18 research outputs found
Identification of Reproduction-Specific Genes Associated with Maturation and Estrogen Exposure in a Marine Bivalve Mytilus edulis
Get PDFBackground: While it is established that vertebrate-like steroids, particularly estrogens (estradiol, estrone) and androgens (testosterone), are present in various tissues of molluscs, it is still unclear what role these play in reproductive endocrinology in such organisms. This is despite the significant commercial shellfishery interest in several bivalve species and their decline. Methodology/Principal Findings: Using suppression subtraction hybridisation of mussel gonad samples at two stages (early and mature) of gametogenesis and (in parallel) following controlled laboratory estrogen exposure, we isolate several differentially regulated genes including testis-specific kinases, vitelline lysin and envelope sequences. Conclusions: The differentially expressed mRNAs isolated provide evidence that mussels may be impacted by exogenous estrogen exposure
Developing for other cultures. A Cultural Model for Learning Tools Design in the Nasa (Paez) Amerindian Context
No full textISBN : 142006945
Identification of Adducts Formed in Reactions of 2‘-Deoxyadenosine and Calf Thymus DNA with the Bacterial Mutagen 3-Chloro-4-(chloromethyl)-5-hydroxy-2(5 H
No full textIdentification of Conjugate Adducts Formed in the Reactions of Malonaldehyde-Acetaldehyde and Malonaldehyde-Formaldehyde with Cytidine
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Identification of an Ethenoformyl Adduct Formed in the Reaction of the Potent Bacterial Mutagen 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5 H
No full textCytotoxic and genotoxic effects of sodium hypochlorite on human peripheral lymphocytes in vitro
No full textChlorination is widely used method in the disinfection of drinking and utility water worldwide. In this study, cytotoxic and genotoxic effects of sodium hypochlorite were investigated by the cytokinesis-block micronucleus assay and chromosomal aberration analysis on human peripheral lymphocytes in vitro. A significant increase in chromosomal aberration frequency was observed in all treatments of NaOCl (0.030, 0.065, 0.100, 0.25, 0.5, 1, 2, 4 μg/mL) at 24 and 48 h compared with the negative control and mitomycin C (MMC, 0.3 μg/mL), which was used as a positive control. NaOCl significantly increased the frequency of micronuclei in a dose dependent manner. The results showed that there was a significant correlation between NaOCl concentration and chromosomal aberration, micronuclei frequency, necrotic cells, apoptotic cells and binucleated cells
Formation of Epichlorohydrin, a Known Rodent Carcinogen, Following Oral Administration of 1,3-Dichloro-2-propanol in Rats
No full textSynthesis and Properties of an Acetaldehyde-Derived Oligonucleotide Interstrand Cross-Link
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