Common Hysterosalpingographic Findings in Infertility Cases in Lagos State, Nigeria.

Background: Reproductive medicine has recently witnessed advances and hysterosalpingography has become a relatively quick and non-invasive procedure to evaluate the uterine cavity and fallopian tubes.Purpose: This study was carried out to evaluate the common hysterosalpingographic findings in infertility cases in Lagos, South West, Nigeria.Materials and Methods: The HSG reports of 100 patients who were referred to the department of radiodiagnosis of Lagos University Teaching Hospital between September 2010 and August 2011 were reviewed. The biodata of each patient was collated from the request forms. Fifty-seven patients (57%) were investigated for secondary infertility, while 43 patients (43%) were investigated for primary infertility.Results: The commonest pathology found in patients presenting with infertility in this study were uterine fibroid (26%), followed by uterine adhesion (12%). There was evidence of peritubal adhesion, either bilateral or unilateral, in 10% of the patients, while tubal occlusion, either bilateral or unilateral, was reported in 7% of the cases. Hydrosalpinx occurred in only 6% of the patients. Twenty-eight patients (28%) had normal uterus and fallopian tubes.Conclusion: Hysterosalpingography remains relevant in the investigation of mechanical causes of infertility in women

Complications of Breast Milk Application to the Infected Eye

Objective: To report complications resulting from the applicationof breast milk to the infected and injured eye seen at the University of Benin Teaching Hospital (UBTH) between June 1st 2006 and July 31st 2007.Methodology: This is a prospective study of five consecutivepatients who had breast milk applied to their eyes. They wereseen at the eye clinic of the University of Benin Teaching Hospital between June 1st 2006 and July 31st 2007. The sex, age, symptoms and signs, visual acuity, treatment and ocular complications were noted.Results: Four (80%) of the patients developed complications following instillation of breast milk in the eyes. Two patients developed endophthalmitis, 1 for bacterial conjunctivitis and 1 for trauma; 1 patient developed panophthalmitis, and the fourth developed endophthalmitis. One child with bacterial conjunctivitis did not develop any complication.Conclusion: Four out of the five patients studied lost vision in theaffected eye after developing endophthalmitis and panophthalmitis following breast milk instillation in the infected and injured eyes

Motivation to Learn, Quality of Life and Estimated Academic Achievement: Medical Students Studying in New Zealand

The quality of life of medical students and their motivation to learn are critical factors that have an impact on their ability to learn. The aim of this study was to investigate the associations between medical students' perceptions of their quality of life, motivation to learn, and estimated grade at the end of the academic year. Two hundred and seventy-four medical students at years four and five of medical school participated in the study. Students filled in a demographic survey form, and shortened versions of the World Health Organization Quality of Life Questionnaire and the Motivated Strategies for Learning Questionnaire. Significant correlations between quality of life and motivation to learn measures were obtained. Second, students who scored high on aspects of quality of life and motivation to learn also scored significantly higher on estimates of written grade. In conclusion, the results suggest that medical students’ perceptions about quality of life and motivation to learn are linked to estimation of academic achievement. The findings of this study further resonate with a key conceptual model in the motivation literature, which promotes the importance of creating opportunities for mastery learning, engaging task value, producing optimal learning contexts, and creating mechanisms for coping with and managing the inevitable anxiety-provoking learning experiences that medical students face.The quality of life of medical students and their motivation to learn are critical factors that have an impact on their ability to learn. The aim of this study was to investigate the associations between medical students‟ perceptions of their quality of life, motivation to learn, and estimated grade at the end of the academic year. Two hundred and seventy-four medical students at years four and five of medical school participated in the study. Students filled in a demographic survey form, and shortened versions of the World Health Organization Quality of Life Questionnaire and the Motivated Strategies for Learning Questionnaire. Significant correlations between quality of life and motivation to learn measures were obtained. Second, students who scored high on aspects of quality of life and motivation to learn also scored significantly higher on estimates of written grade. In conclusion, the results suggest that medical students‟ perceptions about quality of life and motivation to learn are linked to estimation of academic achievement. The findings of this study further resonate with a key conceptual model in the motivation literature, which promotes the importance of creating opportunities for mastery learning, engaging task value, producing optimal learning contexts, and creating mechanisms for coping with and managing the inevitable anxiety-provoking learning experiences that medical students face

