The body weight change during the first year of HEMODIALYSIS IS a strong predictor of patient survival

Hemodialysis patients are exposed to a high risk of death. We report the influence of the body weight (BW) change (Δ) on the survival in an incident HD patient cohort.Between January 2000 to 2009, 251 patients (age=65,8±14,8 y.o.; F/M=93/158; diabetes=36%) survived at least one year after HD onset and were followed for 44,9 months. The prescribed BW decreased by 6.5±5% at Week 8 (W8) and then increased again. From W8 to W52, the BW Δ was+1,9±7,4%. According to the median of W52-W8 BW Δ (+2.35%), the Kaplan Meier analysis (see figure below) displayed a significant better survival in patients with a BW Δ above the median. These two groups were not different according to age, diabetes or cardiovascular event history but had a significant higher interdialytic weight gain and protein intake. In the Cox model analysis the patient overall mortality was related to age (p<0.0001), to the W52W8 BW Δ (p=0.017), to the CRP level at W52 (p=0.035) and to serum albumin at W52 (p=0.036). Hence weight gain during the first year of HD treatment was found a strong predictor of survival in HD patients. It was associated with a better food intake whereas the patient case-mix was not different. These data highlight the need for understanding what drives food intake in dialysis patients and for careful nutritional follow-up and support in incident HD patients.fx

13Th International Conference On Conservative Management Of Spinal Deformities And First Joint Meeting Of The International Research Society On Spinal Deformities And The Society On Scoliosis Orthopaedic And Rehabilitation Treatment – Sosort-Irssd 2016 Meeting

PubMe

Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

International audienceThe aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed

ILC Reference Design Report Volume 1 - Executive Summary

The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2s^-1. This report is the Executive Summary (Volume I) of the four volume Reference Design Report. It gives an overview of the physics at the ILC, the accelerator design and value estimate, the detector concepts, and the next steps towards project realization.The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2s^-1. This report is the Executive Summary (Volume I) of the four volume Reference Design Report. It gives an overview of the physics at the ILC, the accelerator design and value estimate, the detector concepts, and the next steps towards project realization