Ostracode Mg/Ca paleothermometry in the North Atlantic and Arctic oceans: Evaluation of a carbonate ion effect

The reconstruction of deep-sea bottom water temperature (BWT) is important to assess the ocean's response to and role in orbital- and millennial-scale climate change. Deep-sea paleothermometry employs magnesium to calcium (Mg/Ca) ratios in calcitic benthic microfaunas (foraminifera, ostracodes) as a primary proxy method. Mg/Ca paleothermometry may, however, be complicated by bottom water carbonate ion chemistry, which might affect Mg/Ca ratios in shells. To address temperature and carbonate ion influence on Mg/Ca ratios, we studied Mg/Ca ratios in the benthic ostracode genus Krithe in the North Atlantic and Arctic oceans using a 686-specimen core top collection, including 412 previously unpublished analyses. Mg/Ca ratios are positively correlated to temperature in multiple species from the North Atlantic [BWT = (0.885 × Mg/Ca) − 5.69, r2 = 0.73] and for K. glacialis in the Arctic Ocean and Nordic Seas [BWT = (0.439 × Mg/Ca) − 5.14, r2 = 0.50], consistent with previously published calibrations. We found no evidence for a relationship between Krithe Mg/Ca and carbonate ion saturation in the North Atlantic Ocean, Nordic Seas, and Arctic Ocean, supporting the use of Krithe Mg/Ca for reconstructing past BWT

Norepinephrine-induced acute renal failure: A reversible ischemic model of acute renal failure

Several studies have shown that acute renal failure (ARF) can be produced in the dog by infusing norepinephrine (NE) into a renal artery [1, 2]. In these studies the injury appeared to be confined to the infused kidney, with no changes occurring in systemic hemodynamics or in the function of the contralateral kidney. The hemodynamic changes noted in the infused kidney were comparable to those seen in human ARF. A major criticism of these studies, however, is that the renal failure was not shown to be reversible, as it typically is in man. In the present study, we have reexamined the NE-induced model of ARF in the dog with the particular purpose of finding a set condition which would cause ARF and yet allow recovery of renal function within a period of time comparable to that usually seen in the human disease

Response to freshwater inflow in the Rappahannock Estuary, Virginia : Operation HIFLO \u2778

More sediment, nutrients and pollutants are discharged into an estuary during a few days of flood inflow than during many months or years of average inflow (Meade, 1972; Schubel, 1977), but few observations document the sedimentary response of an estuary to high freshwater inflow. Such inflows are usually unexpected and estuarine water charact~ristics change too rapidly to permit systematic measurements. Moreover, the expenditure of effort and number of sampling vessels required on short notice is beyond the resources of a single research group or institute. Yet, freshwater inflow observations are a key to improving water quality; especially to ameliorate the effects of high turbidity, depleted oxygen and low salinity which can cause oyster motalities (Zaborski and Haven, 1980). Many si9nificant ecological effects are noted by Snedakar, et al., 1977. Exceptional sediment deposition shoals shipping channels, fills boat basins, and blanke~ts oyster grounds. Suspended sediments adsorb toxic contaminates, nutrients and organic matter, and thus can affect plant production and the distribution of shellfish, plants and other life. The HIFLO experiment was planned to observe and evaluate the response of an estuary to high freshwater inflow and high influx of suspended sediment. Of special interest are the questions: How far seaward does the sediment load from an event go before settling to the bed? How do the hydrodynamic conditions for sediment transport change? What is the sequence of estuarine processes triggered by a river flood

Late Holocene sea level variability and Atlantic Meridional Overturning Circulation

Pre-twentieth century sea level (SL) variability remains poorly understood due to limits of tide gauge records, low temporal resolution of tidal marsh records, and regional anomalies caused by dynamic ocean processes, notably multidecadal changes in Atlantic Meridional Overturning Circulation (AMOC). We examined SL and AMOC variability along the eastern United States over the last 2000 years, using a SL curve constructed from proxy sea surface temperature (SST) records from Chesapeake Bay, and twentieth century SL-sea surface temperature (SST) relations derived from tide gauges and instrumental SST. The SL curve shows multidecadal-scale variability (20–30 years) during the Medieval Climate Anomaly (MCA) and Little Ice Age (LIA), as well as the twentieth century. During these SL oscillations, short-term rates ranged from 2 to 4 mm yr−1, roughly similar to those of the last few decades. These oscillations likely represent internal modes of climate variability related to AMOC variability and originating at high latitudes, although the exact mechanisms remain unclear. Results imply that dynamic ocean changes, in addition to thermosteric, glacio-eustatic, or glacio-isostatic processes are an inherent part of SL variability in coastal regions, even during millennial-scale climate oscillations such as the MCA and LIA and should be factored into efforts that use tide gauges and tidal marsh sediments to understand global sea level rise

Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.

