A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

An Adipocitolitic Aqueous Micro-Gelatinous Solution for Buffalo Hump Deformity Reduction

Buffalo hump is a manifestation of HIV related lipodistrophy, it is characterized by an enlargment of dorsocervical fat pad and is distressing for patients. Surgical correction until a few years ago was the only option for treatment, however in last years non surgical corrections was carried out with minimally invasive techniques. Authors report this case that describe a longer follow up of an already published study were this deformity was treated with the injection of an adipocitolitic aqueous micro-gelatinous solution and during all the follow up no relapse was observed

Comparison Between Lipofilling and a Nonabsorbable Filler for Facial Wasting Rehabilitation in HIV-Positive Patients

Background: Several treatments have been described for facial wasting rehabilitation in HIV-positive patients. In this article, we compare lipofilling and a nonabsorbable filler for facial wasting rehabilitation induced by antiretroviral therapy in HIV-positive patients. Methods: This study was conducted as a clinical prospective study. Twenty-three HIV-positive patients affected by facial wasting were treated for facial rehabilitation, between January 2007 and December 2008, at the Head and Neck Department of the II University of Naples. They were divided into 2 groups; the first group was treated with lipofilling (group A), and the second one with the injection of a nonabsorbable filler, Aquamid reconstruction (Contura International A/S, Soeborg, Denmark) (group B). All the patients were HIV-positive, they had been receiving antiretroviral therapy for several years (1.8-6.7 years, 3.2 years on average) and showed clinical signs of facial lipoatrophy. Group A was composed of 14 patients (9 men, 5 women; mean age, 43.7 years), all presenting facial wasting and lipohypertrophied areas of the body. Group B was composed of 9 male patients, 7 presenting only facial wasting, and 2 presenting lipohypertrophied areas of the body (mean age, 44.8 years). Clinical efficacy was assessed independently by the investigator and the patient, 3 months, 6 months, and 1 year after baseline. The main assessment was made by the investigator using the Global Aesthetic Improvement Scale (GAIS) 1 year after baseline; secondary assessment using the GAIS was made by the investigator and the patient 6 months after baseline. Results: There were no major complications. No infections or other complications were observed. According to GAIS ratings, group A (lipofilling) obtained significantly higher ratings than did group B (nonabsorbable filler) after baseline (P < 0.05). Conclusions: We can treat HIV-related lipodistrophy more extensively with lipofilling because, after harvesting the fat graft, other body contouring procedures also can be performed; there is a better aesthetic outcome in facial rehabilitation performed with lipofilling, probably due to the possibility to fill deeper than with nonabsorbable fillers

A modified alar cinch suture technique

Widening of the alar base following total maxillary osteotomy is a well-known phenomenon. This change in the nasal morphology can compromise the facial aesthetics of the patient. Alar cinching through the vestibular incision used for maxillary osteotomy appears to be a simple and convenient means to narrow the alar base. We present a modified alar base cinch suturing technique and compare it with the published techniques in the literature. © 2009 Springer-Verlag

Application of Synthetic Lip Motion to Hybrid Video Coding

Video transmission over PSTN links (Public Switched Telephone Networks) suffers from strong bandwidth constraints limiting both the image size and the frame rate, even when efficient coding is adopted. Furthermore there is a lack of audio-video synchronization due to the non-constant frame rate. To overcome these limitations, a method has been devised that extrapolates synthetic frames from the real ones by means of speech analysis and mouth articulatory estimation to predict the motion of the synthetic. An optimized texture mapping technique has been applied to paste this new synthetic information over the last real frame decoded. Only the reproduction of the mouth motion can be improved with this kind of algorithms, while other regions of the image remain, evidently unchanged. A complete compatibility with any video-phone standard is achieved since this method involves only post-processing of the received data

Synthesis and Aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones.

Abstract—Several (Z)-5-arylidene-2,4-thiazolidinediones were synthesized and tested as aldose reductase inhibitors (ARIs). Themost active of the N-unsubstituted derivatives (2) exerted the same inhibitory activity of Sorbinil. The introduction of an acetic sidechain on N-3of the thiazolidinedione moiety led to a marked increase in lending inhibitory activity, conducting to the discovery ofa very potent ARI (4c), whose activity level (IC50=0.13 mM) was in the same range of Tolrestat. Moreover, the correspondingmethyl esters (3), devoid of any acidic functionality, showed appreciable inhibitory activity similar to that of the N-unsubstitutedcompounds. It was also found that the substitution pattern on the 5-benzylidene moiety markedly influenced the activity of Nunsubstituted2,4-thiazolidinediones 2, compounds with substituents at the meta position being generally more effective than thepara-substituted ones; however, this SAR was not evidenced in acetates 3 and acids 4

Smooth Muscle Cell Phenotypic Transition Associated With Calcification: Upregulation of Cbfa1 and Downregulation of Smooth Muscle Lineage Markers

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