2,117 research outputs found
Dynamically-Coupled Oscillators -- Cooperative Behavior via Dynamical Interaction --
We propose a theoretical framework to study the cooperative behavior of
dynamically coupled oscillators (DCOs) that possess dynamical interactions.
Then, to understand synchronization phenomena in networks of interneurons which
possess inhibitory interactions, we propose a DCO model with dynamics of
interactions that tend to cause 180-degree phase lags. Employing an approach
developed here, we demonstrate that although our model displays synchronization
at high frequencies, it does not exhibit synchronization at low frequencies
because this dynamical interaction does not cause a phase lag sufficiently
large to cancel the effect of the inhibition. We interpret the disappearance of
synchronization in our model with decreasing frequency as describing the
breakdown of synchronization in the interneuron network of the CA1 area below
the critical frequency of 20 Hz.Comment: 10 pages, 3 figure
Short-term genome stability of serial Clostridium difficile ribotype 027 isolates in an experimental gut model and recurrent human disease
Copyright: © 2013 Eyre et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedClostridium difficile whole genome sequencing has the potential to identify related isolates, even among otherwise indistinguishable strains, but interpretation depends on understanding genomic variation within isolates and individuals.Serial isolates from two scenarios were whole genome sequenced. Firstly, 62 isolates from 29 timepoints from three in vitro gut models, inoculated with a NAP1/027 strain. Secondly, 122 isolates from 44 patients (2–8 samples/patient) with mostly recurrent/on-going symptomatic NAP-1/027 C. difficile infection. Reference-based mapping was used to identify single nucleotide variants (SNVs).Across three gut model inductions, two with antibiotic treatment, total 137 days, only two new SNVs became established. Pre-existing minority SNVs became dominant in two models. Several SNVs were detected, only present in the minority of colonies at one/two timepoints. The median (inter-quartile range) [range] time between patients’ first and last samples was 60 (29.5–118.5) [0–561] days. Within-patient C. difficile evolution was 0.45 SNVs/called genome/year (95%CI 0.00–1.28) and within-host diversity was 0.28 SNVs/called genome (0.05–0.53). 26/28 gut model and patient SNVs were non-synonymous, affecting a range of gene targets.The consistency of whole genome sequencing data from gut model C. difficile isolates, and the high stability of genomic sequences in isolates from patients, supports the use of whole genome sequencing in detailed transmission investigations.Peer reviewe
COVID-19 pandemic impact on adolescent mental health: a reassessment accounting for development
Current prospective reports suggest a pandemic-related increase in adolescent mental health problems. We examine whether age-related change over 11-14 years accounts for this increase. Mothers and adolescents in a UK-based birth cohort (Wirral Child Health and Development Study; WCHADS; N = 737) reported on adolescent depression and behavioural problems pre-pandemic (December 2019-March 2020), mid-pandemic (June 2020-March 2021) and late pandemic (July 2021-March 2022). Analysis used repeated measures models for over-dispersed Poisson counts with an adolescent-specific intercept with age as a time-varying covariate. Maturational curves for girls, but not for boys, showed a significant increase in self-reported depression symptoms over ages 11-14 years. Behavioural problems decreased for both. After adjusting for age-related change, girls' depression increased by only 13% at mid-pandemic and returned to near pre-pandemic level at late pandemic (mid versus late - 12%), whereas boys' depression increased by 31% and remained elevated (mid versus late 1%). Age-adjusted behavioural problems increased for both (girls 40%, boys 41%) and worsened from mid- to late pandemic (girls 33%, boys 18%). Initial reports of a pandemic-related increase in depression in young adolescent girls could be explained by a natural maturational rise. In contrast, maturational decreases in boys' depression and both boys' and girls' behavioural problems may mask an effect of the pandemic
Electron-beam propagation in a two-dimensional electron gas
A quantum mechanical model based on a Green's function approach has been used
to calculate the transmission probability of electrons traversing a
two-dimensional electron gas injected and detected via mode-selective quantum
point contacts. Two-dimensional scattering potentials, back-scattering, and
temperature effects were included in order to compare the calculated results
with experimentally observed interference patterns. The results yield detailed
information about the distribution, size, and the energetic height of the
scattering potentials.Comment: 7 pages, 6 figure
Purcell enhancement of a single silicon carbide color center with coherent spin control
Silicon carbide has recently been developed as a platform for optically
addressable spin defects. In particular, the neutral divacancy in the 4H
polytype displays an optically addressable spin-1 ground state and
near-infrared optical emission. Here, we present the Purcell enhancement of a
single neutral divacancy coupled to a photonic crystal cavity. We utilize a
combination of nanolithographic techniques and a dopant-selective
photoelectrochemical etch to produce suspended cavities with quality factors
exceeding 5,000. Subsequent coupling to a single divacancy leads to a Purcell
factor of ~50, which manifests as increased photoluminescence into the
zero-phonon line and a shortened excited-state lifetime. Additionally, we
measure coherent control of the divacancy ground state spin inside the cavity
nanostructure and demonstrate extended coherence through dynamical decoupling.