Knowledge, Attitude, and Healthcare-Seeking Behavior Towards Dysmenorrhea among Female Students of a Private University in Ogun State, Nigeria

Background: Dysmenorrhea, especially when it is severe, has been associated with a restriction of activity and absence from school or work. Despite this substantial effect on their quality of life and general wellbeing, few women and adolescents with dysmenorrhea seek treatment as they believe it would not help. Aim: The objective of this study was to assess the knowledge, attitude, and healthcare-seeking behavior towards dysmenorrhea among female students of a Private University in Ogun State, Nigeria. Subjects and Methods: Using a descriptive study design, 315 female students were randomly selected to participate in the study. Participants were given structured questionnaire to complete. Data collected were analyzed using Statistical Package for Social Sciences (SPSS) 16.0 and were presented in tables reporting frequency counts and percentages. Statistical significant tests were conducted using chi-square. Result: Dysmenorrhea was reported in 78.1% (242/310) with majority ignoring the pain. Less than average 40.6% (126/310) of the participants had high knowledge about dysmenorrhea and 63.5% (197/310) had negative attitude towards dysmenorrhea. Major effects of dysmenorrhea included restriction from physical activities in 77.2% (187/242) and social withdrawal in 59.1% (143/242). Findings revealed a statistically significant relationship between the age of respondents and their healthcare-seeking behavior towards dysmenorrhea (P < 0.01). Conclusion: Findings from this study indicate the need to design regular reproductive health programs for female undergraduates including information on how to monitor and manage menstrual problems.Keywords: Adolescents, attitude, dysmenorrhea, healthcare-seeking behavior, knowl

Low-cost global MPPT scheme for photovoltaic systems under partially shaded conditions

Maximum Power Point Tracking (MPPT) is a technique applied to improve the efficiency of power conversion in Photovoltaic (PV) systems. Under partially shadowed conditions, the Power-Voltage (P-V) characteristic exhibits multiple peaks and the existing MPPT methods such as the Perturb and Observe (P&O) are incapable of searching for the Global Maximum Power Point (GMPP). This paper proposes a low-cost on-line MPPT scheme to overcome this drawback. By using hybrid numerical searching process, the operating point approaches Local Maximum Power Points (LMPPs) gradually and the GMPP is caught by comparing all the LMPPs. Simulation results prove the effectiveness and correctness of the proposed method. © 2013 IEEE.published_or_final_versio

Aged garlic extract reduces low attenuation plaque in coronary arteries of patients with diabetes: A randomized, double-blind, placebo-controlled study.

Several previous studies have demonstrated that aged garlic extract (AGE) inhibits the progression of coronary artery calcification and non-calcified plaque (NCP) in the general population. However, its effects on plaque progression in patients with diabetes have not yet been investigated, at least to the best of our knowledge. This study investigated whether AGE reduces the coronary plaque volume measured by cardiac computed tomography angiography (CCTA) in patients with diabetes mellitus (DM). A total of 80 participants with DM with a median age of 57 years were prospectively assigned to consume 2,400 mg AGE/day (after completion, 37 participants) or placebo (after completion, 29 participants) orally. Both groups underwent CCTA at baseline and follow-up 365 days apart. In total, 66 participants completed the study. Coronary plaque volume, including total plaque (TP), dense calcium (DC), fibrous, fibro-fatty and low-attenuation plaque (LAP) volumes were measured based upon pre-defined intensity cut-off values using semi-automated software (QAngio CT). Changes in various plaque types were normalized to the total coronary artery length. The non-parametric Wilcoxon rank-sum test was performed to examine the differences in plaque formation between the 2 groups. No significant differences were found in the baseline characteristics between the AGE and placebo groups. Compared with the placebo group, the AGE group exhibited a statistically significant regression in normalized LAP [median and standard deviation (SD) -0.2 (18.8) vs. 2.5 (69.3), P=0.0415]. No differences were observed in TP, fibrous, or fibrofatty plaque volumes between the AGE and placebo group. On the whole, this study indicated that the %LAP change in the AGE group was significantly greater than that in the placebo group in patients with diabetes. However, further studies are warranted to evaluate whether AGE has the ability to stabilize vulnerable plaque and decrease adverse cardiovascular events

