Taxol and epothilone, which can stabilize microtubules but also perturb their growth, are poorly understood. Here, we directly visualize the action of fluorescent Taxol and epothilone derivatives and show that microtubules can transition to a state that triggers cooperative drug binding to form regions with altered lattice conformation. Such regions emerge at growing microtubule ends that are in a pre-catastrophe state and inhibit microtubule growth and shortening. Electron microscopy and in vitro dynamics data indicate that taxane accumulation zones represent incomplete tubes that can persist, incorporate tubulin dimers and repeatedly induce microtubule rescues. Thus, taxanes modulate the material properties of microtubules by converting destabilized growing microtubule ends into regions resistant to depolymerization

Robust exponential decay of correlations for singular-flows

We construct open sets of Ck (k bigger or equal to 2) vector fields with singularities that have robust exponential decay of correlations with respect to the unique physical measure. In particular we prove that the geometric Lorenz attractor has exponential decay of correlations with respect to the unique physical measure.Comment: Final version accepted for publication with added corrections (not in official published version) after O. Butterley pointed out to the authors that the last estimate in the argument in Subsection 4.2.3 of the previous version is not enough to guarantee the uniform non-integrability condition claimed. We have modified the argument and present it here in the same Subsection. 3 figures, 34 page

Micro-opto-electro-mechanical device based on flexible beta-Ga_2O_3 micro-lamellas

A thermal actuator based on thin flexible lamellas of Ga_2O_3 was designed in order to demonstrate the potential of this semiconductor for micro-opto-electro-mechanical applications (MOEMs). The working principle of these devices is based on the thermal expansion that induces a vertical movement resultant of the lamella elongation due the self-heating/Joule effect. Upon excitation with photons, electrons or ions, intrinsic luminescence bands associated with self-trapped excitons and donor-acceptor pair recombination dominate the emission spectrum. When a current passes through the device, simultaneously with the thermal expansion, this luminescence is strongly quenched. Based on systematic Photoluminescence and Raman studies as a function of temperature and as a function of the applied power it is demonstrated that the observed luminescence quenching is directly related with the Joule heating effect. This work presents for the first time a thermal actuator based on Ga_2O_3 and it intends to be a stimulus for future works on MOEMs applications based on this semiconductor

Trends and outcome of neoadjuvant treatment for rectal cancer: A retrospective analysis and critical assessment of a 10-year prospective national registry on behalf of the Spanish Rectal Cancer Project

Introduction: Preoperative treatment and adequate surgery increase local control in rectal cancer. However, modalities and indications for neoadjuvant treatment may be controversial. Aim of this study was to assess the trends of preoperative treatment and outcomes in patients with rectal cancer included in the Rectal Cancer Registry of the Spanish Associations of Surgeons. Method: This is a STROBE-compliant retrospective analysis of a prospective database. All patients operated on with curative intention included in the Rectal Cancer Registry were included. Analyses were performed to compare the use of neoadjuvant/adjuvant treatment in three timeframes: I)2006–2009; II)2010–2013; III)2014–2017. Survival analyses were run for 3-year survival in timeframes I-II. Results: Out of 14, 391 patients, 8871 (61.6%) received neoadjuvant treatment. Long-course chemo/radiotherapy was the most used approach (79.9%), followed by short-course radiotherapy ± chemotherapy (7.6%). The use of neoadjuvant treatment for cancer of the upper third (15-11 cm) increased over time (31.5%vs 34.5%vs 38.6%, p = 0.0018). The complete regression rate slightly increased over time (15.6% vs 16% vs 18.5%; p = 0.0093); the proportion of patients with involved circumferential resection margins (CRM) went down from 8.2% to 7.3%and 5.5% (p = 0.0004). Neoadjuvant treatment significantly decreased positive CRM in lower third tumors (OR 0.71, 0.59–0.87, Cochrane-Mantel-Haenszel P = 0.0008). Most ypN0 patients also received adjuvant therapy. In MR-defined stage III patients, preoperative treatment was associated with significantly longer local-recurrence-free survival (p < 0.0001), and cancer-specific survival (p < 0.0001). The survival benefit was smaller in upper third cancers. Conclusion: There was an increasing trend and a potential overuse of neoadjuvant treatment in cancer of the upper rectum. Most ypN0 patients received postoperative treatment. Involvement of CRM in lower third tumors was reduced after neoadjuvant treatment. Stage III and MRcN + benefited the most

Indicação de cultivares de feijoeiro-comum baseada na avaliação conjunta de diferentes épocas de semeadura

Os objetivos deste trabalho foram verificar a existência de interação entre genótipos de feijoeiro-comum e épocas de semeadura, avaliar a importância da interação complexa e verificar a necessidade de indicação de cultivares para cada época, em região de altitude intermediária nos estados do Paraná e Santa Catarina. Utilizaram-se avaliações de produtividade de grãos de 16 genótipos, em 12 ensaios realizados em duas épocas de semeadura. As análises de variância foram realizadas com decomposição da interação genótipos x ambientes. A percentagem complexa da interação para os pares de ambientes e também a correlação de Spearman entre épocas foram estimadas por meio de médias de produtividade e parâmetros de estabilidade dos genótipos, obtidos pela metodologia Annicchiarico. Detectaram-se diferenças entre épocas e presença de interação genótipos x épocas, mas com menor importância que as outras interações duplas com genótipos. As correlações de Spearman entre épocas mostraram interação predominantemente simples entre genótipos e épocas. A média da percentagem complexa da interação entre pares de ensaios mostrou que a alteração de classificação dos genótipos dentro de cada época tem a mesma magnitude do que a alteração entre épocas. Não é necessário indicar cultivares de feijoeiro comum para cada época isoladamente na região de estudo