Relationship Between Anti-DFS70 Autoantibodies and Oxidative Stress

Background: The anti-DFS70 autoantibodies are one of the most commonly and widely described agent of unknown clinical significance, frequently detected in healthy individuals. It is not known whether the DFS70 autoantibodies are protective or pathogenic. One of the factors suspected of inducing the formation of anti-DFS70 antibodies is increased oxidative stress. We evaluated the coexistence of anti-DFS70 antibodies with selected markers of oxidative stress and investigated whether these antibodies could be considered as indirect markers of oxidative stress. Methods: The intensity of oxidative stress was measured in all samples via indices of free-radical damage to lipids and proteins such as total oxidant status (TOS), concentrations of lipid hydroperoxides (LPH), lipofuscin (LPS), and malondialdehyde (MDA). The parameters of the non-enzymatic antioxidant system, such as total antioxidant status (TAS) and uric acid concentration (UA), were also measured, as well as the activity of superoxide dismutase (SOD). Based on TOS and TAS values, the oxidative stress index (OSI) was calculated. All samples were also tested with indirect immunofluorescence assay (IFA) and 357 samples were selected for direct monospecific anti DFS70 enzyme-linked immunosorbent assay (ELISA) testing. Results: The anti-DFS70 antibodies were confirmed by ELISA test in 21.29% of samples. Compared with anti-DFS70 negative samples we observed 23% lower concentration of LPH (P =.038) and 11% lower concentration of UA (P =.005). TOS was 20% lower (P =.014). The activity of SOD was up to 5% higher (P =.037). The Pearson correlation showed weak negative correlation for LPH, UA, and TOS and a weak positive correlation for SOD activity. Conclusion: In samples positive for the anti-DFS70 antibody a decreased level of oxidative stress was observed, especially in the case of samples with a high antibody titer. Anti-DFS70 antibodies can be considered as an indirect marker of reduced oxidative stress or a marker indicating the recent intensification of antioxidant processes

Different faces of genocide in the age of two totalitarian regimes – national socialism and communism

Multidimensionality of the problem, which undoubtedly genocide is, requires attempts to characterize and analyze the causes and consequences of this extreme form of violence. Despite growing awareness and knowledge of society, the risk of acts of genocide, is still very real. In the article there are presented different faces of genocide: Holokaust, genocidium atrox and cultural genocide. These various examples and different types of crime, despite the differences in the course, the method of extermination, the tools used and the reasons, in effect, lead to the same i.e. depriving people of their most important rights – the right to life

PRACTICAL USE OF COMMAND USING THE EXAMPLE OF THE CONTEMPORARY DIMENSION OF INFORMATION WARS

The paper discusses the issues related to the practical application of the process of command, which was presented with the example of the contemporary dimension of information wars. In this paper, the following thesis has been adopted: when analysing today's armed conflicts, it is possible to observe a decisive move away from mass armies towards digital armies. Five major factors determining the described process have been identified and their characteristics have been discussed. The paper summarises the accumulated facts, confirming the thesis that the process of transition from mass armies is constantly progressing. This, in turn, is fully reflected in contemporary armed conflicts

The tendency to eating disorders and the regulation of emotions and the level of alexithymia in a group of women.

Tematyka niniejszej pracy dotyczy zagadnienia zaburzeń odżywiania w kontekście trudności w regulacji emocji. Celem przeprowadzonego badania było sprawdzenie czy istnieje zależność pomiędzy skłonnościami do zaburzeń odżywiania a trudnościami w regulacji emocji, ruminacją i poziomem aleksytymii. Badaniem objęto grupę 317 kobiet w wieku (M=23,3, SD=3,7). Pomiaru wymienionych zmiennych dokonano za pomocą Kwestionariusza do Badań Zaburzeń Odżywiania u Kobiet autorstwa Pawłowskiej i Potembskiej, Kwestionariusza Poznawczej Regulacji Emocji autorstwa Garnefski, Kraaji, Spinohoven, Kwestionariusza Trudności w Regulacji Emocji autorstwa Gratz i Roemer oraz Toronto Alexithymia Scale TAS – 20 autorstwa Taylor, Bagby, Parker. Uzyskane wyniki wskazują, że istnieje pozytywna korelacja pomiędzy skłonnościami do zaburzeń odżywiania a trudnościami w regulacji emocji i ruminacją. Podobną zależność zaobserwowano pomiędzy skłonnościami do zaburzeń odżywiania a poziomem aleksytymii. Dowiedziono również, że istnieją istotne statystycznie, dodatnie korelacje pomiędzy poszczególnymi aspektami trudności w regulacji emocji a poszczególnymi rodzajami zaburzeń odżywiania. Co więcej, wystąpiła również różnica pomiędzy osobami o niskim versus wysokim poziomem aleksytymii w zakresie skłonności do zaburzeń odżywiania. Uzyskane wyniki mogą znaleźć zastosowanie w psychoterapii osób ze skłonnościami do zaburzeń odżywiania.The subject of this thesis refers to eating disorders in the context of diffculties in emotion regulation. The purpose of the conducted research was verfication whether there exist correlation between tendency towards eating disorderd and difficulties in emotion regulation, rumination and level of alexithymia. There were 317 women tested aged (M=23,3, SD=3,7). Measurement of mentioned variables was conducted using: the Questionnaire for the Study of Eating Disorders in Women by Pawlowska and Potembska, the Cognitive Emotion Regulation Questionnaire by Garnefski, Kraaji, Spinohoven, the Difficulties in Emotion Regulation Scale by Gratz and Roemer and the Toronto Alexithymia Scale TAS - 20 by Taylor, Bagby, Parker.Received results suggest that exists a positive correlation between tendency to eating disorder, difficulties in emotion regulation and rumination. Similar correlation was observed between tendency to eating disorders and level of alexithymia. It has also been proven that there are statistically relevant correlation between particular types of eating disorders within difficulties in emotion regulation. Moreover, a difference occurred between persons with high or low level of alexithymia regarding tendency to eating disorders. Obtained results can be applied in psychotherapy for eating disorders

