1,220 research outputs found
Impact of thermal blanching and thermosonication treatments on watercress (Nasturtium officinale) quality: process optimisation and microstructure evaluation
Tinea nigra by Hortaea werneckii, a report of 22 cases from Mexico
Tinea nigra is a superficial mycosis caused by Hortaea werneckii.
It is an infrequent asymptomatic infection that affects human palms and soles,
and is mostly observed in tropical countries. We evaluate retrospectively
twenty-two confirmed cases of tinea nigra from a total of eleven yr
(1997–2007) and discuss the epidemiology, clinical features and
treatment of this disease. In twelve cases, adults were involved, in 10,
children. In nineteen cases the disorder was located on palms of hands and in
three on soles of feet. In all cases, the obtained isolates were
morphologically identified as Hortaea werneckii and the
identification of ten isolates was retrospectively confirmed with the help of
sequences of the internal transcribed spacer regions of the ribosomal DNA. The
patients received topical treatment with Whitfield ointment, ketoconazole,
bifonazole, or terbinafine. Treatment with keratolytic agents and topical
antifungals was effective
Exclusion of Class III malocclusion candidate loci in Brazilian families
The role played by genetic components in the etiology of the Class III phenotype, a class of dental malocclusion, is not yet understood. Regions that may be related to the development of Class III malocclusion have been suggested previously. The aim of this study was to search for genetic linkage with 6 microsatellite markers (D1S234, D4S3038, D6S1689, D7S503, D10S1483, and D19S566), near previously proposed candidate regions for Class III. We performed a two-point parametric linkage analysis for 42 affected individuals from 10 Brazilian families with a positive Class III malocclusion segregation. Analysis of our data indicated that there was no evidence for linkage of any of the 6 microsatellite markers to a Class III locus at = zero, with data supporting exclusion for 5 of the 6 markers evaluated. The present work reinforces that Class III is likely to demonstrate locus heterogeneity, and there is a dependency of the genetic background of the population in linkage studies
Focusing of geodesic congruences in an accelerated expanding Universe
We study the accelerated expansion of the Universe through its consequences
on a congruence of geodesics. We make use of the Raychaudhuri equation which
describes the evolution of the expansion rate for a congruence of timelike or
null geodesics. In particular, we focus on the space-time geometry contribution
to this equation. By straightforward calculation from the metric of a
Robertson-Walker cosmological model, it follows that in an accelerated
expanding Universe the space-time contribution to the Raychaudhuri equation is
positive for the fundamental congruence, favoring a non-focusing of the
congruence of geodesics. However, the accelerated expansion of the present
Universe does not imply a tendency of the fundamental congruence to diverge. It
is shown that this is in fact the case for certain congruences of timelike
geodesics without vorticity. Therefore, the focusing of geodesics remains
feasible in an accelerated expanding Universe. Furthermore, a negative
contribution to the Raychaudhuri equation from space-time geometry which is
usually interpreted as the manifestation of the attractive character of gravity
is restored in an accelerated expanding Robertson-Walker space-time at high
speeds.Comment: 11 pages, 2 figures. Final version changed to match published version
in JCAP. References updated. Conclusions unchange
Charged and Pseudoscalar Higgs production at a Muon Collider
We consider single charged Higgs () and pseudoscalar Higgs ()
production in association with a gauge boson at colliders. We find
that the tree-level t-channel and s-channel contributions to are enhanced for large values of , allowing
sizeable cross-sections whose analogies at colliders would be very
small. These processes provide attractive new ways of producing such particles
at colliders and are superior to the conventional methods in
regions of parameter space.Comment: 11 pages Latex, 5 figures, formulae added in sections 2.2 and 2.3,
extra discussion in section 2.3, references adde
Inhibition of the PP2A activity by the histone chaperone ANP32B is long-range allosterically regulated by respiratory cytochrome c
Repair of injured DNA relies on nucleosome dismantling by histone chaperones and de-phosphorylation events carried out by Protein Phosphatase 2A (PP2A). Typical histone chaperones are the Acidic leucine-rich Nuclear Phosphoprotein 32 family (ANP32) members, e.g. ANP32A, which is also a well-known PP2A inhibitor (a.k.a. I1PP2A). Here we report the novel interaction between the endogenous family member B—so-called ANP32B—and endogenous cytochrome c in cells undergoing camptothecin-induced DNA damage. Soon after DNA lesions but prior to caspase cascade activation, the hemeprotein translocates to the nucleus to target the Low Complexity Acidic Region (LCAR) of ANP32B; in a similar way, our group recently reported that the hemeprotein targets the acidic domain of SET/Template Activating Factor-Iß (SET/TAF-Iß), which is another histone chaperone and PP2A inhibitor (a.k.a. I2PP2A). The nucleosome assembly activity of ANP32B is indeed unaffected by cytochrome c binding. Like ANP32A, ANP32B inhibits PP2A activity and is thus herein referred to as I3PP2A. Our data demonstrates that ANP32B-dependent inhibition of PP2A is regulated by respiratory cytochrome c, which induces long-distance allosteric changes in the structured N-terminal domain of ANP32B upon binding to the C-terminal LCAR. In agreement with the reported role of PP2A in the DNA damage response, we propose a model wherein cytochrome c is translocated from the mitochondria into the nucleus upon DNA damage to modulate PP2A activity via its interaction with ANP32B. © 2021 The Author(s
M1 Resonances in Unstable Magic Nuclei
Within a microscopic approach which takes into account RPA configurations,
the single-particle continuum and more complex
configurations isoscalar and isovector M1 excitations for the unstable nuclei
Ni and Sn are calculated. For comparison, the
experimentally known M1 excitations in Ca and Pb have also been
calculated. In the latter nuclei good agreement in the centroid energy, the
total transition strength and the resonance width is obtained. With the same
parameters we predict the magnetic excitations for the unstable nuclei. The
strength is sufficiently concentrated to be measurable in radioactive beam
experiments. New features are found for the very neutron rich nucleus Ni
and the neutron deficient nucleus Sn.Comment: 17 pages (LATEX), 12 figures (available from the authors),
KFA-IKP(TH)-1993-0
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