NUTRITIONAL LEVELS AND SPINE CURVATURE DISORDERS AMONG PRESCHOOL CHIDLREN

The modern way of life lead to the emergence of hypokinesis, obesity or various conditions and spine curvature disorders which are more and more present among younger children. The aim of this research was to determine the connection between nutritional levels and kyphosis and lordosis among preschool children. The sample of participants included of 50 boys and girls, preschoolers aged 6 to 7, who attend the Jelica Obradović Preschool in Mladenovac. Previous approval was obtained from their parents and teachers for participation in this study. To evaluate nutritional levels, the body mass index was used, which divided the participants into four categories: underweight, normal weight, overweight and obese. Somatoscopy was used to evaluate posture, along with a wooden frame to which a net with square decimeters was attached. Based on the results of this test, the following variables were obtained: normal posture, poor posture, first level of severity and poor posture, second level of severity.  To determine the connection, or possible influence of the nutritional levels on body posture, the Chi square test was used. The results indicate that there is no statistically significant connection between nutritional levels and kyphosis and lordosis for this group of preschool children. This could indicate that obesity and underweight do not influence the occurrence of spine curvature disorders independently, but probably in combination with other factors such as heredity, physical inactivity, etc

Developmental aspects of innovation in preschool education

This work is based on the modern institutional concept of the preschool physical education programme, which is realized in the kindergarten 'Sunce' courtyard, in the preschool institution 'Jelica Obradović' in Mladenovac. Namely, in the courtyard of the mentioned kindergarten, an innovative system for physical exercise named 'Sun's Playroom - Planetary Polygon' was constructed and installed. Two groups of children of the same age, with different motor experiences, were practicing daily for 30 minutes, on the mentioned system, for 20 days. An assessment of children's motor skills on the given system was performed at the beginning and at the end of the cycle. In addition to the assessment of motor skills and the control level over motor functions, the cognitive process of information acquisition and the level of communication and socialization among children were also monitored. The conclusion reached is that this kind of a new complex for exercise and learning in the open space has a significant impact on the development of psycho-motorics in children, as well as on the cognitive functions, cultural and communication skills

Copper Electrodeposition onto Palladium from a Deep Eutectic System Based on Choline Chloride

Recently, there has been an increasing interest in developing nonaqueous electrolytes which have been widely employed as an alternative media for a range of metals and metal alloys electrodepositions. A promising and new class of electrolytes among ionic liquids (Ils) are deep eutectic solvents (DESs)1 . The purpose of the copper deposition study from DESs is the application of copper coating and copper alloys in both, industry and fundamental research. In this work, the electrochemical deposition of copper onto palladium working substrate from ChCl/EG (1:2 ratio) DES electrolyte at 50°C was investigated. Additionally, the Cu(II) electroreduction process was studied by potentiodynamic measurements, cyclic voltammetry, chronoamperometry, in the electrolytes with different concentrations of Cu(II) ions ranging from 0.1 M to 0.5 M. The cyclic voltammetry results indicated that the bulk deposition of Cu(II) begins to occur at around –0.080 V vs. Cu. It was found that copper deposition onto the Pd cathode from ChCl:EG electrolyte under potentiostatic conditions is achievable. Data collected from X-ray diffraction (XRD) analysis proved that the cathodic deposits are composed of Cu and CuPd intermetallic. CuPd alloys with different Pd-Cu ratios were prepared by constant potential of –0.100 V vs. Cu from ChCl/EG containing 0.1 M and 0.5 M Cu(II). It is worth noting that the Xray data indicated that the composition of the produced Pd-Cu films could be varied by changing the concentration of Cu(II) ions in the electrolyte or changing the deposition mode

Spectroscopic and quantum chemical elucidation of newly synthesized 1-aryl-3-methyl-3-phenylpyrrolidine-2,5-diones as potential anticonvulsant agents

