Filamentation Instability of Interacting Current Sheets in Striped Relativistic Winds: The Origin of Low Sigma?

I outline a mechanism, akin to Weibel instabilities of interpenetrating beams, in which the neighboring current sheets in a striped wind from an oblique rotator interact through a two stream-like mechanism (a Weibel instability in flatland), to create an anomalous resistivity that heats the sheets and causes the magnetic field to diffusively annihilate in the wind upstream of the termination shock. The heating has consequences for observable unpulsed emission from pulsars.Comment: 7 pages, 9 figures. To be published in the proceedings of ``40 Years of Pulsars'

Bayes Linear Emulation of Simulated Crop Yield

The analysis of the output from a large-scale computer simulation experiment can pose a challenging problem in terms of size and computation. We consider output in the form of simulated crop yields from the Environmental Policy Integrated Climate (EPIC) model, which requires a large number of inputs—such as fertilizer levels, weather conditions, and crop rotations—inducing a high dimensional input space. In this paper, we adopt a Bayes linear approach to efficiently emulate crop yield as a function of the simulator fertilizer inputs. We explore emulator diagnostics and present the results from emulation of a subset of the simulated EPIC data output

Statistical Approach to Raman Analysis of Graphene-Related Materials: Implications for Quality Control

A statistical method to determine the number of measurements required from nanomaterials to ensure reliable and robust analysis is described. Commercial products utilizing graphene are in their infancy and recent investigations of commercial graphene manufacture have attributed this to the lack of robust metrology and standards by which graphene and related carbon materials can be measured and compared. Raman spectroscopy is known to be a useful tool in carbon nanomaterial characterization, but to provide meaningful information, in particular for quality control or management, multiple spectra are needed. Herein we present a statistical method to quantify the number of different spectra or other microscale measurements that should be taken to reliably characterize a graphene material. We have recorded a large number of Raman measurements and studied the statistical convergence of these data sets. We use a graphical approach to monitor the change in summary statistics and a Monte Carlo based bootstrapping method of data analysis to computationally resample the data demonstrating the effects of underanalyzing a material; for example, graphene nanoplatelets may require over 500 spectra before information about the exfoliation efficiency, particle size, layer number, and chemical functionalization is accurately obtained

An X-ray View of Radio Millisecond Pulsars

In recent years, X-ray observations with Chandra and XMM-Newton have significantly increased our understanding of rotation-powered (radio) millisecond pulsars (MSPs). Deep Chandra studies of several globular clusters have detected X-ray counterparts to a host of MSPs, including 19 in 47 Tuc alone. These surveys have revealed that most MSPs exhibit thermal emission from their heated magnetic polar caps. Realistic models of this thermal X-ray emission have provided important insight into the basic physics of pulsars and neutron stars. In addition, intrabinary shock X-ray radiation observed in ``black-widow'' and peculiar globular cluster ``exchanged'' binary MSPs give interesting insight into MSP winds and relativistic shock. Thus, the X-ray band contains valuable information regarding the basic properties of MSPs that are not accesible by radio timing observations.Comment: 5 pages, 5 figures, To appear in the proceedings of "40 Years of Pulsars: Millisecond Pulsars, Magnetars, and More", August 12-17, 2007, McGill University, Montreal, Canad

Bridging the Gap between Micro and Nanotechnology: Using Lab-on-a-Chip to enable Nanosensors for Genomics, Proteomics and Diagnostic Screening

Abstract. The growing need for accurate and fast methods of DNA and protein determination in the post human genome era has generated considerable interest in the development of new microfluidic analytical platforms, fabricated using methods adapted from the semi-conductor industry. These methods have resulted in the development of the Lab-on-a-Chip concept, a technology which often involves having a miniaturised biochip (as an analytical device), with rather larger instrumentation associated with the control of the associated sensors and of fluidics. This talk will explore the development of new Lab-ona-Chip platforms for DNA, protein and cell screening, using microfluidics as a packaging technology in order to enable advances in nanoscale science to be implemented in a Lab-on-a-Chip format. The talk will also show how system on a chip methods can be integrated with Lab-on-a-Chip devices to create remote and distributed intelligent sensors, which can be used in a variety of diagnostic applications, including for example chemical sensing within the GI tract

A novel series of positive modulators of the AMPA receptor : discovery and structure based hit-to-lead studies

Starting from an HTS derived hit 1, application of biostructural data facilitated rapid optimization to lead 22, a novel AMPA receptor modulator. This is the first demonstration of how structure based drug design can be exploited in an optimization program for a glutamate receptor

The need for establishing a universal CTG sizing method in myotonic dystrophy type 1

The number of cytosine-thymine-guanine (CTG) repeats (‘CTG expansion size’) in the 3′untranslated region (UTR) region of the dystrophia myotonica-protein kinase (DMPK) gene is a hallmark of myotonic dystrophy type 1 (DM1), which has been related to age of disease onset and clinical severity. However, accurate determination of CTG expansion size is challenging due to its characteristic instability. We compared five different approaches (heat pulse extension polymerase chain reaction [PCR], long PCR-Southern blot [with three different primers sets—1, 2 and 3] and small pool [SP]-PCR) to estimate CTG expansion size in the progenitor allele as well as the most abundant CTG expansion size, in 15 patients with DM1. Our results indicated variability between the methods (although we found no overall differences between long PCR 1 and 2 and SP-PCR, respectively). While keeping in mind the limited sample size of our patient cohort, SP-PCR appeared as the most suitable technique, with an inverse significant correlation found between CTG expansion size of the progenitor allele, as determined by this method, and age of disease onset (r = −0.734, p = 0.016). Yet, in light of the variability of the results obtained with the different methods, we propose that an international agreement is needed to determine which is the most suitable method for assessing CTG expansion size in DM1

The Anglo-Australian Planet Search XXIV: The Frequency of Jupiter Analogs

Robert A. Wittenmyer, et al, 'The Anglo-Australian planet search XXIV: The frequency of Jupiter analogs', The Astrophysical Journal, Vol. 819 (1), first published online 24 February 2016. The version of record is available online at doi: https://doi.org/10.3847/0004-637X/819/1/28 © 2016. The American Astronomical Society. All rights reserved.We present updated simulations of the detectability of Jupiter analogs by the 17-year Anglo-Australian Planet Search. The occurrence rate of Jupiter-like planets that have remained near their formation locations beyond the ice line is a critical datum necessary to constrain the details of planet formation. It is also vital in our quest to fully understand how common (or rare) planetary systems like our own are in the Galaxy. From a sample of 202 solar-type stars, and correcting for imperfect detectability on a star-by-star basis, we derive a frequency of ${6.2}_{-1.6}^{+2.8}$% for giant planets in orbits from 3 to 7 au. When a consistent definition of "Jupiter analog" is used, our results are in agreement with those from other legacy radial-velocity surveys.Peer reviewedFinal Published versio