442 research outputs found
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Eleutherodactylus chlorophenax
Number of Pages: 2Integrative BiologyGeological Science
Crisis, pandemic, and beyond : nonprofits and the adaptive capability of communities
Publisher PDFNon peer reviewe
Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1Ī² and IL-6
<p>Abstract</p> <p>Background</p> <p>Chronic neurodegeneration comprises an inflammatory response but its contribution to the progression of disease remains unclear. We have previously shown that microglial cells are primed by chronic neurodegeneration, induced by the ME7 strain of prion disease, to synthesize limited pro-inflammatory cytokines but to produce exaggerated responses to subsequent systemic inflammatory insults. The consequences of this primed response include exaggerated hypothermic and sickness behavioural responses, acute neuronal death and accelerated progression of disease. Here we investigated whether inhibition of systemic cytokine synthesis using the anti-inflammatory steroid dexamethasone-21-phosphate was sufficient to block any or all of these responses.</p> <p>Methods</p> <p>ME7 animals, at 18-19 weeks post-inoculation, were challenged with LPS (500 Ī¼g/kg) in the presence or absence of dexamethasone-21-phosphate (2 mg/kg) and effects on core-body temperature and systemic and CNS cytokine production and apoptosis were examined.</p> <p>Results</p> <p>LPS induced hypothermia and decreased exploratory activity. Dexamethasone-21-phosphate prevented this hypothermia, markedly suppressed systemic IL-1Ī² and IL-6 secretion but did not prevent decreased exploration. Furthermore, robust transcription of cytokine mRNA occurred in the hippocampus of both ME7 and NBH (normal brain homogenate) control animals despite the effective blocking of systemic cytokine synthesis. Microglia primed by neurodegeneration were not blocked from the robust synthesis of IL-1Ī² protein and endothelial COX-2 was also robustly synthesized. We injected biotinylated LPS at 100 Ī¼g/kg and even at this lower dose this could be detected in blood plasma. Apoptosis was acutely induced by LPS, despite the inhibition of the systemic cytokine response.</p> <p>Conclusions</p> <p>These data suggest that LPS can directly activate the brain endothelium even at relatively low doses, obviating the need for systemic cytokine stimulation to transduce systemic inflammatory signals into the brain or to exacerbate existing pathology.</p
Who benefits and how? Public expectations of public benefits from data-intensive health research
The digitization of society and academic research endeavours have led to an explosion of interest in the potential uses of population data in research. Alongside this, increasing attention is focussing on the conditions necessary for maintaining a social license for research practices. Previous research has pointed to the importance of demonstrating āpublic benefitsā from research for maintaining public support, yet there has been very little consideration of what the term āpublic benefitsā means or what public expectations of āpublic benefitsā are. In order to address this pressing issue a series of deliberative workshops with members of the public were held across Scotland in May and June 2017. The workshops aimed to engage a cross-section of the Scottish population in in-depth discussions of the ways that the public ā or publics ā might benefit from data-intensive health research. The findings reported here discuss workshop participantsā understandings and expectations of health research; who they considered to be āthe publicā that should benefit from health research and; in what ways they felt āthe publicā should benefit. Workshop participantsā preference was clearly for the widest possible public benefit to be felt by all, but they also acknowledged the value in research aiming to primarily benefit vulnerable groups within society. A key focus of discussions was the extent to which workshop participants were confident that potential public benefits would be realised. A crucial consideration then is the extent to which mechanisms and political support are in place to realise and maximise the public benefits of data-intensive health research
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Association of cognition with functional trajectories in patients admitted to geriatric wards: A retrospective observational study.
AIM: Impaired cognition is common among older patients admitted to acute hospitals, but its association with functional trajectories has not been well studied. METHODS: A retrospective observational study was carried out in an English tertiary university hospital. We analyzed all first episodes of county residents aged ā„75āyears admitted to the Department of Medicine for the Elderly wards between December 2014 and May 2015. A history of dementia or a cognitive concern in the absence of a known diagnosis of dementia were recorded on admission. A cognitive concern included possible undiagnosed dementia or delirium. Function was retrospectively measured with the modified Rankin Scale at preadmission baseline, admission and discharge. RESULTS: There were 663 first hospital episodes over the period, of which 590 patients survived. Among the latter, 244 had no cognitive impairment, 134 a diagnosis of dementia, 66 a cognitive concern in the absence of a known dementia and 146 had missing cognitive data. When frailty, acuity, age and comorbidity were controlled for, people with known dementia had a similar functional recovery compared with those with no cognitive impairment. People with a cognitive concern, but no known dementia, had lesser functional recovery and greater disability at discharge than those with no cognitive impairment (mean discharge modified Rankin Scale 3.4 compared with 3.1, Pā=ā0.011). CONCLUSIONS: Dementia per se might not be a marker of poor rehabilitation potential. Older people with acute cognitive concerns might be more vulnerable to poor functional recovery. Our cognitive variables are not gold standard, and further research is required to clarify this relationship. Geriatr Gerontol Int 2017; 17: 1438-1443.This is the author accepted manuscript. The final version is available from Wiley via https://doi.org/10.1111/ggi.1288
Jamaican Universities Aiding the Design of an Urban Public Space
Many governments are actively seeking solutions to address the economic crises bedeviling their countries. University/college towns have proven to be successful models of opportunities for attracting investments for economic development while at the same time promoting optimal health outcomes. Harvard, MIT and Newcastle universities provide examples of successful models of universities aiding in spatial design and planning of towns or neighborhoods where they are located to yield sustainable development. The Government of Jamaica has supported the proposal from the University of Technology, Jamaica, (UTech, Jamaica Ja.) to redesign the Papine area in St. Andrew into a university town, given its proximity to the two largest universities in Jamaica, UTech, Ja. and the University of the West Indies (UWI). Both institutions collaborated by using cutting-edge scholarly research and design approaches to propose workable solutions that can promote economic development and healthy lifestyle in an area designated as a university town. The research found that SOPARC was a feasible and reliable instrument for assessing park user variables and associated contextual variables. However, for the proposed design to be executed and maintained, the study recommends establishing a body such as a University District/Town Council with oversight responsibility for planning and land use management of the area
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