Novel succinimide derivatives were synthesized from 3-methyl-3-phenylsuccinic acid and substituted anilines under solvent-free conditions by using microwave irradiation. All obtained compounds were characterized by ultraviolet (UV), Fourier-transform infrared (FT-IR), H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopy as well as by elemental analysis. The influence of the substituent electronic effects on spectroscopic data was analyzed by applying the Hammett equation. Moreover, a detailed interpretation and comparison of experimentally obtained and theoretically calculated FT-IR, UV and NMR spectra was performed. Density functional theory (DFT) calculated data of the investigated succinimides were obtained and analyzed in order to determine their structural, spectroscopic and electronic properties. Furthermore, ADMET factor profiling and in-silico prediction of potential biological activities of novel succinimide derivatives have been performed

In vitro/in silico ispitivanje lekovite supstance i tableta telmisartana

Telmisartan acts as antagonist of angiotensin II type-1 (AT1) receptor and is indicated in the treatment of essential hypertension. In order to rationalize the pharmacokinetic characteristics, pharmacological activity, as well as the optimal method of administration of this drug, knowledge of its physico-chemical properties is needed. The assessment of the drug physico-chemical parameters on the basis of its chemical structure at different pH values, which are characteristic for physiological conditions, enables the prediction of its behaviour in the body before the drug is synthesized. Such assessment of its physico-chemical parameters during the preformulation phase is important for the development of a safe, efficient and stable dosage form. Based on the calculated pKa values, this paper is focused on the prediction of distribution of the ionized and nonionized drug species in the pH gradient of 1 to 8 and the calculation of physico-chemical parameters such as telmisartan lipophilicity (log P) and intrinsic solubility (log S0). On the basis of the calculated physicochemical parameters, the pH-dependent solubility and lipophilicity curves of this medicinal substance have been constructed. The assessment of intrinsic dissolution rate and dissolution rate of telmisartan from tablets was used to investigate the influence of medium pH values applied on the model substance behavior. The results obtained from predicting the physico-chemical properties and from experimental evaluation of the model substance intrinsic dissolution rate and telmisartan dissolution rate from tablets, indicate the importance of physico-chemical characterization of the active substance during the preformulation investigation for predicting the drug behaviour in the body (absorption, bioavailability, tissue penetration, elimination). .Telmisartan deluje kao antagonista angiotenzinskog II tipa-1 (AT1) receptora i indikovan je u terapiji esencijalne hipertenzije. Da bi se razjasnile farmakokinetičke osobine, farmakološka aktivnost, kao i optimalni način primene ove lekovite supstance, potrebno je poznavanje njenih fizičko-hemijskih osobina. Određivanje fizičko-hemijskih parametara lekovite supstance na osnovu hemijske strukture pri različitim pH vrednostima koje su karakteristične za fiziološke uslove omogućava predviđanje njenog ponašanja u organizmu pre nego što se lekovita supstanca sintetiše. Određivanje fizičko-hemijskih parametara u toku preformulacionih ispitivanja značajno je za razvijanje bezbednog, efikasnog i stabilnog farmaceutskog oblika. U ovom radu je, na osnovu izračunatih pKa vrednosti, izvršeno predviđanje raspodele jonizovanih i nejonizivanog oblika lekovite supstance u pH gradijentu od 1 do 8 i izračunavanje fizičko-hemijskih parametara telmisartana kao što su lipofilnost (log P) i osnovna rastvorljivost (log S0). Na osnovu izračunatih fizičko-hemijskih parametara konstruisane su krive pH-zavisne rastvorljivosti i lipofilnosti ove lekovite supstance. Određivanjem osnovnih brzina rastvaranja i brzina rastvaranja telmisartana iz tableta ispitan je uticaj pH vrednosti primenjenog medijuma na ponašanje model supstance. Rezultati dobijeni predviđanjem fizičko-hemijskih osobina, kao i eksperimentalnim određivanjem osnovne brzine rastvaranja model supstance i brzine rastvaranja telmisartana iz tableta ukazuju na značaj fizičko-hemijske karakterizacije aktivne supstance tokom preformulacionih ispitivanja za predviđanje njenog ponašanja u organizmu (resorpcije, biološke raspoloživosti, penetracije u tkiva, eliminacije)

Poređenje biosorpcije sa Aureobasidium pullulans soj CH-1 i polimer sorpcije na Poli(GMA-co-EGMA)teških metala iz otpadnih voda

The intact microbial cells as well as derived microbial products can be highly efficient bioacummulators of both soluble and participate forms of metals, especially from dilute external concentrations (1,2). The reason for testing Aureobasidium pullulans as a biosorbent is the fact that this fungus presents a ubiquitous saprophite that occurs commonly in the phytoshere (3). Therefore, it has enabled the use of carbohydrate wastes as substrates for the production of pullulan such as the peat hydrolysate. The metal removal and recovery processes include: precipitation, adsorption and biosorption, electrowinning and electocoagulation, cementation, membrane separation, solvent extraction and ion exchange (4). Galvanic waste effluent contain heavy metals ions, such as Cu2f, Cr1+, Cr6+, Cd2+, Ni2+, etc., which present environmental hazard. Having all this in mind, the aim of this paper is to examine the possibility of applying Aureobasidium pullulam CH-1 (Collection of Microorganisms, IChTM) as a biosorbent of metals and biosynthesis of pullulan at the same time on peat hydrolisate, distribution of sorbed metals between biomass and pullulan, as well as the correlation between biosorption Aureobasidium pullulam CH-1 and polymer sorption on poly(GMA-co-EGDMA)-en of heavy metals from galvanic waste effluent.Ispitivanje Aureobasidium pullulans, soj CH-1 kao biosorbenta je urađeno na kiselom hidrolizatu treseta sa lokaliteta Vlasinskog jezera. Kiseli hidrolizat treseta je dobijen na isti način kao i otpadne vode pri industrijskoj obradi treseta. Rezultati su pokazali da Aureohusidium pullulans, soj CH-1 može istovremeno da vrši biosorpciju metala i biosintezu pululana pri fermentacijama na kiselom hidrolizatu treseta. U cilju poređenja, za sorpciju teških metala iz galvanskih otpadnih voda, osim Aureobasidium pullulans soj CH-1 korišćen je i makroporozni kopolimer, poli(gicidilmetakrilat-co-etilenglikoldimetakrilat) modifikovan sa etilendiaminom, poli(GMA-co-EGDMA)-en. Rezultati uporednih eksperimenata biosorpcije na Aureobasidium pullulans soj CH-1 i sorpcije na polimernom sorbentu su pokazali da se oba postupka mogu uspešno koristiti za uklanjanje teških metala iz galvanskih otpadnih voda. Pokazalo se da je pri datim eksperimentalnim uslovima, za uklanjanje cinka uspešniji postupak biosorpcija, dok je poli(GMA-co-F.GDMA)-en znatno efikasniji za uklanjanje bakra iz galvanskih otpadnih voda

Poređenje biosorpcije sa Aureobasidium pullulans soj CH-1 i polimer sorpcije na Poli(GMA-co-EGMA)teških metala iz otpadnih voda

The intact microbial cells as well as derived microbial products can be highly efficient bioacummulators of both soluble and participate forms of metals, especially from dilute external concentrations (1,2). The reason for testing Aureobasidium pullulans as a biosorbent is the fact that this fungus presents a ubiquitous saprophite that occurs commonly in the phytoshere (3). Therefore, it has enabled the use of carbohydrate wastes as substrates for the production of pullulan such as the peat hydrolysate. The metal removal and recovery processes include: precipitation, adsorption and biosorption, electrowinning and electocoagulation, cementation, membrane separation, solvent extraction and ion exchange (4). Galvanic waste effluent contain heavy metals ions, such as Cu2f, Cr1+, Cr6+, Cd2+, Ni2+, etc., which present environmental hazard. Having all this in mind, the aim of this paper is to examine the possibility of applying Aureobasidium pullulam CH-1 (Collection of Microorganisms, IChTM) as a biosorbent of metals and biosynthesis of pullulan at the same time on peat hydrolisate, distribution of sorbed metals between biomass and pullulan, as well as the correlation between biosorption Aureobasidium pullulam CH-1 and polymer sorption on poly(GMA-co-EGDMA)-en of heavy metals from galvanic waste effluent.Ispitivanje Aureobasidium pullulans, soj CH-1 kao biosorbenta je urađeno na kiselom hidrolizatu treseta sa lokaliteta Vlasinskog jezera. Kiseli hidrolizat treseta je dobijen na isti način kao i otpadne vode pri industrijskoj obradi treseta. Rezultati su pokazali da Aureohusidium pullulans, soj CH-1 može istovremeno da vrši biosorpciju metala i biosintezu pululana pri fermentacijama na kiselom hidrolizatu treseta. U cilju poređenja, za sorpciju teških metala iz galvanskih otpadnih voda, osim Aureobasidium pullulans soj CH-1 korišćen je i makroporozni kopolimer, poli(gicidilmetakrilat-co-etilenglikoldimetakrilat) modifikovan sa etilendiaminom, poli(GMA-co-EGDMA)-en. Rezultati uporednih eksperimenata biosorpcije na Aureobasidium pullulans soj CH-1 i sorpcije na polimernom sorbentu su pokazali da se oba postupka mogu uspešno koristiti za uklanjanje teških metala iz galvanskih otpadnih voda. Pokazalo se da je pri datim eksperimentalnim uslovima, za uklanjanje cinka uspešniji postupak biosorpcija, dok je poli(GMA-co-F.GDMA)-en znatno efikasniji za uklanjanje bakra iz galvanskih otpadnih voda

Elektrohemijsko taloženje Nd i Pr na W iz fluoridnih rastopa

Electrodeposition of neodymium and praseodymium metal from molten NdF3+PrF3+LiF+ 0.5wt.%Pr6O11+0.5wt.%Nd2O3 electrolytes on W was investigated using voltammetry at 1050 °C. The square wave voltammetry confirmed that Nd electrodeposition is a two-step reduction process: first, involving one electron exchange (Nd(III)→Nd(II)) and second, involving two electrons exchange (Nd(II)→Nd(0)). However, praseodymium deposition proceeds as an one-step process involving exchange of three electrons (Pr(III)→Pr(0)). Nd and Pr metals were electrodeposited applying potentiostatic mode. The working electrode surface was analyzed by X-ray diffraction after Nd and Pr co-deposition.Elektrohemijsko taloženje neodijuma i prazeodijuma iz fluoridnog NdF3+PrF3+LiF+ 0.5wt.%Pr6O11+0.5wt.%Nd2O3 rastopa na W radnoj elektrodi ispitivano je pomoću voltametrijskih tehnika na 1050 °C. Voltametrija sa pravougaonim talasima (SWV, square wave voltammetry) potvrdila je da je elektrohemijsko taloženje Nd proces koji se odvija u dva koraka: prvi, uključuje razmenu od jednog elektrona (Nd(III) → Nd(II)) i drugi korak, uključuje razmenu dva elektrona (Nd(II) → Nd(0)). Međutim, taloženje prazeodijuma uključuje izmenu tri elektrona (Pr(III) → Pr(0)) u jednom koraku. Nd i Pr su elektrohemijski taloženi primenom potenciostatskog režima. Nakon elektrohemijskog taloženja Nd i Pr površina radne elektrode analizirana je rengensko-difrakcionom tehnikom.XII YuCorr International Conference, September 13-16, 2021, Tara Mountain, Serbia, http://sitzam.org.rs/YUCORR

Formation of the honeycomb-like MgO/Mg(OH)(2) structures with controlled shape and size of holes by molten salt electrolysis

Synthesis of the honeycomb-like MgO/Mg(OH)(2) structures, with controlled shape and size of holes, by the electrolysis from magnesium nitrate hexahydrate melt onto glassy carbon is presented. The honeycomb-like structures were made up of holes, formed from detached hydrogen bubbles, surrounded by walls, built up of thin intertwined needles. For the first time, it was shown that the honeycomb-like structures can be obtained by molten salt electrolysis and not exclusively by electrolysis from aqueous electrolytes. Analogies with the processes of the honeycomb-like metal structures formation from aqueous electrolytes are presented and discussed. Rules established for the formation of these structures from aqueous electrolytes, such as the increase of number of holes, the decrease of holes size and coalescence of neighbouring hydrogen bubbles observed with increasing cathodic potential, appeared to be valid for the electrolysis of the molten salt used