Alpha-synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is sufficient to cause early-onset, familial PD. A critical question concerning the molecular pathogenesis of PD is what contributory role, if any, is played by the SNCA gene in sporadic PD. The expansion of SNCA-Rep1, an upstream, polymorphic microsatellite of the SNCA gene, is associated with elevated risk for sporadic PD. However, whether SNCA-Rep1 is the causal variant and the underlying mechanism with which its effect is mediated by remained elusive. We report here the effects of three distinct SNCA-Rep1 variants in the brains of 72 mice transgenic for the entire human SNCA locus. Human SNCA-mRNA and protein levels were increased 1.7- and 1.25-fold, respectively, in homozygotes for the expanded, PD risk-conferring allele compared with homozygotes for the shorter, protective allele. When adjusting for the total SNCA-protein concentration (endogenous mouse and transgenic human) expressed in each brain, the expanded risk allele contributed 2.6-fold more to the SNCA steady-state than the shorter allele. Furthermore, targeted deletion of Rep1 resulted in the lowest human SNCA-mRNA and protein concentrations in murine brain. In contrast, the Rep1 effect was not observed in blood lysates from the same mice. These results demonstrate that Rep1 regulates human SNCA expression by enhancing its transcription in the adult nervous system and suggest that homozygosity for the expanded Rep1 allele may mimic locus multiplication, thereby elevating PD risk

A Web Page Classifier Library Based on Random Image Content Analysis Using Deep Learning

In this paper, we present a methodology and the corresponding Python library 1 for the classification of webpages. Our method retrieves a fixed number of images from a given webpage, and based on them classifies the webpage into a set of established classes with a given probability. The library trains a random forest model build upon the features extracted from images by a pre-trained deep network. The implementation is tested by recognizing weapon class webpages in a curated list of 3859 websites. The results show that the best method of classifying a webpage into the studies classes is to assign the class according to the maximum probability of any image belonging to this (weapon) class being above the threshold, across all the retrieved images. Further research explores the possibilities for the developed methodology to also apply in image classification for healthcare applications.Comment: 4 pages, 3 figures. Proceedings of the 11th PErvasive Technologies Related to Assistive Environments Conference. ACM, 201

How Should Research And Monitoring Be Integrated?

Scientific knowledge of Chesapeake Bay and tidal tributaries has accumulated over many years beginning mostly with descriptive surveys prior to the 1960\u27s and 1970\u27s and evolving towards a coupling of monitoring and research in recent years. This essay discusses the need to more fully couple monitoring and research efforts in the Bay system because such a union of efforts is argued to be the most effective way to assess gross trends in the health of the system (monitoring) and to understand the basic forces causing these trends (research). We argue that together they provide part of the framework necessary for effective management of the living resources of the bay region.https://scholarworks.wm.edu/vimsbooks/1176/thumbnail.jp

Western Arctic Ocean temperature variability during the last 8000 years

Author Posting. © American Geophysical Union, 2011. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 38 (2011): L24602, doi:10.1029/2011GL049714.We reconstructed subsurface (∼200–400 m) ocean temperature and sea-ice cover in the Canada Basin, western Arctic Ocean from foraminiferal δ18O, ostracode Mg/Ca ratios, and dinocyst assemblages from two sediment core records covering the last 8000 years. Results show mean temperature varied from −1 to 0.5°C and −0.5 to 1.5°C at 203 and 369 m water depths, respectively. Centennial-scale warm periods in subsurface temperature records correspond to reductions in summer sea-ice cover inferred from dinocyst assemblages around 6.5 ka, 3.5 ka, 1.8 ka and during the 15th century Common Era. These changes may reflect centennial changes in the temperature and/or strength of inflowing Atlantic Layer water originating in the eastern Arctic Ocean. By comparison, the 0.5 to 0.7°C warm temperature anomaly identified in oceanographic records from the Atlantic Layer of the Canada Basin exceeded reconstructed Atlantic Layer temperatures for the last 1200 years by about 0.5°C.J.R.F., T.M.C., and R.C.T. thank support by USGS Global Change Program, G.S.D. thanks support from the USGS Global Change Program and the NSF Office of Polar Programs, A.d.V. thanks support by Fond québécois de la recherché sur la nature et les technologies (FQRNT) and the Ministere du Développement économique, innovation et exportation (MDEIE) of Quebec.2012-06-1