Check-list of European Orthoptera

List of all 974 recognized species of Ensifera (Tettigonioidea: 458, Rhaphidophoroidea: 44, Grylloidea: 91) and Caelifera (Tetrigoidea: 12, Tridactyloidea: 6, Acridoidea: 363) in Europe including information about their distribution.Aufstellung aller 974 derzeitig anerkannten Arten der Ensifera (Tettigonioidea: 458, Rhaphidophoroidea: 44, Grylloidea: 91) and Caelifera (Tetrigoidea: 12, Tridactyloidea: 6, Acridoidea: 363) in Europa mit Angabe der Verbreitungsgebiete

Adaphostin toxicity in a sensitive non-small cell lung cancer model is mediated through Nrf2 signaling and heme oxygenase 1

<p>Abstract</p> <p>Background</p> <p>Preclinical toxicity of adaphostin has been related to oxidative stress. This study investigated the regulatory mechanism underlying adaphostin induction of heme oxygenase 1 (HMOX1) which plays a significant role in modulation of drug-induced toxicity in the non-small cell lung cancer cell line model, NCI-H522.</p> <p>Methods</p> <p>The transcriptional response of NCI-H522 to adaphostin prominently involved oxidative stress genes, particularly HMOX1. Reactive oxygen species (ROS) involvement was additionally established by generation of ROS prior to modulation of adaphostin-toxicity with antioxidants. To identify up-stream regulatory elements of HMOX1, immunofluorescence was used to evaluate nuclear translocation of the transcription factor, NF-E2-related factor 2 (Nrf2), in the presence of adaphostin. The PI3-kinase inhibitor, wortmannin, was employed as a pharmacological inhibitor of this process.</p> <p>Results</p> <p>Generation of ROS provided a substantial foundation for the sensitivity of NCI-H522 to adaphostin. However, in contrast to leukemia cell lines, transcriptional response to oxidative stress was associated with induction of HMOX1, which was dependent on nuclear translocation of the transcription factor, Nrf2. Pretreatment of cells with wortmannin inhibited translocation of Nrf2 and induction of HMOX1. Wortmannin pretreatment was also able to diminish adaphostin induction of HMOX1, and as a consequence, enhance the toxicity of adaphostin to NCI-H522.</p> <p>Conclusions</p> <p>Adaphostin-induced oxidative stress in NCI-H522 was mediated through nuclear translocation of Nrf2 leading to upregulation of HMOX1. Inhibition of Nrf2 translocation by wortmannin inhibited this cytoprotective response, and enhanced the toxicity of adaphostin, suggesting that inhibitors of the PI3K pathway, such as wortmannin, might augment the antiproliferative effects of adaphostin in solid tumors that depend on the Nrf2/ARE pathway for protection against oxidative stress.</p

Observational validation of the diffusive convection flux laws in the Amundsen Basin, Arctic Ocean

The low levels of mechanically driven mixing in many regions of the Arctic Ocean make double diffusive convection virtually the only mechanism for moving heat up from the core of Atlantic Water towards the surface. In an attempt to quantify double diffusive heat fluxes in the Arctic Ocean, a temperature microstructure experiment was performed as a part of the North Pole Environmental Observatory (NPEO) 2013 field season from the drifting ice station Barneo located in the Amundsen Basin near the Lomonosov Ridge (89.58N, 758W). A diffusive convective thermohaline staircase was present between 150 and 250 m in nearly all of the profiles. Typical vertical heat fluxes across the high-gradient interfaces were consistently small, O(1021 )Wm22 . Our experiment was designed to resolve the staircase and differed from earlier Arctic studies that utilized inadequate instrumentation or sampling. Our measured fluxes from temperature microstructure agree well with the laboratory derived flux laws compared to previous studies, which could find agreement only to within a factor of two to four. Correlations between measured and parameterized heat fluxes are slightly higher when using the more recent Flanagan et al. [2013] laboratory derivation than the more commonly used derivation presented in Kelley [1990]. Nusselt versus Rayleigh number scaling reveals the convective exponent, g, to be closer to 0.29 as predicted by recent numerical simulations of single-component convection rather than the canonical 1/3 assumed for double diffusion. However, the exponent appears to be sensitive to how convective layer height is defined.publishedVersio

Winter Vertical Diffusion Rates in the Arctic Ocean, Estimated From 7Be Measurements and Dissipation Rate Profiles

