Impact of DC Transient Disturbances on Harmonic Performance of Voltage Transformers for AC Railway Applications

This paper analyzes the impact of typical DC transient events occurring in railway grids on the frequency performance of instrument transformers (ITs) installed onboard trains and in AC substations for power quality (PQ) applications. PQ monitoring in railway systems is an issue of great interest because it plays a key role in the improvement of energy efficiency. The measurement chain for the PQ measurements, at 15 kV at 16.7 Hz and 25 kV at 50/60 Hz, commonly includes ITs to scale the voltage to levels fitting the input of the measurement units. Nevertheless, the behavior of ITs in the presence of PQ phenomena represents an open issue from a normative point of view, even for those installed in conventional AC power supply systems. In this context, the paper presents a possible definition of DC transient disturbances test waveforms, a measurement procedure, and a setup to assess the impact of these disturbances on the harmonic performances of ITs for railway systems. Preliminary experimental tests carried out on two commercial ITs under wide ranges of variation for the amplitude and the time duration of DC disturbances show that, in some cases, the error introduced in harmonic measurements can exceed 100%

Carba-D,L-allal- and -D,L-galactal-derived vinyl N-nosyl aziridines as useful tools for the synthesis of 4-deoxy-4-(N-nosylamino)-2,3-unsaturated-5a-carbasugars

The novel carba-D,L-allal- and carba-D,L-galactal-derived vinyl N-nosyl aziridines were prepared and the regio- and stereoselective behavior in opening reactions with O- and N-nucleophiles examined. The carbaglycosylating ability of the novel aziridines, as deduced by the amount of 1,4-addition products (1,4-regioselectivity) obtained in the acid-catalyzed methanolysis taken as a model reaction, is similar or superior to that observed with the corresponding carba-D,L-allal- and -D,L-galactal-derived vinyl epoxides, respectively. In all 1,2- and 1,4-addition products obtained, a –(N-nosylamino) group is regio- and stereoselectively introduced at the C(4) carbon of a 1,2- or 2,3-unsaturated carbasugar, susceptible to further elaborations toward aminocyclitol derivatives. The stereoselective synthesis of the corresponding, enantiomerically pure carba-D,L-allal- and -D,L-galactal-derived vinyl N-acetyl aziridines is also described

Recent Advances in Understanding the Protein Corona of Nanoparticles and in the Formulation of “Stealthy” Nanomaterials

In the last decades, the staggering progress in nanotechnology brought around a wide and heterogeneous range of nanoparticle-based platforms for the diagnosis and treatment of many diseases. Most of these systems are designed to be administered intravenously. This administration route allows the nanoparticles (NPs) to widely distribute in the body and reach deep organs without invasive techniques. When these nanovectors encounter the biological environment of systemic circulation, a dynamic interplay occurs between the circulating proteins and the NPs, themselves. The set of proteins that bind to the NP surface is referred to as the protein corona (PC). PC has a critical role in making the particles easily recognized by the innate immune system, causing their quick clearance by phagocytic cells located in organs such as the lungs, liver, and spleen. For the same reason, PC defines the immunogenicity of NPs by priming the immune response to them and, ultimately, their immunological toxicity. Furthermore, the protein corona can cause the physical destabilization and agglomeration of particles. These problems induced to consider the PC only as a biological barrier to overcome in order to achieve efficient NP-based targeting. This review will discuss the latest advances in the characterization of PC, development of stealthy NP formulations, as well as the manipulation and employment of PC as an alternative resource for prolonging NP half-life, as well as its use in diagnostic applications

Caffeine Intake in College Students

Caffeine is a widely consumed substance that is readily available through many sources that may influence consumption in the college setting. The purpose of this study was to examine the relationship between caffeine intake and sleep behavior and the effect of campus dining frequency on caffeine intake in college students. Three hundred and fifty students (212 males and 138 females) participated in a 72-hour dietary analysis that provided the students’ age, gender, body mass index (BMI), and physical activity level. The students were asked to record dining frequency as well. Ninety-six of the 350 students completed a 7-day sleep diary to complete the sleep analysis. Chi-square tests, regression analysis, and t-tests were performed to analyze relationships and differences between variables. Results showed that there were no significant relationships between caffeine intake and age, gender, BMI, physical activity, sleep time, or frequency of dining and caffeine intake in college students

A new catalytic and enantioselective desymmetrization of symmetrical methylidene cycloalkene oxides

Chiral copper complexes of C2-symmetrical hosphoroamidites were found to be highly effective catalysts for both kinetic resolution and novel desymmetrization reactions of new methylidene epoxycycloalkanes.

