A Schistosomiasis Model with Mating Structure

A schistosomiasis model is proposed including single schistosomes, paired schistosomes, snails, and the latent period of infected snails. A reasonable sex ratio of schistosomes and the minimum mating function are considered. A threshold condition determining the stability of the system is given, and the stability of equilibrium for the model is shown. The impact of the latent period of infected snails on schistosomiasis transmission can be found through numerical simulations. Finally, preferable control strategies are obtained by sensitivity analyses. Killing snails may be the preferred control measure. If we choose chemotherapy, we should use some drugs which are sufficient for reducing egg-associated pathology, since paired schistosomes are mostly harmful to definitive hosts

VLBI observations of a flared optical quasar CGRaBS J0809+5341

A bright optical flare was detected in the high-redshift ($z=2.133$) quasar CGRaBS J0809+5341 on 2014 April 13. The absolute magnitude of the object reached $-30.0$ during the flare, making it the brightest one (in flaring stage) among all known quasars so far. The 15 GHz flux density of CGRaBS J0809+5341 monitored in the period from 2008 to 2016 also reached its peak at the same time. To reveal any structural change possibly associated with the flare in the innermost radio structure of the quasar, we conducted a pilot very long baseline interferometry (VLBI) observation of CGRaBS J0809+5341 using the European VLBI Network (EVN) at 5 GHz on 2014 November 18, about seven months after the prominent optical flare. Three epochs of follow-up KaVA (Korean VLBI Network and VLBI Exploration of Radio Astrometry Array) observations were carried out at 22 and 43 GHz frequencies from 2015 February 25 to June 4, with the intention of exploring a possibly emerging new radio jet component associated with the optical flare. However, these high-resolution VLBI observations revealed only the milliarcsecond-scale compact "core" that was known in the quasar from earlier VLBI images, and showed no sign of any extended jet structure. Neither the size, nor the flux density of the "core" changed considerably after the flare according to our VLBI monitoring. The results suggest that any putative radio ejecta associated with the major optical and radio flare could not yet be separated from the "core" component, or the newly-born jet was short-lived.Comment: 4 figures, 2 tables, accepted for publication in PAS

MicroRNAs in Pancreatic Cancer: Advances in Biomarker Discovery and Therapeutic Implications

Pancreatic cancer remains a formidable malignancy characterized by high mortality rates, primarily attributable to late-stage diagnosis and a dearth of effective therapeutic interventions. The identification of reliable biomarkers holds paramount importance in enhancing early detection, prognostic evaluation, and targeted treatment modalities. Small non-coding RNAs, particularly microRNAs, have emerged as promising candidates for pancreatic cancer biomarkers in recent years. In this review, we delve into the evolving role of cellular and circulating miRNAs, including exosomal miRNAs, in the diagnosis, prognosis, and therapeutic targeting of pancreatic cancer. Drawing upon the latest research advancements in omics data-driven biomarker discovery, we also perform a case study using public datasets and address commonly identified research discrepancies, challenges, and limitations. Lastly, we discuss analytical approaches that integrate multimodal analyses incorporating clinical and molecular features, presenting new insights into identifying robust miRNA-centric biomarkers

A Generalized Minimum Cost Flow Model for Multiple Emergency Flow Routing

During real-life disasters, that is, earthquakes, floods, terrorist attacks, and other unexpected events, emergency evacuation and rescue are two primary operations that can save the lives and property of the affected population. It is unavoidable that evacuation flow and rescue flow will conflict with each other on the same spatial road network and within the same time window. Therefore, we propose a novel generalized minimum cost flow model to optimize the distribution pattern of these two types of flow on the same network by introducing the conflict cost. The travel time on each link is assumed to be subject to a bureau of public road (BPR) function rather than a fixed cost. Additionally, we integrate contraflow operations into this model to redesign the network shared by those two types of flow. A nonconvex mixed-integer nonlinear programming model with bilinear, fractional, and power components is constructed, and GAMS/BARON is used to solve this programming model. A case study is conducted in the downtown area of Harbin city in China to verify the efficiency of proposed model, and several helpful findings and managerial insights are also presented

VLBA 24 and 43 GHz observations of massive binary black hole candidate PKS 1155+251

PKS 1155+251 is a radio-loud quasar source at z=0.203. Observations using very long baseline interferometry (VLBI) at ~2, 5, 8 and 15 GHz show that the structure of the radio source is quite complicated on parsec scales and that the outer hot spots are apparently undergoing a significant contraction. Because these results cannot be fully explained based on the compact symmetric object (CSO) scenario with a radio core located between the northern and southern complexes, we made observations with the Very Long Baseline Array (VLBA) at 24 and 43 GHz to search for compact substructures and alternative interpretations. The results show that the radio core revealed in the previous VLBI observations remains compact with a flat spectrum in our sub-milli-arcsecond--resolution images; the northern lobe emission becomes faint at 24 GHz and is mostly resolving out at 43 GHz; the southern complex is more bright but has been resolved into the brightest southern-end (S1) and jet or tail alike components westwards. Explaining the southern components aligned westward with a standard CSO scenario alone remains a challenge. As for the flatter spectral index of the southern-end component S1 between 24 and 43 GHz in our observations and the significant 15 GHz VLBA flux variability of S1, an alternative scenario is that the southern complex may be powered by a secondary black hole residing at S1. But more sensitive and high-resolution VLBI monitoring is required to discriminate the CSO and the binary black hole scenarios.Comment: 7 pages, 3 figures, accepted by MNRA

Satisfaction among early and mid-career dentists in a metropolitan dental hospital in China

A growing body of research has examined career satisfaction among dentists using a standardized instrument, dentist satisfaction survey (DSS). This project examined career satisfaction of early to mid-career dentists in China, a population whose career satisfaction, heretofore, has not been studied. This is an especially critical time to examine career satisfaction because of health care reform measures being implemented in China. A culturally sensitive Chinese-language version of the DSS (CDSS) was developed and electronically administered to 367 early and mid-career dentists in a tertiary dental hospital in Beijing, China. One hundred and seventy respondents completed the survey. The average total career score was 123, with a range of 82–157. Data analysis showed some significant differences in total career score and several subscales based on gender, working hours per week, and years in practice. A stepwise regression model revealed that two variables predicted total career score: working hours per week and gender. Stepwise regression also demonstrated that four subscales significantly predicted the overall professional satisfaction subscale score: respect, delivery of care, income and patient relations. Implications of these results are discussed in light of the health care delivery system and dentist career paths in China