47 research outputs found

    Influence of the presence of a methyl group on the myocardial metabolism of 15-(paraiodophenyl)-3 methyl pentadecanoic acid (IMPPA).

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    International audienceThe objective of the present study was to determine the mechanism of accumulation of myocardial activity following i.v. injection of 15-(paraiodophenyl)-3 methyl pentadecanoic acid (IMPPA). IMPPA and 15 phenyl-3 methyl pentadecanoic acid (MPPA) were labeled with 14C at position 1 and used to perfuse isolated rat hearts in a closed system. After 5 min of perfusion, IMPPA reached 2/3 of its value at 45 min. 14CO2 production was low. Most of the myocardial activity was in the form of free IMPPA. Analysis of IMPPA activation by CoA SH revealed that it was very strongly inhibited. The retention of myocardial activity is thus due to intracellular accumulation of free IMPPA following inhibition of activation. Comparison of results obtained with IMPPA and MPPA showed that the presence of iodine in the molecule accentuates the inhibition of activation

    Assessment of iodohexadecenoic acid as a tracer of fatty acid metabolism by external detection: a study on isolated rat heart.

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    International audienceLabelled fatty acids have been proposed to explore cardiac metabolism. For the analysis of the external detection curve obtained with 16-iodo 9-hexadecenoic acid (IHA), we developed a mathematical 4-compartment model with compartments 0, 1, 2 and 3 representing vascular IHA, intracellular IHA, esterified forms and iodide, respectively. This model, used here for isolated rat hearts perfused in a recirculating system, is validated by an intracellular analysis, then tested in various metabolic conditions. Thus, the mathematical analysis of the external detection curve gives us numerical data on IHA metabolism, especially the distribution between degradation and storage. Our results confirm the suitability of IHA for assessing myocardial metabolism

    Le catholicisme en chantiers

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    Depuis près d'un demi-siècle, l'histoire religieuse a constitué l'un des domaines les plus féconds de la recherche universitaire dédiée à la période contemporaine en France. Le renouvellement de ses questionnements a été régulier et ses acquis sont considérables. Elle doit relever aujourd'hui de nouveaux défis liés tout à la fois aux mutations du religieux dans les sociétés contemporaines et aux déplacements de la recherche au sein de l'institution universitaire. C'est dans cette double perspective que quatorze chercheurs de diverses générations s'interrogent dans cet ouvrage sur les axes de renouvellement nécessaires de l'histoire du catholicisme français contemporain autour de quatre pôles : politique et culture, société et changement social, institutions et pratiques, circulations et connexions. Ils ont en commun le souci de défendre la spécificité de leur objet d'étude et de la démarche qui lui est appliquée mais aussi la préoccupation du dialogue avec les autres champs de l'histoire contemporaine et les sciences humaines ou sociales
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