Impact of Xenoestrogens on Reproductive Health

Xenoestrogens such as phthalates, parabens, bisphenol A, dichlorodiphenyltrichloroethane, and dioxins are compounds found in ordinary substances such as detergents, cosmetics, plastics, pesticides and herbicides (Sonnenschein & Soto, 1998). Estrogen is a vital component in the development of the male and female reproductive system. However, xenoestrogens mimic endogenous estrogenic signaling and exhibit endocrine disrupting properties that may cause long-lasting repercussions on human reproductive health. Xenoestrogen bind to both intracellular and membrane-bound estrogen receptors resulting in an inappropriate activation of tissue-specific estrogenic responses, leading to low sperm count in males and precocious puberty and polycystic ovarian syndrome in females (Shanle & Xu, 2011). Although the pathways of many xenoestrogens mechanism are unknown, the detrimental outcomes on reproductive health are evident

Whiting Farm Renewable Energy Report

This report provides an analysis of the current electrical and heating usage at Whiting Farm. The data gathered from the analysis is used to evaluate the efficacy of alternative energy sources to offset or completely replace Whiting Farm’s dependence on grid-drawn electricity and propane. We found that solar power is the most cost-effective source of alternative electricity production so we recommend the installation of a 15 kilowatt (kW) array from ReVision Energy. A wind turbine produces far less electricity, but serves as a powerful educational tool, so we recommend a Pika T701 1.5 kW turbine from Pika Energy. Geothermal heating systems are 300-400% more efficient than conventional propane-powered heating systems, Thus we recommend a mixture of air and ground source heat pumps be installed to heat the various buildings

Relación de la conciencia de enfermedad y expectativas del tratamiento con la eficacia y el seguimiento de la intervención en trastornos del espectro esquizofrénico

Este trabajo estudió las relaciones entre la conciencia de enfermedad, las expectativas sobre la eficacia del tratamiento psicofarmacológico, el seguimiento de los tratamientos y la eficacia clínica en personas con trastornos del espectro esquizofrénico. Se registraron altas correlaciones positivas entre las variables mencionadas. Además, se estudió la posible influencia de la presencia de antidepresivos, benzodiacepinas o antiepilépticos junto con el tratamiento neuroléptico. Se observó que solamente la inclusión de fármacos antidepresivos al tratamiento neuroléptico mejoró la conciencia de enfermedad, las expectativas sobre el tratamiento psicofarmacológico, el seguimiento de los tratamientos y la eficacia clínica.This work studied the relationships between illness awareness, expectations about the efficacy of psychopharmacological treatment, treatments follow-up and clinical efficacy in people with schizophrenia spectrum disorders. High positive correlations were found between the variables mentioned. In addition, this work examined the effects of the addition of antidepressants, benzodiazepines or antiepileptic drugs to neuroleptic treatment. It was observed that only the inclusion of antidepressants to neuroleptic treatment improved illness awareness, expectations about psychopharmacological treatment, treatments follow-up and clinical efficacy

Towards a contextual response to peer-on-peer abuse : research and resources from MsUnderstood local site work 2013-2016

In 2013 the University of Bedfordshire, Imkaan and the Girls against Gangs Project formed the MsUnderstood Partnership (MSU) to support the development of responses to peer-on-peer abuse specifically, and young people’s experiences of inequality, more broadly. The partnership sought to bring academic rigour, partnerships with practitioners and young people’s voices to the fore of the debate, and generate practice-based evidence to support the development of responses that engaged with young people’s lived realities of violence and abuse. We achieved this through: • A programme of work with local multi-agency partnerships to audit and develop their responses to peer-on-peer abuse (Local Site Work) • A paid internship and young people’s engagement programme • Engagement in policy consultation and influencing • The dissemination of research, practice learning and young people’s voice This report chronicles the findings and resources generated by MSU over the past three years, with specific reference to the tools and knowledge created alongside professionals through local site work

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism.

Fucosyltransferase 2 (FUT2) is an enzyme that is responsible for the synthesis of the H antigen in body fluids and on the intestinal mucosa. The H antigen is an oligosaccharide moiety that acts as both an attachment site and carbon source for intestinal bacteria. Non-secretors, who are homozygous for the loss-of-function alleles of FUT2 gene (sese), have increased susceptibility to Crohn's disease (CD). To characterize the effect of FUT2 polymorphism on the mucosal ecosystem, we profiled the microbiome, meta-proteome and meta-metabolome of 75 endoscopic lavage samples from the cecum and sigmoid of 39 healthy subjects (12 SeSe, 18 Sese and 9 sese). Imputed metagenomic analysis revealed perturbations of energy metabolism in the microbiome of non-secretor and heterozygote individuals, notably the enrichment of carbohydrate and lipid metabolism, cofactor and vitamin metabolism and glycan biosynthesis and metabolism-related pathways, and the depletion of amino-acid biosynthesis and metabolism. Similar changes were observed in mice bearing the FUT2(-/-) genotype. Metabolomic analysis of human specimens revealed concordant as well as novel changes in the levels of several metabolites. Human metaproteomic analysis indicated that these functional changes were accompanied by sub-clinical levels of inflammation in the local intestinal mucosa. Therefore, the colonic microbiota of non-secretors is altered at both the compositional and functional levels, affecting the host mucosal state and potentially explaining the association of FUT2 genotype and CD susceptibility

Interplay of Inflammatory, Antigen and Tissue-Derived Signals in the Development of Resident CD8 Memory T Cells

CD8 positive, tissue resident memory T cells (TRM) are a specialized subset of CD8 memory T cells that surveil tissues and provide critical first-line protection against tumors and pathogen re-infection. Recently, much effort has been dedicated to understanding the function, phenotype and development of TRM. A myriad of signals is involved in the development and maintenance of resident memory T cells in tissue. Much of the initial research focused on the roles tissue-derived signals play in the development of TRM, including TGFß and IL-33 which are critical for the upregulation of CD69 and CD103. However, more recent data suggest further roles for antigenic and pro-inflammatory cytokines. This review will focus on the interplay of pro-inflammatory, tissue and antigenic signals in the establishment of resident memory T cells

Prospectus, November 2, 1988

https://spark.parkland.edu/prospectus_1988/1027/thumbnail.jp

NIR Spectroscopy of Star-Forming Galaxies at z~1.4 with Subaru/FMOS: The Mass-Metallicity Relation

We present near-infrared spectroscopic observations of star-forming galaxies at z~1.4 with FMOS on the Subaru Telescope. We observed K-band selected galaxies in the SXDS/UDS fields with K10^{9.5} Msun, and expected F(Halpha)>10^{-16} erg s^{-1} cm^{-2}. 71 objects in the sample have significant detections of Halpha. For these objects, excluding possible AGNs identified from the BPT diagram, gas-phase metallicities are obtained from [NII]/Halpha line ratio. The sample is split into three stellar mass bins, and the spectra are stacked in each stellar mass bin. The mass-metallicity relation obtained at z~1.4 is located between those at z~0.8 and z~2.2. We constrain an intrinsic scatter to be ~0.1 dex or larger in the mass-metallicity relation at z~1.4; the scatter may be larger at higher redshifts. We found trends that the deviation from the mass-metallicity relation depends on the SFR and the half light radius: Galaxies with higher SFR and larger half light radii show lower metallicities at a given stellar mass. One possible scenario for the trends is the infall of pristine gas accreted from IGM or through merger events. Our data points show larger scatter than the fundamental metallicity relation (FMR) at z~0.1 and the average metallicities slightly deviate from the FMR. The compilation of the mass-metallicity relations at z~3 to z~0.1 shows that they evolve smoothly from z~3 to z~0 without changing the shape so much except for the massive part at z~0.Comment: 20 pages, 18 figures, accepted for publication in PAS