Spanish expeditions to the Northwest Coast during the Bucareli administration, 1771-1779

No discreet study of the Spanish voyages of discovery and exploration to the northwest coast of North American during the 1770\u27s has been published in English. The purpose of this thesis is to examine the Spanish expeditions of 1774, 1775, and 1779, directed by New Spain\u27s Viceroy Antonio Maria Burareli y Ursua (1771-1779)

Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid excretion in patients with alkaptonuria after 4 weeks of treatment.

BACKGROUND: Alkaptonuria (AKU) is a serious genetic disease characterised by premature spondyloarthropathy. Homogentisate-lowering therapy is being investigated for AKU. Nitisinone decreases homogentisic acid (HGA) in AKU but the dose-response relationship has not been previously studied. METHODS: Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1) was an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study. The primary objective was to investigate the effect of different doses of nitisinone once daily on 24-h urinary HGA excretion (u-HGA24) in patients with AKU after 4 weeks of treatment. Forty patients were randomised into five groups of eight patients each, with groups receiving no treatment or 1 mg, 2 mg, 4 mg and 8 mg of nitisinone. FINDINGS: A clear dose-response relationship was observed between nitisinone and the urinary excretion of HGA. At 4 weeks, the adjusted geometric mean u-HGA24 was 31.53 mmol, 3.26 mmol, 1.44 mmol, 0.57 mmol and 0.15 mmol for the no treatment or 1 mg, 2 mg, 4 mg and 8 mg doses, respectively. For the most efficacious dose, 8 mg daily, this corresponds to a mean reduction of u-HGA24 of 98.8% compared with baseline. An increase in tyrosine levels was seen at all doses but the dose-response relationship was less clear than the effect on HGA. Despite tyrosinaemia, there were no safety concerns and no serious adverse events were reported over the 4 weeks of nitisinone therapy. CONCLUSIONS: In this study in patients with AKU, nitisinone therapy decreased urinary HGA excretion to low levels in a dose-dependent manner and was well tolerated within the studied dose range. TRIAL REGISTRATION NUMBER: EudraCT number: 2012-005340-24. Registered at ClinicalTrials.gov: NCTO1828463

Hoary Bat Habitat Preferences in NYS: Determining a Model for Management Purposes

The hoary bat (Lasiurus cinereus) inhabits New York State, the northern part of its range, from early summer until the early fall. These migratory bats spend the winter in the southern part of their range in the southern United States and Central America. In New York, this tree bat has been documented in several habitat types, from eastern hemlock (Tsuga canadensis) stands to bridge beams; however, its solitary nature, use of high canopy levels for day-roosting, and fast flight make individuals difficult to locate for detailed habitat studies. I am using sonar detection and GIS technology to identify hoary bats in the field and determine habitat characteristics of the areas used by the species. With one field season complete and one more to follow, preliminary statistical analyses have been conducted to determine if there are any trends thus far. Ultimately, these data can then be used to quantify habitat preferences of the hoary bat in New York and develop a habitat model useful for managing this poorly known species

Hoary Bat Habitat Preferences in NYS: Determining a Model for Management Purposes

Environmental Science PanelThe hoary bat (Lasiurus cinereus) inhabits New York State, the northern part of its range, from early summer until the early fall. These migratory bats spend the winter in the southern part of their range in the southern United States and Central America. In New York, this tree bat has been documented in several habitat types, from eastern hemlock (Tsuga canadensis) stands to bridge beams; however, its solitary nature, use of high canopy levels for day-roosting, and fast flight make individuals difficult to locate for detailed habitat studies. I am using sonar detection and GIS technology to identify hoary bats in the field and determine habitat characteristics of the areas used by the species. With one field season complete and one more to follow, preliminary statistical analyses have been conducted to determine if there are any trends thus far. Ultimately, these data can then be used to quantify habitat preferences of the hoary bat in New York and develop a habitat model useful for managing this poorly known species.SUNY BrockportMaster's Level Graduate Research Conferenc

Simulation training as a vehicle for in-service training for houseparents in a residential school for the deaf

There is a well re cognized need for specialized training for house parents in residential schools for the deaf, and there is increasing interest in the preparation and duties of the se staff members. Surveys have indicated that there is little negative reaction to job preparation but there is some conflict in regards to the job expectations of the house parents and thusly the extent and nature of the preparation required. An attempt was made to resolve these differences by Clatterbuck, Roth and Epperson in 1960 in their report to the Conference of Executives. The recommendation of this report was that the Converence set up a certification plan for houseparents.California State University, Northridge. Department of Education.Includes bibliographical references (leaves 34-35)A graduate project presented to the National Leadership Training Program, California State University at Northridge. National Leadership Training Program (NLTP) was established at California State University, Northridge in 1962 by a federal grant to train administrative personnel concerned with rehabilitation of the deaf