Kalman Filter Equalization For QPSK Communications

The discrete complex Kalman filter is considered as an equalizer for quadrature phase-shift keyed (QPSK) systems in the presence of additive noise and InterSymbol interference (ISI). When the channel is unknown, an adaptive Kalman equalizer is used in which the channel complex tap gains are estimated by decision feedback. Copyright © 1976 by The Institute of Electrical and Electronics Engineers, Inc

Early Hepatocellular Carcinoma: Transplantation versus Resection: The Case for Liver Resection

The optimal surgical treatment of hepatocellular carcinoma on well-compensated cirrhosis is controversial. Advocates of liver transplantation cite better long-term survival, lower risk of recurrence, and the ability of transplantation to treat both the HCC and the underlying liver cirrhosis. Transplantation, however, is not universally available to all appropriate-risk candidates because of a lack of sufficient organ donors and in addition suffers from the disadvantages of requiring a more complex pre- and postoperative management associated with risks of inaccessibility, noncompliance, and late complications. Resection, by contrast, is much more easily and widely available, avoids many of those risks, is by many accounts as effective at achieving similar long-term survival, and still allows for safe, subsequent liver transplantation in cases of recurrence. Here, arguments are made in favor of resection being easier, safer, simpler, and comparably effective in the treatment of HCC relative to transplantation, and therefore being the optimal initial treatment in cases of hepatocellular carcinoma on well-compensated cirrhosis

No evidence for feedback: Unexceptional Low-ionization winds in Host galaxies of Low Luminosity Active Galactic Nuclei at Redshift z ~1

We study winds in 12 X-ray AGN host galaxies at z ~ 1. We find, using the low-ionization Fe II 2586 absorption in the stacked spectra, that the probability distribution function (PDF) of the centroid velocity shift in AGN has a median, 16th and 84th percentiles of (-87, -251, +86) km/s respectively. The PDF of the velocity dispersion in AGN has a median, 84th and 16th percentile of (139, 253, 52) km/s respectively. The centroid velocity and the velocity dispersions are obtained from a two component (ISM+wind) absorption line model. The equivalent width PDF of the outflow in AGN has median, 84th and 16th percentiles of (0.4, 0.8, 0.1) Angstrom. There is a strong ISM component in Fe II 2586 absorption with (1.2, 1.5, 0.8) Angstrom, implying presence of substantial amount cold gas in the host galaxies. For comparison, star-forming and X-ray undetected galaxies at a similar redshift, matched roughly in stellar mass and galaxy inclination, have a centroid velocity PDF with percentiles of (-74, -258, +90) km/s, and a velocity dispersion PDF percentiles of (150, 259, 57) km/s. Thus, winds in the AGN are similar to star-formation-driven winds, and are too weak to escape and expel substantial cool gas from galaxies. Our sample doubles the previous sample of AGN studied at z ~ 0.5 and extends the analysis to z ~ 1. A joint reanalysis of the z ~ 0.5 AGN sample and our sample yields consistent results to the measurements above.Comment: 24 pages, 11 figures, accepted in Ap

Household Livelihoods, Marketing And Resource Impacts: A Case Study Of Bark Products In Eastern Zimbabwe

An IES Working Paper.The bark of Warburgia salutaris, locally known as muranga, is a medicine of great traditional significance in Zimbabwe. However, trees of this species are at or near extinction in the wild in Zimbabwe. In this paper, the economics of the re-introduction of this rare medicinal species in some relatively moist, high altitude sites in south-eastern Zimbabwe are examined. The analysis builds on the information base provided by a recent pilot project of Warburgia re-introduction, as well as on market price data from a survey of current medicinal bark markets and on assumptions regarding the prospective future production and use of Warburgia leaves and bark by farmers and healers. The economic analysis, strongly suggests that expanded Warburgia production, at least on a small scale, in the remote, hilly region of southeastern Zimbabwe is very economically attractive and conducive to improving rural incomes and livelihoods of small-holders. This conclusion holds true in private feasibility terms, for both small-scale farmers and healer-growers, and in terms of social cost benefit analysis wherein seedling subsidies are removed.Funding for the study was provided by Canadian International Development Agency (CIDA) through the Agro-forestry Southern Africa project and the World Wide Fund for Nature (WWF) People and Plants Initiative

Online interventions for problem gamblers with and without co-occurring mental health symptoms: protocol for a randomized controlled trial

