41 research outputs found
Anisotropic charge dynamics in the quantum spin-liquid candidate -(BEDT-TTF)Cu(CN)
We have in detail characterized the anisotropic charge response of the dimer
Mott insulator -(BEDT-TTF)\-Cu(CN) by dc conductivity, Hall
effect and dielectric spectroscopy. At room temperature the Hall coefficient is
positive and close to the value expected from stoichiometry; the temperature
behavior follows the dc resistivity . Within the planes the dc
conductivity is well described by variable-range hopping in two dimensions;
this model, however, fails for the out-of-plane direction. An unusually broad
in-plane dielectric relaxation is detected below about 60 K; it slows down much
faster than the dc conductivity following an Arrhenius law. At around 17 K we
can identify a pronounced dielectric anomaly concomitantly with anomalous
features in the mean relaxation time and spectral broadening. The out-of-plane
relaxation, on the other hand, shows a much weaker dielectric anomaly; it
closely follows the temperature behavior of the respective dc resistivity. At
lower temperatures, the dielectric constant becomes smaller both within and
perpendicular to the planes; also the relaxation levels off. The observed
behavior bears features of relaxor-like ferroelectricity. Because
heterogeneities impede its long-range development, only a weak tunneling-like
dynamics persists at low temperatures. We suggest that the random potential and
domain structure gradually emerge due to the coupling to the anion network.Comment: 14 pages, 13 figure
Coexistence of orbital and quantum critical magnetoresistance in FeSeS
The recent discovery of a non-magnetic nematic quantum critical point (QCP)
in the iron chalcogenide family FeSeS has raised the prospect of
investigating, in isolation, the role of nematicity on the electronic
properties of correlated metals. Here we report a detailed study of the normal
state transverse magnetoresistance (MR) in FeSeS for a series of
S concentrations spanning the nematic QCP. For all temperatures and
\textit{x}-values studied, the MR can be decomposed into two distinct
components: one that varies quadratically in magnetic field strength
and one that follows precisely the quadrature scaling form
recently reported in metals at or close to a QCP and characterized by a
\textit{H}-linear MR over an extended field range. The two components evolve
systematically with both temperature and S-substitution in a manner that is
determined by their proximity to the nematic QCP. This study thus reveals
unambiguously the coexistence of two independent charge sectors in a quantum
critical system. Moreover, the quantum critical component of the MR is found to
be less sensitive to disorder than the quadratic (orbital) MR, suggesting that
detection of the latter in previous MR studies of metals near a QCP may have
been obscured.Comment: 19 pages (including Supplemental Material), 12 figure
Treatment of tumours with the combination of WR-2721 and cis-dichlorodiammineplatinum (II) or cyclophosphamide.
The ability of WR-2721 [S-2(3-aminopropylamino)ethyl-phosporothioic acid] to selectively protect the host against the toxic effects of multiple doses of cis-dichlorodiammineplatinum [cis-Pt] or cyclophosphamide [CY] has been studied in mice and rats bearing 3 different tumours. Selective protection against cis-Pt induced nephrotoxicity has been demonstrated under all conditions studied, with the extent of protection being inversely related to the size of the cis-Pt dose. For example, pre-treatment with 200 mg/kg of WR-2721 30 min before each weekly dose of 2 mg/kg of cis-Pt allows the administration of this cytotoxic agent for 3 times longer before nephrotoxic injury. In none of these studies was there tumour protection. The same pattern was observed with CY, but quantitation of the extent of marrow protection was not possible for the multiple treatment studies, due to the longer latent period between induced and observed death with this drug. We conclude, therefore, that for both of these drugs, selective protection of the kidney and marrow is not only maintained under conditions of multiple treatment, but actually enhanced due to the need for smaller doses of cytotoxic agents in these protocols
Incoherent transport across the strange metal regime of highly overdoped cuprates
Strange metals possess highly unconventional transport characteristics, such
as a linear-in-temperature () resistivity, an inverse Hall angle that varies
as and a linear-in-field () magnetoresistance. Identifying the origin
of these collective anomalies has proved profoundly challenging, even in
materials such as the hole-doped cuprates that possess a simple band structure.
The prevailing dogma is that strange metallicity in the cuprates is tied to a
quantum critical point at a doping inside the superconducting dome. Here,
we study the high-field in-plane magnetoresistance of two superconducting
cuprate families at doping levels beyond . At all dopings, the
magnetoresistance exhibits quadrature scaling and becomes linear at high
ratios. Moreover, its magnitude is found to be much larger than predicted by
conventional theory and insensitive to both impurity scattering and magnetic
field orientation. These observations, coupled with analysis of the zero-field
and Hall resistivities, suggest that despite having a single band, the cuprate
strange metal phase hosts two charge sectors, one containing coherent
quasiparticles, the other scale-invariant `Planckian' dissipators.Comment: 15 pages plus 7 figures (including Supplementary Information
Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study
Objectives. Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations.Methods. SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses.Results. The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP.AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001].Conclusion. Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality