500 research outputs found
Nonequilibrium Dynamics in the Complex Ginzburg-Landau Equation
We present results from a comprehensive analytical and numerical study of
nonequilibrium dynamics in the 2-dimensional complex Ginzburg-Landau (CGL)
equation. In particular, we use spiral defects to characterize the domain
growth law and the evolution morphology. An asymptotic analysis of the
single-spiral correlation function shows a sequence of singularities --
analogous to those seen for time-dependent Ginzburg-Landau (TDGL) models with
O(n) symmetry, where is even.Comment: 11 pages, 5 figure
Calculation of NMR Properties of Solitons in Superfluid 3He-A
Superfluid 3He-A has domain-wall-like structures, which are called solitons.
We calculate numerically the structure of a splay soliton. We study the effect
of solitons on the nuclear-magnetic-resonance spectrum by calculating the
frequency shifts and the amplitudes of the soliton peaks for both longitudinal
and transverse oscillations of magnetization. The effect of dissipation caused
by normal-superfluid conversion and spin diffusion is calculated. The
calculations are in good agreement with experiments, except a problem in the
transverse resonance frequency of the splay soliton or in magnetic-field
dependence of reduced resonance frequencies.Comment: 15 pages, 10 figures, updated to the published versio
Logarithmically Slow Expansion of Hot Bubbles in Gases
We report logarithmically slow expansion of hot bubbles in gases in the
process of cooling. A model problem first solved, when the temperature has
compact support. Then temperature profile decaying exponentially at large
distances is considered. The periphery of the bubble is shown to remain
essentially static ("glassy") in the process of cooling until it is taken over
by a logarithmically slowly expanding "core". An analytical solution to the
problem is obtained by matched asymptotic expansion. This problem gives an
example of how logarithmic corrections enter dynamic scaling.Comment: 4 pages, 1 figur
Tissue accumulation of cephalothin in burns: A comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers
Burn tissue sites are a potential source of bacteremia during debridement surgery. Burn injury is likely to affect the distribution of antibiotics to tissues, but direct evidence of this is lacking. The aim of this study was to directly evaluate the influence of burn trauma on the distribution of cephalothin to peripheral tissues. We used subcutaneous microdialysis techniques to monitor interstitial fluid concentrations of cephalothin in the burnt and nonburnt tissues of adult patients with severe burns following parenteral administration of 1 g cephalothin for surgical prophylaxis. Analogous simultaneous studies conducted with healthy adult volunteers provided reference tissue concentration data. Equivalent tissue exposures were seen for burn and nonburn sites, giving overall median interstitial cephalothin concentrations (from 0 to 240 min) of 2.84 mg/liter and 3.06 mg/liter, respectively. A lower overall median interstitial cephalothin concentration of 0.54 mg/liter was observed for healthy individuals, and the patient nonburnt tissue and volunteer control tissue cephalothin concentrations exhibited significantly different data distributions (P < 0.001; Kolmogorov-Smirnov nonparametric test). The duration of tissue residence for cephalothin was longer for burn patients than for healthy volunteers. The results demonstrate the potential fallibility of using healthy population models to extrapolate tissue pharmacodynamic predictions from plasma data for burn patients
Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in <em>Trypanosoma brucei</em>
Trypanosoma brucei expresses a diverse repertoire of N-glycans, ranging from oligomannose and paucimannose structures to exceptionally large complex N-glycans. Despite the presence of the latter, no obvious homologues of known β1–4-galactosyltransferase or β1–2- or β1–6-N-acetylglucosaminyltransferase genes have been found in the parasite genome. However, we previously reported a family of putative UDP-sugar-dependent glycosyltransferases with similarity to the mammalian β1–3-glycosyltransferase family. Here we characterize one of these genes, TbGT11, and show that it encodes a Golgi apparatus resident UDP-GlcNAc:α3-d-mannoside β1–2-N-acetylglucosaminyltransferase I activity (TbGnTI). The bloodstream-form TbGT11 null mutant exhibited significantly modified protein N-glycans but normal growth in vitro and infectivity to rodents. In contrast to multicellular organisms, where the GnTI reaction is essential for biosynthesis of both complex and hybrid N-glycans, T. brucei TbGT11 null mutants expressed atypical “pseudohybrid” glycans, indicating that TbGnTII activity is not dependent on prior TbGnTI action. Using a functional in vitro assay, we showed that TbGnTI transfers UDP-GlcNAc to biantennary Man(3)GlcNAc(2), but not to triantennary Man(5)GlcNAc(2), which is the preferred substrate for metazoan GnTIs. Sequence alignment reveals that the T. brucei enzyme is far removed from the metazoan GnTI family and suggests that the parasite has adapted the β3-glycosyltransferase family to catalyze β1–2 linkages
Defect Statistics in the Two Dimensional Complex Ginsburg-Landau Model
The statistical correlations between defects in the two dimensional complex
Ginsburg-Landau model are studied in the defect-coarsening regime. In
particular the defect-velocity probability distribution is determined and has
the same high velocity tail found for the purely dissipative time-dependent
Ginsburg-Landau (TDGL) model. The spiral arms of the defects lead to a very
different behavior for the order parameter correlation function in the scaling
regime compared to the results for the TDGL model.Comment: 24 page
Efficient Algorithm on a Non-staggered Mesh for Simulating Rayleigh-Benard Convection in a Box
An efficient semi-implicit second-order-accurate finite-difference method is
described for studying incompressible Rayleigh-Benard convection in a box, with
sidewalls that are periodic, thermally insulated, or thermally conducting.
Operator-splitting and a projection method reduce the algorithm at each time
step to the solution of four Helmholtz equations and one Poisson equation, and
these are are solved by fast direct methods. The method is numerically stable
even though all field values are placed on a single non-staggered mesh
commensurate with the boundaries. The efficiency and accuracy of the method are
characterized for several representative convection problems.Comment: REVTeX, 30 pages, 5 figure
Damped finite-time-singularity driven by noise
We consider the combined influence of linear damping and noise on a dynamical
finite-time-singularity model for a single degree of freedom. We find that the
noise effectively resolves the finite-time-singularity and replaces it by a
first-passage-time or absorbing state distribution with a peak at the
singularity and a long time tail. The damping introduces a characteristic
cross-over time. In the early time regime the probability distribution and
first-passage-time distribution show a power law behavior with scaling exponent
depending on the ratio of the non linear coupling strength to the noise
strength. In the late time regime the behavior is controlled by the damping.
The study might be of relevance in the context of hydrodynamics on a nanometer
scale, in material physics, and in biophysics.Comment: 9 pages, 4 eps-figures, revtex4 fil
Crystallization of a supercooled liquid and of a glass - Ising model approach
Using Monte Carlo simulations we study crystallization in the
three-dimensional Ising model with four-spin interaction. We monitor the
morphology of crystals which grow after placing crystallization seeds in a
supercooled liquid. Defects in such crystals constitute an intricate and very
stable network which separate various domains by tensionless domain walls. We
also show that the crystallization which occurs during the continuous heating
of the glassy phase takes place at a heating-rate dependent temperature.Comment: 7 page
A developmental analysis of communication between mothers and infants with Down's syndrome
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68850/2/10.1177_027112148300300110.pd
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