BACKGROUND Comorbidity between problem gambling and depression or anxiety is common. Further, the treatment needs of people with co-occurring gambling and mental health symptoms may be different from those of problem gamblers who do not have a co-occurring mental health concern. The current randomized controlled trial (RCT) will evaluate whether there is a benefit to providing access to mental health Internet interventions (G + MH intervention) in addition to an Internet intervention for problem gambling (G-only intervention) in participants with gambling problems who do or do not have co-occurring mental health symptoms. METHODS Potential participants will be screened using an online survey to identify participants meeting criteria for problem gambling. As part of the baseline screening process, measures of current depression and anxiety will be assessed. Eligible participants agreeing (N = 280) to take part in the study will be randomized to one of two versions of an online intervention for gamblers – an intervention that just targets gambling issues (G-only) versus a website that contains interventions for depression and anxiety in addition to an intervention for gamblers (G + MH). It is predicted that problem gamblers who do not have co-occurring mental health symptoms will display no significant difference between intervention conditions at a six-month follow-up. However, for those with co-occurring mental health symptoms, it is predicted that participants receiving access to the G + MH website will display significantly reduced gambling outcomes at six-month follow-up as compared to those provided with G-only website. DISCUSSION The trial will produce information on the best means of providing online help to gamblers with and without co-occurring mental health symptoms.This research was funded by the Manitoba Gambling Research Program of Manitoba Liquor and Lotteries

Species Traits Predict Assemblage Dynamics at Ephemeral Resource Patches Created by Carrion

Carrion is an ephemeral and spatially patchy resource that supports a diverse subset of species linked to nutrient cycling and the decomposition process. A number of studies have separately documented changes in the diversity of plants, arthropods and vertebrates at individual carcasses, but there are few studies that have examined how functional traits of different groups of organisms underpin their responses to carrion patches. We used a carrion addition experiment to compare changes in composition and functional traits of insect and plant assemblages at carcasses compared with control sites. We found that significant changes in insect assemblage evenness and heterogeneity was associated with species' dispersal traits, and that plant assemblage responses to subsequent soil nitrogen changes was most apparent among graminoids and exotic species. Beetles at carcasses were twice as large as their counterparts at control sites during the first week of carrion decomposition, and also had higher wing loadings. Plants with high specific leaf area responded faster to the carcass addition, and twice as many species recolonised the centre of carcasses in exotic-dominated grassland compared with carcasses in native-dominated grassland. These results provide an example of how traits of opportunist species enable them to exploit patchy and dynamic resources. This increases our understanding of how carcasses can drive biodiversity dynamics, and has implications for the way carrion might be managed in ecosystems, such as appropriate consideration of spatial and temporal continuity in carrion resources to promote heterogeneity in nutrient cycling and species diversity within landscapes.This research was supported by the Mulligans Flat – Goorooyarroo Woodland Experiment (Australian Research Council Linkage Grants LP0561817 and LP110100126). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics.

Synthetic protein switches controlled with user-defined inputs are powerful tools for studying and controlling dynamic cellular processes. To date, these approaches have relied primarily on intermolecular regulation. Here we report a computationally guided framework for engineering intramolecular regulation of protein function. We utilize this framework to develop chemically inducible activator of RAS (CIAR), a single-component RAS rheostat that directly activates endogenous RAS in response to a small molecule. Using CIAR, we show that direct RAS activation elicits markedly different RAS-ERK signaling dynamics from growth factor stimulation, and that these dynamics differ among cell types. We also found that the clinically approved RAF inhibitor vemurafenib potently primes cells to respond to direct wild-type RAS activation. These results demonstrate the utility of CIAR for quantitatively interrogating RAS signaling. Finally, we demonstrate the general utility of our approach in design of intramolecularly regulated protein tools by applying it to the Rho family of guanine nucleotide exchange factors

Reliability and Validity of Ultrasound Cross Sectional Area Measurements for Long-Duration Spaceflight

