Dynamic acoustic field activated cell separation (DAFACS)

Advances in diagnostics, cell and stem cell technologies drive the development of application-specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for highthroughput, label-free, high recovery, cell and particle separation and isolation in regenerative medicine. Here, we demonstrate a novel approach utilizing a dynamic acoustic field that is capable of separating an arbitrary size range of cells. We first demonstrate the method for the separation of particles with different diameters between 6 and 45 μm and secondly particles of different densities in a heterogeneous medium. The dynamic acoustic field is then used to separate dorsal root ganglion cells. The shearless, label-free and low damage characteristics make this method of manipulation particularly suited for biological applications. Advantages of using a dynamic acoustic field for the separation of cells include its inherent safety and biocompatibility, the possibility to operate over large distances (centimetres), high purity (ratio of particle population, up to 100%), and high efficiency (ratio of separated particles over total number of particles to separate, up to 100%)

A change in the quiescent X-ray spectrum of the neutron star low-mass X-ray binary MXB 1659-29

The quasi-persistent neutron star low-mass X-ray binary MXB 1659-29 went into quiescence in 2001, and we have followed its quiescent X-ray evolution since. Observations over the first 4 years showed a rapid drop in flux and temperature of the neutron star atmosphere, interpreted as cooling of the neutron star crust which had been heated during the 2.5 year outburst. However, observations taken approximately 1400 and 2400 days into quiescence were consistent with each other, suggesting the crust had reached thermal equilibrium with the core. Here we present a new Chandra observation of MXB 1659-29 taken 11 years into quiescence and 4 years since the last Chandra observation. This new observation shows an unexpected factor of ~3 drop in count rate and change in spectral shape since the last observation, which cannot be explained simply by continued cooling. Two possible scenarios are that either the neutron star temperature has remained unchanged and there has been an increase in the column density, or, alternatively the neutron star temperature has dropped precipitously and the spectrum is now dominated by a power-law component. The first scenario may be possible given that MXB 1659-29 is a near edge-on system, and an increase in column density could be due to build-up of material in, and a thickening of, a truncated accretion disk during quiescence. But, a large change in disk height may not be plausible if standard accretion disk theory holds during quiescence. Alternatively, the disk may be precessing, leading to a higher column density during this latest observation.Comment: 6 pages, 4 figures, accepted for publication in Ap

Dust around Type Ia supernovae

An explanation is given of the low value of $R_\lambda \equiv A_\lambda/E(B-V)$, the ratio of absolute to selective extinction deduced from Type Ia supernova observations. The idea involves scattering by dust clouds located in the circumstellar environment, or at the highest velocity shells of the supernova ejecta. The scattered light tends to reduce the effective $R_\lambda$ in the optical, but has an opposite effect in the ultraviolet. The presence of circumstellar dust can be tested by ultraviolet to near infrared observations and by multi-epoch spectropolarimetry of SNe Ia.Comment: ApJL, in pres

Relinquishing Control: What Romanian De Se Attitude Reports Teach Us About Immunity To Error Through Misidentification

Higginbotham argued that certain linguistic items of English, when used in indirect discourse, necessarily trigger first-personal interpretations. They are: the emphatic reflexive pronoun and the controlled understood subject, represented as PRO. PRO is special, in this respect, due to its imposing obligatory control effects between the main clause and its subordinates ). Folescu & Higginbotham, in addition, argued that in Romanian, a language whose grammar doesn’t assign a prominent role to PRO, de se triggers are correlated with the subjunctive mood of certain verbs. That paper, however, didn’t account for the grammatical diversity of the reports that display immunity to error through misidentification in Romanian: some of these reports are expressed by using de se triggers; others are not. Their IEM, moreover, is not systematically lexically controlled by the verbs, via their theta-roles; it is, rather, determined by the meaning of the verbs in question. Given the data from Romanian, I will argue, the phenomenon of IEM cannot be fully explained starting either from the syntactical or the lexical structure of a language

Probing the Crust of the Neutron Star in EXO 0748-676

X-ray observations of quiescent X-ray binaries have the potential to provide insight into the structure and the composition of neutron stars. EXO 0748-676 had been actively accreting for over 24 yr before its outburst ceased in late 2008. Subsequent X-ray monitoring revealed a gradual decay of the quiescent thermal emission that can be attributed to cooling of the accretion-heated neutron star crust. In this work, we report on new Chandra and Swift observations that extend the quiescent monitoring to ~5 yr post-outburst. We find that the neutron star temperature remained at ~117 eV between 2009 and 2011, but had decreased to ~110 eV in 2013. This suggests that the crust has not fully cooled yet, which is supported by the lower temperature of ~95 eV that was measured ~4 yr prior to the accretion phase in 1980. Comparing the data to thermal evolution simulations reveals that the apparent lack of cooling between 2009 and 2011 could possibly be a signature of convection driven by phase separation of light and heavy nuclei in the outer layers of the neutron star.Comment: 9 pages, 4 tables, 3 figures. Minor revisions according to referee report. Accepted to Ap