This spin-cavity system represents an advance towards scalable long-distance
entanglement protocols using silicon carbide that require the interference of
indistinguishable photons from spatially separated single qubits.Comment: 13 pages, 4 figure
From multiple perspectives to shared understanding
The aim of this study was to explore how learners operating in a small group reach shared understanding as they work out joint research questions and build a theoretical framework and to identify the resources and tools they used in the process. The learners’ own interpretations of their group activities and learning were also taken into account. The data, consisting of group discussions and the documents produced by the group, were subjected to a qualitative content analysis. The group members employed a variety of resources and tools to exchange their individual perspectives and achieve shared understanding. Summaries of relevant literature laid a foundation for the group’s theoretical discussions. Reflective comparisons between their book knowledge and their personal experiences of online interaction and collaboration were frequent, suggesting that such juxtapositions may have enhanced their learning by intertwining the content to be mastered and the activities entailed by this particular content
Binary Galaxies in the Local Supercluster and Its Neighborhood
We report a catalog of 509 pairs identified among 10403 nearby galaxies with
line-of-sight velocities V_LG < 3500 km/s.We selected binary systems in
accordance with two criteria (bounding and temporal), which require the
physical pair of galaxies to have negative total energy and its components to
be located inside the zero-velocity surface. We assume that individual galaxy
masses are proportional to their total K-band luminosities, M = L_K x 6M/L. The
catalog gives the magnitudes and morphological types of galaxies and also the
projected (orbital) masses and pair isolation indices. The component
line-of-sight velocity differences and projected distances of the binary
systems considered have power-law distributions with the median values of 35
km/s and 123 kpc, respectively. The median mass-to-K-band luminosity ratio is
equal to 11 M/L, and its uncertainty is mostly due to the errors of measured
velocities. Our sample of binary systems has a typical density contrast of d
ro/ro_c ~ 500 and a median crossing time of about 3.5 Gyr. We point out the
substantial fraction of binary systems consisting of late-type dwarf galaxies,
where the luminosities of both components are lower than that of the Small
Magellanic Cloud. The median projected distance for 41 such pairs is only 30
kpc, and the median difference of their line-of-sight velocities is equal to 14
km/s which is smaller than the typical error for radial-velocity (30 km/s).
This specific population of gas-rich dwarf binary galaxies such as I Zw 18 may
be at the stage immediately before merging of its components. Such objects,
which are usually lost in flux-limited (and not distance-limited) samples
deserve a thorough study in the HI radio line with high spatial and velocity
resolution.Comment: published in Astrophysical Bulletin, 2008, Vol. 63, No. 4, pp.