Ocean turbulent mixing is a key process affecting the uptake and redistribution of heat, carbon, nutrients, oxygen and other dissolved gasses. Vertical turbulent diffusivity sets the rates of water mass transformations and ocean mixing, and is intrinsically an average quantity over process time scales. Estimates based on microstructure profiling, however, are typically obtained as averages over individual profiles. How representative such averaged diffusivities are, remains unexplored in the quiescent Arctic Ocean. Here, we compare upper ocean vertical diffusivities in winter, derived from the 7Be tracer-based approach to those estimated from direct turbulence measurements during the year-long Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition, 2019–2020. We found that diffusivity estimates from both methods agree within their respective measurement uncertainties. Diffusivity estimates obtained from dissipation rate profiles are sensitive to the averaging method applied, and the processing and analysis of similar data sets must take this sensitivity into account. Our findings indicate low characteristic diffusivities around 10−6 m2 s−1 and correspondingly low vertical heat fluxes.publishedVersio

Nutrients vs. turbulence, and the future of Arctic Ocean primary production

Poster no. B7 from Forum for Arctic Modeling & Observational Synthesis (Woods Hole Oceanographic Institution, 2-4 November 2016.This poster presents estimates of nitrate fluxes in the Arctic Ocean and speculates on the associated primary production in a future climate

A non-perturbative determination of Z_V and b_V for O(a) improved quenched and unquenched Wilson fermions

By considering the local vector current between nucleon states and imposing charge conservation we determine, for $O(a)$ improved Wilson fermions, its renormalisation constant and quark mass improvement coefficient. The computation is performed for both quenched and two flavour unquenched fermions.Comment: 3 pages, 4 figures, Lattice(2002)(improve

Storms drive outgassing of CO2 in the subpolar Southern Ocean

The subpolar Southern Ocean is a critical region where CO2 outgassing influences the global mean air-sea CO2 flux (FCO2). However, the processes controlling the outgassing remain elusive. We show, using a multi-glider dataset combining FCO2 and ocean turbulence, that the air-sea gradient of CO2 (∆pCO2) is modulated by synoptic storm-driven ocean variability (20 µatm, 1–10 days) through two processes. Ekman transport explains 60% of the variability, and entrainment drives strong episodic CO2 outgassing events of 2–4 mol m−2 yr−1. Extrapolation across the subpolar Southern Ocean using a process model shows how ocean fronts spatially modulate synoptic variability in ∆pCO2 (6 µatm2 average) and how spatial variations in stratification influence synoptic entrainment of deeper carbon into the mixed layer (3.5 mol m−2 yr−1 average). These results not only constrain aliased-driven uncertainties in FCO2 but also the effects of synoptic variability on slower seasonal or longer ocean physics-carbon dynamics.publishedVersio

Global patterns of diapycnal mixing from measurements of the turbulent dissipation rate

The authors present inferences of diapycnal diffusivity from a compilation of over 5200 microstructure profiles. As microstructure observations are sparse, these are supplemented with indirect measurements of mixing obtained from (i) Thorpe-scale overturns from moored profilers, a finescale parameterization applied to (ii) shipboard observations of upper-ocean shear, (iii) strain as measured by profiling floats, and (iv) shear and strain from full-depth lowered acoustic Doppler current profilers (LADCP) and CTD profiles. Vertical profiles of the turbulent dissipation rate are bottom enhanced over rough topography and abrupt, isolated ridges. The geography of depth-integrated dissipation rate shows spatial variability related to internal wave generation, suggesting one direct energy pathway to turbulence. The global-averaged diapycnal diffusivity below 1000-m depth is O(10?4) m2 s?1 and above 1000-m depth is O(10?5) m2 s?1. The compiled microstructure observations sample a wide range of internal wave power inputs and topographic roughness, providing a dataset with which to estimate a representative global-averaged dissipation rate and diffusivity. However, there is strong regional variability in the ratio between local internal wave generation and local dissipation. In some regions, the depth-integrated dissipation rate is comparable to the estimated power input into the local internal wave field. In a few cases, more internal wave power is dissipated than locally generated, suggesting remote internal wave sources. However, at most locations the total power lost through turbulent dissipation is less than the input into the local internal wave field. This suggests dissipation elsewhere, such as continental margins

Correlation functions of scattering matrix elements in microwave cavities with strong absorption

The scattering matrix was measured for microwave cavities with two antennas. It was analyzed in the regime of overlapping resonances. The theoretical description in terms of a statistical scattering matrix and the rescaled Breit-Wigner approximation has been applied to this regime. The experimental results for the auto-correlation function show that the absorption in the cavity walls yields an exponential decay. This behavior can only be modeled using a large number of weakly coupled channels. In comparison to the auto-correlation functions, the cross-correlation functions of the diagonal S-matrix elements display a more pronounced difference between regular and chaotic systems