A simplified procedure for the accurate frequency response identification of voltage transformers

The paper proposes a simplified and affordable procedure for instrument transformers frequency characterization for medium voltage applications. It consists of a two steps measurement procedure, where both steps involve the generation of sine waves only, so that the it can be easily performed in instrument transformers calibration laboratories without requiring additional generation features. In the first step, a 50 Hz measurement of the Voltage Instrument Transformer ratio error at rated voltage is performed. The second step consists of a frequency sweep performed at low voltage up to the first resonance. By these two data sets, an approximated but accurate frequency response can be easily obtained using a non-linear fitted model. In the paper, a commercial voltage instrument transformer for medium voltage grids is characterized by the proposed method; results are shown and validated by comparison with a reference frequency characterization performed at INRIM under rated voltage. © IMEKO TC-4 2020

Unprecedented catalytic enantioselective trapping of arene oxides with dialkylzinc reagents

The first catalytic enantioselective trapping of symmetrical and racemic arene oxides with organometallic reagents is reported.

Detection of tet(M) gene from raw milk by rapid DNA extraction followed by a two-step PCR with nested primers.

The likelihood that milk and milk products may act as a vehicle for antibiotic-resistant bacterial genes has become a concern to the food industry and a public health issue, and the demand for rapid tests has increased. The purity of DNA extracted from food samples is a key issue in the sensitivity and usefulness of biological analyses, such as PCR for pathogens and nonpathogens. A rapid, phenol-chloroform free method based on a modification of a sodium iodide DNA extraction, followed by a two-step PCR was developed for direct detection of the tet(M) gene in milk samples within a single working day. This study compares the proposed method with a traditional phenol solvent extraction method and with a commercial kit (QIAamp DNA blood mini kit, Qiagen). The three DNA extraction methods were used to ensure access to the tet(M) gene from 1 ml of raw milk, inoculated with a strain of Enterococcus faecalis, which carries the tet(M) gene. The proposed method, followed by a two-step PCR with nested primers specific for the tet(M) gene, was able to reach a detection limit below 10 CFU/ml in less than 4 h, including the two amplification cycles, thus outperforming in sensitivity and rapidity both the traditional and the commercial method

Novel Calibration systems for the dynamic and steady-state testing of digital instrument transformers

Within the frame of the European project 'Future Grid II-Metrology for the next-generation digital substation instrumentation', several partners developed traceable calibration systems which allow the calibration of conventional or non-conventional instrument transformers (IT) even with a sampled value (digital) output according to IEC 61869-9. Different setups are prepared to allow the calibration with complex test waveforms to emulate steady state, dynamic or temporary events during the assessment of the ITs. The laboratory calibration setups for either current transformers or voltage transformers are briefly described. Several results obtained for different kind of voltage or current transformers are presented

Calibration of Current Transformers in distorted conditions

In the context of modern power systems, where there are lots of non-linear loads and generators based on switching power electronics, the accurate measurement of voltage and current harmonics is a key task for the knowledge of the actual state of the network. Voltage and current transducers play a crucial role since they are always the first part of the measurement chain. Currently, classical voltage and current instrument transformers are the most installed transducers, but their performance not always is fully characterized in the presence of distorted waveforms. Therefore, in this paper a calibration setup for the accurate characterization of current transformers with distorted waveforms is presented. System implementation and characterization is presented; then it is employed for the evaluation of the performance of a commercial current transformer in distorted conditions