1,977 research outputs found
Evolution of hairpin vortices in a shear flow
Recent experimental studies suggest that the hairpin vortex plays an important (and perhaps dominant) role in the dynamics of turbulent flows near walls. In this study a numerical procedure is developed to allow the accurate computation of the trajectory of a 3-D vortex having a small core radius. For hairpin vortices which are convected in a shear flow above a wall, the calculated results show that a 2-D vortex containing a small 3-D disturbance distorts into a complex shape with subsidiary hairpin vortices forming outboard of the original hairpin vortex. As the vortex moves above the wall, it induces unsteady motion in the viscous flow near the wall: numerical solutions suggest that the boundary-layer flow near the wall will ultimately erupt in response to the motion of the hairpin vortex and in the process a secondary hairpin vortex will be created. The computer results agree with recent experimental investigations
Compressed Data Structures for Dynamic Sequences
We consider the problem of storing a dynamic string over an alphabet
in compressed form. Our representation
supports insertions and deletions of symbols and answers three fundamental
queries: returns the -th symbol in ,
counts how many times a symbol occurs among the
first positions in , and finds the position
where a symbol occurs for the -th time. We present the first
fully-dynamic data structure for arbitrarily large alphabets that achieves
optimal query times for all three operations and supports updates with
worst-case time guarantees. Ours is also the first fully-dynamic data structure
that needs only bits, where is the -th order
entropy and is the string length. Moreover our representation supports
extraction of a substring in optimal time
A Faster Implementation of Online Run-Length Burrows-Wheeler Transform
Run-length encoding Burrows-Wheeler Transformed strings, resulting in
Run-Length BWT (RLBWT), is a powerful tool for processing highly repetitive
strings. We propose a new algorithm for online RLBWT working in run-compressed
space, which runs in time and bits of space, where
is the length of input string received so far and is the number of runs
in the BWT of the reversed . We improve the state-of-the-art algorithm for
online RLBWT in terms of empirical construction time. Adopting the dynamic list
for maintaining a total order, we can replace rank queries in a dynamic wavelet
tree on a run-length compressed string by the direct comparison of labels in a
dynamic list. The empirical result for various benchmarks show the efficiency
of our algorithm, especially for highly repetitive strings.Comment: In Proc. IWOCA201
Criminal Justice in the Supreme Court: A Review of United States Supreme Court Criminal and Habeas Corpus Decisions (October 4, 1999 - October 1, 2000)
Criminal Justice in the Supreme Courts: An Analysis of United States Supreme Court Criminal and Habeas Corpus Decisions (October 2, 2000 - September 30, 2001)
Criminal Justice in the Supreme Court: A Review of United States Supreme Court Criminal and Habeas Corpus Decisions (October 4, 1999 - October 1, 2000)
Acoustic oscillations and dynamo action in the G8 sub-giant EK Eri
We present further evidence of the presence of acoustic oscillations on the
slowly-rotating, over-active G8 sub-giant EK Eri. This star was observed with
the 1-m Hertzsprung SONG telescope, at the Observatorio del Teide for two
different runs of 8 and 13 nights, respectively, and separated by about a year.
We determined a significant excess of power around Hz in the first observing run and we were able to determine the large
separation Hz. No significant excess of power
was instead detected in a subsequent SONG observing season, as also supported
by our analysis of the simultaneous TESS photometric observations. We propose a
new amplitude-luminosity relation in order to account for the missing power in
the power spectrum. Based on the evolutionary stage of this object we argue
that standard dynamo cannot be excluded as a possible origin
for the observed magnetic field.Comment: 8 pages, 8 figures, accepted for publication in A&
Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities
E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success. The von Hippel-Lindau protein (pVHL) is the substrate recognition subunit of the VHL E3 ligase that targets HIF-1α for degradation. We recently reported inhibitors of the pVHL:HIF-1α interaction, however they exhibited moderate potency. Herein, we report the design and optimization, guided by X-ray crystal structures, of a ligand series with nanomolar binding affinities
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