2,376 research outputs found
STOL aircraft transient ground effects. Part 1: Fundamental analytical study
The first phases of a fundamental analytical study of STOL ground effects were presented. Ground effects were studied in two dimensions to establish the importance of nonlinear effects, to examine transient aspects of ascent and descent near the ground, and to study the modelling of the jet impingement on the ground. Powered lift system effects were treated using the jet-flap analogy. The status of a three-dimensional jet-wing ground effect method was presented. It was shown, for two-dimensional unblown airfoils, that the transient effects are small and are primarily due to airfoil/freestream/ground orientation rather than to unsteady effects. The three-dimensional study showed phenomena similar to the two-dimensional results. For unblown wings, the wing/freestream/ground orientation effects were shown to be of the same order of magnitude as for unblown airfoils. This may be used to study the nonplanar, nonlinear, jet-wing ground effect
Nicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response
Gain-of-function mutations in the mouse nicotinamide mononucleotide adenylyltransferase type 1 (Nmnat1) produce two remarkable phenotypes: protection against traumatic axonal degeneration and reduced hypoxic brain injury. Despite intensive efforts, the mechanism of Nmnat1 cytoprotection remains elusive. To develop a new model to define this mechanism, we heterologously expressed a mouse Nmnat1 non-nuclear-localized gain-of-function mutant gene (m-nonN-Nmnat1) in the nematode Caenorhabditis elegans and show that it provides protection from both hypoxia-induced animal death and taxol-induced axonal pathology. Additionally, we find that m-nonN-Nmnat1 significantly lengthens C. elegans lifespan. Using the hypoxia-protective phenotype in C. elegans, we performed a candidate screen for genetic suppressors of m-nonN-Nmnat1 cytoprotection. Loss of function in two genes, haf-1 and dve-1, encoding mitochondrial unfolded protein response (mitoUPR) factors were identified as suppressors. M-nonN-Nmnat1 induced a transcriptional reporter of the mitoUPR gene hsp-6 and provided protection from the mitochondrial proteostasis toxin ethidium bromide. M-nonN-Nmnat1 was also protective against axonal degeneration in C. elegans induced by the chemotherapy drug taxol. Taxol markedly reduced basal expression of a mitoUPR reporter; the expression was restored by m-nonN-Nmnat1. Taken together, these data implicate the mitoUPR as a mechanism whereby Nmnat1 protects from hypoxic and axonal injury
A Solution to the Galactic Foreground Problem for LISA
Low frequency gravitational wave detectors, such as the Laser Interferometer
Space Antenna (LISA), will have to contend with large foregrounds produced by
millions of compact galactic binaries in our galaxy. While these galactic
signals are interesting in their own right, the unresolved component can
obscure other sources. The science yield for the LISA mission can be improved
if the brighter and more isolated foreground sources can be identified and
regressed from the data. Since the signals overlap with one another we are
faced with a ``cocktail party'' problem of picking out individual conversations
in a crowded room. Here we present and implement an end-to-end solution to the
galactic foreground problem that is able to resolve tens of thousands of
sources from across the LISA band. Our algorithm employs a variant of the
Markov Chain Monte Carlo (MCMC) method, which we call the Blocked Annealed
Metropolis-Hastings (BAM) algorithm. Following a description of the algorithm
and its implementation, we give several examples ranging from searches for a
single source to searches for hundreds of overlapping sources. Our examples
include data sets from the first round of Mock LISA Data Challenges.Comment: 19 pages, 27 figure
Observed Limits on Charge Exchange Contributions to the Diffuse X-ray Background
We present a high resolution spectrum of the diffuse X-ray background from
0.1 to 1 keV for a ~1 region of the sky centered at l=90, b=+60 using a
36-pixel array of microcalorimeters flown on a sounding rocket. With an energy
resolution of 11 eV FWHM below 1 keV, the spectrum's observed line ratios help
separate charge exchange contributions originating within the heliosphere from
thermal emission of hot gas in the interstellar medium. The X-ray sensitivity
below 1 keV was reduced by about a factor of four from contamination that
occurred early in the flight, limiting the significance of the results. The
observed centroid of helium-like O VII is 568+2-3 eV at 90% confidence. Since
the centroid expected for thermal emission is 568.4 eV while for charge
exchange is 564.2 eV, thermal emission appears to dominate for this line
complex, consistent with much of the high-latitude O VII emission originating
in 2-3 x 10^6 K gas in the Galactic halo. On the other hand, the observed ratio
of C VI Ly gamma to Ly alpha is 0.3+-0.2. The expected ratios are 0.04 for
thermal emission and 0.24 for charge exchange, indicating that charge exchange
must contribute strongly to this line and therefore potentially to the rest of
the ROSAT R12 band usually associated with 10^6 K emission from the Local Hot
Bubble. The limited statistics of this experiment and systematic uncertainties
due to the contamination require only >32% thermal emission for O VII and >20%
from charge exchange for C VI at the 90% confidence level. An experimental gold
coating on the silicon substrate of the array greatly reduced extraneous
signals induced on nearby pixels from cosmic rays passing through the
substrate, reducing the triggered event rate by a factor of 15 from a previous
flight of the instrument.Comment: 14 pages, 7 figures, to be published in Ap
Arctic and subarctic environmental analyses utilizing ERTS-1 imagery