Pharmacokinetic Interactions between the Hormonal Emergency Contraception, Levonorgestrel (Plan B), and Efavirenz

Objectives. Compare the Plan B levonorgestrel (LNG) area under the concentration- time curve (AUC12) prior to and with efavirenz (EFV). Design. Prospective, open-label, single-arm, equivalence study. Methods. Healthy HIV-negative subjects underwent 12 hr intensive pharmacokinetic (PK) sampling following single dose LNG alone and after 14 days of EFV. Geometric means, Geometric Mean Ratios, and 90% confidence intervals (CI) are reported for PK Parameters. T-tests were utilized. Clinical parameters and liver function tests (LFTs) were assessed. Results. 24 women enrolled and 21 completed the study. With EFV, LNG AUC12 was reduced 56% (95% CI: 49%, 62%) from 42.9 to 17.8 ng∗hr/mL, and maximum concentration (Cmax⁡) was reduced 41% (95% CI: 33%, 50%) from 8.4 to 4.6 ng/mL. LNG was well tolerated with no grade 3 or 4 treatment-related toxicities. Conclusions. EFV significantly reduced LNG exposures. Higher LNG doses may be required with EFV. These results reinforce the importance of effective contraception in women taking EFV

Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer.

BACKGROUND:Although canonical Wnt signaling is known to promote tumorigenesis in pancreatic ductal adenocarcinoma (PDAC), a cancer driven principally by mutant K-Ras, the detailed molecular mechanisms by which the Wnt effector β-catenin regulates such tumorigenesis are largely unknown. We have previously demonstrated that β-catenin's differential usage of the Kat3 transcriptional coactivator cyclic AMP-response element binding protein-binding protein (CBP) over its highly homologous coactivator p300 increases self-renewal and suppresses differentiation in other types of cancer. AIM/METHODS:To investigate Wnt-mediated carcinogenesis in PDAC, we have used the specific small molecule CBP/β-catenin antagonist, ICG-001, which our lab identified and has extensively characterized, to examine its effects in human pancreatic cancer cells and in both an orthotopic mouse model and a human patient-derived xenograft (PDX) model of PDAC. RESULTS/CONCLUSION:We report for the first time that K-Ras activation increases the CBP/β-catenin interaction in pancreatic cancer; and that ICG-001 specific antagonism of the CBP/β-catenin interaction sensitizes pancreatic cancer cells and tumors to gemcitabine treatment. These effects were associated with increases in the expression of let-7a microRNA; suppression of K-Ras and survivin; and the elimination of drug-resistant cancer stem/tumor-initiating cells

Occurrence of haemolysin antibodies among sickle cell anaemia patients within Calabar metropolis of Nigeria

The role of alpha () and beta () haemolysins in blood transfusion has been well documented. However, the occurrence of haemolysins and its attending problems in sickle cell anaemia (SCA) patients has limited appearance in the literatures especially in black Africa. This study was therefore designed to investigate the occurrence of and haemolysins in SCA patients within Calabar metropolis. A total of 50 normal controls and 54 SCA patients attending the sickle cell clinic of the University of Calabar Teaching Hospital, Cross River State of Nigeria, were screened for haemolysins and quantitated using standard techniques. The distribution of haemolysins in the SCA patients was (16.7), (11.1) and + (16.7%). Their ABO blood groups were normally distributed in this order O>>A>B>AB (61.1, 20.4, 11.1 and 7.5%, respectively). The occurrence of haemolysin among the Ogroup was 15.2%, while haemolysin was 12.1% and + haemolysin was 30.3%. Control samples gave non-significantly lower haemolysin values than in SCA patients (P>0.05), but in the same order (, 9.0, , 7.0, and +, 9.0%). The higher prevalence of haemolysins in SCA could be a major limiting factor in donation of blood, blood selection and transfusion into SCA patients. Consequently, greater care should be taken during cross match of blood for SCA patients especially in multiple transfusion procedures