Limb muscle atrophy and the accompanying decline in function can adversely affect the performance of astronauts during mission-related activities and upon re-ambulation in a gravitational environment. Previous characterization of space flight-induced muscle atrophy has been performed using pre and post flight magnetic resonance imaging (MRI). In addition to being costly and time consuming, MRI is an impractical methodology for assessing in-flight changes in muscle size. Given the mobility of ultrasound (US) equipment, it may be more feasible to evaluate changes in muscle size using this technique. PURPOSE: To examine the reliability and validity of using a customized template to acquire panoramic ultrasound (US) images for determining quadriceps and gastrocnemius anatomical cross sectional area (CSA). METHODS: Vastus lateralis (VL), rectus femoris (RF), medial gastrocnemius (MG), and lateral gastrocnemius (LG) CSA were assessed in 10 healthy individuals (36+/-2 yrs) using US and MRI. Panoramic US images were acquired by 2 sonographers using a customized template placed on the thigh and calf and analyzed by the same 2 sonographers (CX50 Philips). MRI images of the leg were acquired while subjects were supine in a 1.5T scanner (Signa Horizon LX, General Electric) and were analyzed by 3 trained investigators. The average of the 2 US and 3 MRI values were used for validity analysis. RESULTS: High inter-experimenter reliability was found for both the US template and MRI analysis as coefficients of variation across muscles ranged from 2.4 to 4.1% and 2.8 to 3.8%, respectively. Significant correlations were found between US and MRI CSA measures (VL, r = 0.85; RF, r = 0.60; MG, r = 0.86; LG, r = 0.73; p < 0.05). Furthermore, the standard error of measurement between US and MRI ranged from 0.91 to 2.09 sq cm with high limits of agreement analyzed by Bland-Altman plots. However, there were significant differences between absolute values of MRI and US for all muscles. CONCLUSION: The present results indicate that utilizing a customized US template provides reliable measures of leg muscle CSA, and thus could be used to characterize changes in muscle CSA both in flight and on the ground

The power of co-ordinate transformations in dynamical interpretations of Galactic structure

$Gaia$ DR2 has provided an unprecedented wealth of information about the positions and motions of stars in our Galaxy, and has highlighted the degree of disequilibria in the disc. As we collect data over a wider area of the disc it becomes increasingly appealing to start analysing stellar actions and angles, which specifically label orbit space, instead of their current phase space location. Conceptually, while $\bar{x}$ and $\bar{v}$ tell us about the potential and local interactions, grouping in action puts together stars that have similar frequencies and hence similar responses to dynamical effects occurring over several orbits. Grouping in actions and angles refines this further to isolate stars which are travelling together through space and hence have shared histories. Mixing these coordinate systems can confuse the interpretation. For example, it has been suggested that by moving stars to their guiding radius, the Milky Way spiral structure is visible as ridge-like overdensities in the $Gaia$ data \citep{Khoperskov+19b}. However, in this work, we show that these features are in fact the known kinematic moving groups, both in the $L_z-\phi$ and the $v_{\mathrm{R}}-v_{\phi}$ planes. Using simulations we show how this distinction will become even more important as we move to a global view of the Milky Way. As an example, we show that the radial velocity wave seen in the Galactic disc in $Gaia$ and APOGEE should become stronger in the action-angle frame, and that it can be reproduced by transient spiral structure.Comment: 12 pages, 10 Figure

The value of source data verification in a cancer clinical trial

Background Source data verification (SDV) is a resource intensive method of quality assurance frequently used in clinical trials. There is no empirical evidence to suggest that SDV would impact on comparative treatment effect results from a clinical trial. Methods Data discrepancies and comparative treatment effects obtained following 100% SDV were compared to those based on data without SDV. Overall survival (OS) and Progression-free survival (PFS) were compared using Kaplan-Meier curves, log-rank tests and Cox models. Tumour response classifications and comparative treatment Odds Ratios (ORs) for the outcome objective response rate, and number of Serious Adverse Events (SAEs) were compared. OS estimates based on SDV data were compared against estimates obtained from centrally monitored data. Findings Data discrepancies were identified between different monitoring procedures for the majority of variables examined, with some variation in discrepancy rates. There were no systematic patterns to discrepancies and their impact was negligible on OS, the primary outcome of the trial (HR (95% CI): 1.18(0.99 to 1.41), p = 0.064 with 100% SDV; 1.18(0.99 to 1.42), p = 0.068 without SDV; 1.18(0.99 to 1.40), p = 0.073 with central monitoring). Results were similar for PFS. More extreme discrepancies were found for the subjective outcome overall objective response (OR (95% CI): 1.67(1.04 to 2.68), p = 0.03 with 100% SDV; 2.45(1.49 to 4.04), p = 0.0003 without any SDV) which was mostly due to differing CT scans. Interpretation Quality assurance methods used in clinical trials should be informed by empirical evidence. In this empirical comparison, SDV was expensive and identified random errors that made little impact on results and clinical conclusions of the trial. Central monitoring using an external data source was a more efficient approach for the primary outcome of OS. For the subjective outcome objective response, an independent blinded review committee and tracking system to monitor missing scan data could be more efficient than SDV