The author has identified the following significant results. ERTS-1 imagery provides a means of distinguishing and monitoring estuarine surface water circulation patterns and changes in the relative sediment load of discharging rivers on a regional basis. Physical boundaries mapped from ERTS-1 imagery in combination with ground truth obtained from existing small scale maps and other sources resulted in improved and more detailed maps of permafrost terrain and vegetation for the same area. Snowpack cover within a research watershed has been analyzed and compared to ground data. Large river icings along the proposed Alaska pipeline route from Prudhoe Bay to the Brooks Range have been monitored. Sea ice deformation and drift northeast of Point Barrow, Alaska have been measured during a four day period in March and shore-fast ice accumulation and ablation along the west coast of Alaska have been mapped for the spring and early summer seasons
Gas damping force noise on a macroscopic test body in an infinite gas reservoir
We present a simple analysis of the force noise associated with the
mechanical damping of the motion of a test body surrounded by a large volume of
rarefied gas. The calculation is performed considering the momentum imparted by
inelastic collisions against the sides of a cubic test mass, and for other
geometries for which the force noise could be an experimental limitation. In
addition to arriving at an accurated estimate, by two alternative methods, we
discuss the limits of the applicability of this analysis to realistic
experimental configurations in which a test body is surrounded by residual gas
inside an enclosure that is only slightly larger than the test body itself.Comment: 8 pages. updated with correct translational damping coefficient for
cylinder on axis. added cylinder orthogonal to symmetry axis, force and
torque. slightly edited throughou
LISA Data Analysis using MCMC methods
The Laser Interferometer Space Antenna (LISA) is expected to simultaneously
detect many thousands of low frequency gravitational wave signals. This
presents a data analysis challenge that is very different to the one
encountered in ground based gravitational wave astronomy. LISA data analysis
requires the identification of individual signals from a data stream containing
an unknown number of overlapping signals. Because of the signal overlaps, a
global fit to all the signals has to be performed in order to avoid biasing the
solution. However, performing such a global fit requires the exploration of an
enormous parameter space with a dimension upwards of 50,000. Markov Chain Monte
Carlo (MCMC) methods offer a very promising solution to the LISA data analysis
problem. MCMC algorithms are able to efficiently explore large parameter
spaces, simultaneously providing parameter estimates, error analyses and even
model selection. Here we present the first application of MCMC methods to
simulated LISA data and demonstrate the great potential of the MCMC approach.
Our implementation uses a generalized F-statistic to evaluate the likelihoods,
and simulated annealing to speed convergence of the Markov chains. As a final
step we super-cool the chains to extract maximum likelihood estimates, and
estimates of the Bayes factors for competing models. We find that the MCMC
approach is able to correctly identify the number of signals present, extract
the source parameters, and return error estimates consistent with Fisher
information matrix predictions.Comment: 14 pages, 7 figure
Spectroscopic and Mechanistic Studies of Heterodimetallic Forms of Metallo-β-lactamase NDM-1
In an effort to characterize the roles of each metal ion in metallo-β-lactamase NDM-1, heterodimetallic analogues (CoCo-, ZnCo-, and CoCd-) of the enzyme were generated and characterized. UV–vis, 1H NMR, EPR, and EXAFS spectroscopies were used to confirm the fidelity of the metal substitutions, including the presence of a homogeneous, heterodimetallic cluster, with a single-atom bridge. This marks the first preparation of a metallo-β-lactamase selectively substituted with a paramagnetic metal ion, Co(II), either in the Zn1 (CoCd-NDM-1) or in the Zn2 site (ZnCo-NDM-1), as well as both (CoCo-NDM-1). We then used these metal-substituted forms of the enzyme to probe the reaction mechanism, using steady-state and stopped-flow kinetics, stopped-flow fluorescence, and rapid-freeze-quench EPR. Both metal sites show significant effects on the kinetic constants, and both paramagnetic variants (CoCd- and ZnCo-NDM-1) showed significant structural changes on reaction with substrate. These changes are discussed in terms of a minimal kinetic mechanism that incorporates all of the data
Extracting galactic binary signals from the first round of Mock LISA Data Challenges
We report on the performance of an end-to-end Bayesian analysis pipeline for
detecting and characterizing galactic binary signals in simulated LISA data.
Our principal analysis tool is the Blocked-Annealed Metropolis Hasting (BAM)
algorithm, which has been optimized to search for tens of thousands of
overlapping signals across the LISA band. The BAM algorithm employs Bayesian
model selection to determine the number of resolvable sources, and provides
posterior distribution functions for all the model parameters. The BAM
algorithm performed almost flawlessly on all the Round 1 Mock LISA Data
Challenge data sets, including those with many highly overlapping sources. The
only misses were later traced to a coding error that affected high frequency
sources. In addition to the BAM algorithm we also successfully tested a Genetic
Algorithm (GA), but only on data sets with isolated signals as the GA has yet
to be optimized to handle large numbers of overlapping signals.Comment: 13 pages, 4 figures, submitted to Proceedings of GWDAW-11 (Berlin,
Dec. '06
Can Modus Vivendi Save Liberalism from Moralism? A Critical Assessment of John Gray’s Political Realism
This chapter assesses John Gray’s modus vivendi-based justification for liberalism. I argue that his approach is preferable to the more orthodox deontological or teleological justificatory strategies, at least because of the way it can deal with the problem of diversity. But then I show how that is not good news for liberalism, for grounding liberal political authority in a modus vivendi undermines liberalism’s aspiration to occupy a privileged normative position vis-à -vis other kinds of regimes. So modus vivendi can save liberalism from moralism, but at cost many liberals will not be prepared to pay
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