Inflammatory breast cancer-comparing the effectivity of preoperative docetaxel-epirubicine protocol to conventional antracycline-containing chemotherapy to achieve clinical benefit and complete pathological response

Our retrospective analysis compared the effectiveness of conventional antracycline-containing protocols (A+) and docetaxel/epirubicine (TE) as primary systemic chemotherapies (PSCT) for inflammatory breast cancer (IBC). Seventy IBC patients received either A + (n = 48) or TE (n = 22) as PSCT. The objective clinical response and clinical benefit rate of treated patients were 54.3% (A+: 54,2% vs. TE: 54,5%; p = 0,28) and 92.8% (A+: 91,7% vs. TE: 95,5%; p = 0,57), respectively. The clinical complete response rate (cCR) was 23.2% (A+: 27,1% vs. TE:4,5%; chi (2) = 4,79; p = 0,03) with 7.14% (A+: 10,4% vs. TE:0%; chi (2) = 2,47; p = 0,12) of pathological complete responses (pCR). The median progression free (PFS)/local progression free (LPFS)/overall survival (OS) was 2.0/5.4/4.0 years, respectively. Patients achieving cCR had a tendency for better survival parameters than patients with less than cCR. Response rates or survival data were not statistically different in the two chemotherapy (CT) treatment groups. The survival was not influenced by the number of CT cycles in either protocols. In this set of patients, the clinical efficacy of the two alternative primary systemic chemotherapies (A + and TE) is equivalent in the treatment of inflammatory breast cancer (IBC), despite of the significant difference in favour of A + noticed in CRs. Six cycles of CT could be enough for patients achieving CR, however sequential pre- and/or postoperative CT with non cross-resistant drugs should be considered for non-responders

Effect of nano-sized, elemental selenium supplement on the proteome of chicken liver

The nano-sized (100-500 nm) selenium has higher bioavailability and relatively lower toxicity compared to other selenium forms. The objective of the present study was to compare liver proteome profiles of broiler chicken fed with control diet without Se supplementation and diet supplemented with nano-Se with 4.25 mg/kg DM. Differential proteome analyses were performed by two-dimensional gel electrophoresis (2D-PAGE) followed by tryptic digestion and protein identification by liquid chromatography-mass spectrometry (LC-MS). Seven hundred and eight spots were detected, and 18 protein spots showed significant difference in their intensity (p < 0.05) between the two groups. In response to nano-Se supplementation, the expression of 8 proteins was higher, and 5 proteins were lower in nano-Se supplemented group compared to control group. The functions of the differentially expressed proteins indicate that the high dose of selenium supplementation induced a dietary stress. Selenium supplementation may influence the metabolism of fatty acids and carbohydrates and antioxidant system, and increase the quantity of cytoskeletal actin and the expression of actin regulatory protein as well

Effect of nano-sized, elemental selenium supplement on the proteome of chicken liver

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Speciation and structure of tin(ii) in hyper-alkaline aqueous solution

The structure of tin(II) hydroxido complex forming in hyper-alkaline aqueous solutions (0.2 CNaOH 12 mol⋅dm-3) has been determined by EXAFS, Raman and Mössbauer spectroscopy, and the general composition by potentiometric titrations. Experimental work was supplemented by computational means. 10 The mean Sn-O distance in the non-linear complex is remarkably short, 2.078 Å. From single crystal X-ray data of O-coordinated Sn(II) compounds, for the given coordination numbers of N = 2 and 3, the bond distances were found to cover a relatively wide range (much wider than normal). The experimentally 15 determined Sn-O bond distance is within the range of both. Thermodynamic studies using H2/Pt electrode up to free hydroxide concentrations of 1 mol⋅dm-3 have shown the presence of a single complex with a tin(II):hydroxide ratio of 1:3. These findings together with Raman and Mössbauer spectroscopic 20 measurements supplemented by quantum mechanical calculations proved that the predominating complex is [Sn(OH)3]– and that the presence of [SnO(OH)]– cannot be experimentally proven. It is also shown that at pH values above 13 the structure of the predominating trihydroxidotin(II) complex is not affected by the 25 presence of high concentrations of chloride ions