299-34
A genomic epidemiological study shows that prevalence of antimicrobial resistance in Enterobacterales is associated with the livestock host, as well as antimicrobial usage
Enterobacterales from livestock are potentially important reservoirs for antimicrobial resistance (AMR) to pass through the food chain to humans, thereby increasing the AMR burden and affecting our ability to tackle infections. In this study 168 isolates from four genera of the order Enterobacterales, primarily Escherichia coli, were purified from livestock (cattle, pigs and sheep) faeces from 14 farms in the United Kingdom. Their genomes were resolved using long- and short-read sequencing to analyse AMR genes and their genetic context, as well as to explore the relationship between AMR burden and on-farm antimicrobial usage (AMU), in the three months prior to sampling. Although E. coli isolates were genomically diverse, phylogenetic analysis using a core-genome SNP tree indicated pig isolates to generally be distinct from sheep isolates, with cattle isolates being intermediates. Approximately 28 % of isolates harboured AMR genes, with the greatest proportion detected in pigs, followed by cattle then sheep; pig isolates also harboured the highest number of AMR genes per isolate. Although 90 % of sequenced isolates harboured diverse plasmids, only 11 % of plasmids (n=58 out of 522) identified contained AMR genes, with 91 % of AMR plasmids being from pig, 9 % from cattle and none from sheep isolates; these results indicated that pigs were a principle reservoir of AMR genes harboured by plasmids and likely to be involved in their horizontal transfer. Significant associations were observed between AMU (mg kg−1) and AMR. As both the total and the numbers of different antimicrobial classes used on-farm increased, the risk of multi-drug resistance (MDR) in isolates rose. However, even when AMU on pig farms was comparatively low, pig isolates had increased likelihood of being MDR; harbouring relatively more resistances than those from other livestock species. Therefore, our results indicate that AMR prevalence in livestock is not only influenced by recent AMU on-farm but also livestock-related factors, which can influence the AMR burden in these reservoirs and its plasmid mediated transmission
Active flow control systems architectures for civil transport aircraft
Copyright @ 2010 American Institute of Aeronautics and AstronauticsThis paper considers the effect of choice of actuator technology and associated power systems architecture on the mass cost and power consumption of implementing active flow control systems on civil transport aircraft. The research method is based on the use of a mass model that includes a mass due to systems hardware and a mass due to the system energy usage. An Airbus A320 aircraft wing is used as a case-study application. The mass model parameters are based on first-principle physical analysis of electric and pneumatic power systems combined with empirical data on system hardware from existing equipment suppliers. Flow control methods include direct fluidic, electromechanical-fluidic, and electrofluidic actuator technologies. The mass cost of electrical power distribution is shown to be considerably less than that for pneumatic systems; however, this advantage is reduced by the requirement for relatively heavy electrical power management and conversion systems. A tradeoff exists between system power efficiency and the system hardware mass required to achieve this efficiency. For short-duration operation the flow control solution is driven toward lighter but less power-efficient systems, whereas for long-duration operation there is benefit in considering heavier but more efficient systems. It is estimated that a practical electromechanical-fluidic system for flow separation control may have a mass up to 40% of the slat mass for a leading-edge application and 5% of flap mass for a trailing-edge application.This work is funded by the Sixth European Union Framework Programme as part of the AVERT project (Contract No. AST5-CT-2006-030914
The mediating effect of task presentation on collaboration and children's acquisition of scientific reasoning
There has been considerable research concerning peer interaction and the acquisition of children's scientific reasoning. This study investigated differences in collaborative activity between pairs of children working around a computer with pairs of children working with physical apparatus and related any differences to the development of children's scientific reasoning. Children aged between 9 and 10 years old (48 boys and 48 girls) were placed into either same ability or mixed ability pairs according to their individual, pre-test performance on a scientific reasoning task. These pairs then worked on either a computer version or a physical version of Inhelder and Piaget's (1958) chemical combination task. Type of presentation was found to mediate the nature and type of collaborative activity. The mixed-ability pairs working around the computer talked proportionally more about the task and management of the task; had proportionally more transactive discussions and used the record more productively than children working with the physical apparatus. Type of presentation was also found to mediated children's learning. Children in same ability pairs who worked with the physical apparatus improved significantly more than same ability pairs who worked around the computer. These findings were partially predicted from a socio-cultural theory and show the importance of tools for mediating collaborative activity and collaborative learning
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