Mitigation of Moral Hazard and Adverse Selection in Venture Capital Financing: The Influence of the Country’s Institutional Setting

A venture capitalist (VC) needs to trade off benefits and costs when attempting to mitigate agency problems in their investor-investee relationship. We argue that signals of ventures complement the VC’s capacity to screen and conduct a due diligence during the pre-investment phase, but its attractiveness may diminish in institutional settings supporting greater transparency. Similarly, whereas a VC may opt for contractual covenants to curb potential opportunism by ventures in the post-investment phase, this may only be effective in settings supportive of shareholder rights enforcement. Using an international sample of VC contracts, our study finds broad support for these conjectures. It delineates theoretical and practical implications for how investors can best deploy their capital in different institutional settings whilst nurturing their relationships with entrepreneurs

INTEGRAL monitoring of unusually long X-ray bursts

X-ray bursts are thermonuclear explosions on the surface of accreting neutron stars in low mass X-ray binaries. As most of the known X-ray bursters are frequently observed by INTEGRAL, an international collaboration have been taking advantage of its instrumentation to specifically monitor the occurrence of exceptional burst events lasting more than ~10 minutes. Half of the so-called intermediate long bursts registered so far have been observed by INTEGRAL. The goal is to derive a comprehensive picture of the relationship between the nuclear ignition processes and the accretion states of the system leading up to such long bursts. Depending on the composition of the accreted material, these bursts may be explained by either the unstable burning of a large pile of mixed hydrogen and helium, or the ignition of a thick pure helium layer. Intermediate long bursts are particularly expected to occur at very low accretion rates and make possible to study the transition from a hydrogen-rich bursting regime to a pure helium regime.Comment: Talk presented at the 7th INTEGRAL Workshop, An INTEGRAL View of Compact Objects, Copenhagen, 8-11 September 2008. Submitted to Proceedings of Science. 12 pages, 6 figures, 2 tables, 40 reference

Photometry of SN 2002ic and Implications for the Progenitor Mass-Loss History

We present new pre-maximum and late-time optical photometry of the Type Ia/IIn supernova 2002ic. These observations are combined with the published V-band magnitudes of Hamuy et al. (2003) and the VLT spectrophotometry of Wang et al. (2004) to construct the most extensive light curve to date of this unusual supernova. The observed flux at late time is significantly higher relative to the flux at maximum than that of any other observed Type Ia supernova and continues to fade very slowly a year after explosion. Our analysis of the light curve suggests that a non-Type Ia supernova component becomes prominent $\sim20$ days after explosion. Modeling of the non-Type Ia supernova component as heating from the shock interaction of the supernova ejecta with pre-existing circumstellar material suggests the presence of a $\sim1.7 10^{15}$ cm gap or trough between the progenitor system and the surrounding circumstellar material. This gap could be due to significantly lower mass-loss $\sim15 (v_w/10 km/s)^{-1}$ years prior to explosion or evacuation of the circumstellar material by a low-density fast wind. The latter is consistent with observed properties of proto-planetary nebulae and with models of white-dwarf + asymptotic giant branch star progenitor systems with the asymptotic giant branch star in the proto-planetary nebula phase.Comment: accepted for publication in Ap

High time to enhance dancer welfare:a call to action to improve safeguarding and abuse prevention in dance

While there is a lack of research into abuse in elite dance, numerous allegations of emotional, sexual and physical abuse of dancers can be found anecdotally in the media, legal convictions and personal accounts. As more dancers speak out, the scale of the problem within preprofessional schools and professional companies is becoming apparent. Accordingly, effective safeguarding mechanisms for preventing, identifying and reporting abuse are urgently needed. This viewpoint is intended to raise health professionals' awareness of factors contributing to abusive practices found in dance environments and the potential clinical implications of abuse to dancers' health and well-being. We also call for research and policy engagement on safeguarding and abuse prevention designed and implemented in partnership with stakeholders, aiming to promote safe and positive dance environments for all.</p