Contribution à la mise au point des conditions d'hydrolyse et de dérivation du monophosphoryl lipide A (MPL) par micro-ondes pulsées

CHATENAY M.-PARIS 11-BU Pharma. (920192101) / SudocSudocFranceF

Traitement par échange plasmatique de l'insuffisance rénale aiguë associée au myélome multiple (données du Registre de la Société française d'hémaphérèse et pharmacocinétique des chaînes légères libres monoclonales)

Une insuffisance rénale aiguë (IRA) peut révéler un myélome multiple (MM), ou survenir au cours d'une rechute ou d'un échappement thérapeutique. L'IRA réduit de moitié l'espérance de vie (médiane 10-20 mois), et va souvent de pair avec une réduction notable de qualité de vie, notamment pour les patients requérant durablement une épuration extra-rénale. Dans la majorité des observations, l'IRA est la conséquence d'une tubulopathie myélomateuse dont les principaux déterminants sont les caractéristiques intrinsèques de la chaîne légère libre (CLL) monoclonale et sa concentration sérique. Les modalités optimales de la prise en charge spécifique de l'IRA au cours du myélome multiple (IRA/MM), et le bénéfice précis de la soustraction des CLL par échanges plasmatiques (EP) sont encore débattus. Deux objectifs ont été assignés à ce travail : d'une part, décrire rétrospectivement une cohorte de patients identifiés dans le Registre de la Société française d'Hémaphérèse et traités par EP pour IRA/MM. D'autre part, à l'occasion d'une étude pilote prospective, établir l'impact pharmacocinétique des EP chez des patients en situation d'IRA/MM sur la concentration des CLL monoclonales dans le sérum et le plasma effluent, mesurée à l'aide d'une méthode néphélémétrique . Quarante-trois observations ont été colligées à partir du Registre : 26 hommes et 17 femmes, d'âge médian 68 (40-85) ans ; dans 27 observations (63%) l'IRA révélait le MM ; la médiane de la créatinine plasmatique était initialement à 600 mmol/l, et 17 patients requièrent une dialyse au cours du 1er mois. Le nombre médian d'EP effectué est de 3. A l'issue de la première année, 24 patients (58%) sont décédés (12/17 dialysés à J0 vs. 12/26 parmi les non-dialysés à J0, p>0,05). Dans cette série, la prise en charge pour rechute de MM, le nombre d'EP effectués, leur espacement et l'existence d'une insuffisance rénale préalable n'influencent pas la survie globale et la fonction rénale à 1 an. Quatre patients ont été inclus dans l'étude prospective (dont 1 à deux reprises). La concentration initiale de CLL monoclonale se distribue entre 2700 et 20 000 mg/l. Le traitement du MM par EP et Dexaméthasone (seul ou combiné à thalidomide (T), melphalan ou T et bortezomib) s'accompagne d'un abaissement rapide et marqué de la CLL monoclonale (80 à 93% de la concentration initiale après 3 EP). La masse moyenne de CLL monoclonale soustraite est de 21 g (12-40) au 1er EP et de 6,5 g (3-10) au 3ème EP. Une réascension variable de la concentration de CLL est observée entre deux EP consécutifs. En conclusion, les EP semblent soustraire promptement et significativement les CLL au cours de l'IRA/MM, et apporte des arguments pour réévaluer le bénéfice clinique de l'aphérèse sur le pronostic rénal.TOULOUSE3-BU Santé-Centrale (315552105) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Biobased Ionic Liquids with Abietate Anion

The present study is focused on the utilization of naturally occurring abietic acid in the synthesis of high added-value compounds with attractive characteristics. The synthesis of ILs derived from abietic acid was conducted using ion-exchange or neutralization methods, and the products were obtained with high yields exceeding 85%. The study confirmed strong influence of the chemical structure on the physicochemical properties of the obtained compounds, such as solubility, thermal stability, and phase transitions. The results also revealed excellent deterrent properties of ILs with abietate anions toward <i>S. granarius</i>, <i>T. confusum</i>, and <i>T. granarium</i>, reaching or exceeding the values calculated for azadirachtin. The best results were achieved for cations containing long alkyl substituentstetraalkylammonium and 1-alkyl-3-methylimidazolium cations. Additionally, the obtained compounds exhibited antioxidant properties in the DPPH radical scavenging assay. The highest activity was observed for tetraalkylammonium cations. The obtained results allow for a conclusion that abietate ionic liquids with both antifeedant and antioxidant activity can be successfully implemented into storage crop protection