Use of Protective Lactic Acid Bacteria Adjunct Cultures to Decrease the Incidence of Gas Defects in Cheddar Cheese

Gas production in cheese making is becoming increasingly prevalent in the dairy industry. This gas is produced by microbes that are naturally found in the cheese, and when they metabolize sugar or other sources of energy, they can produce gas. This gas causes slits and cracks in the cheese, which causes the cheese to be worth less and causes issues during slicing and shredding. There are many microbes that cause unwanted gas in cheese, this research focuses on four know gas producers and five other protective microbes that use the same energy sources or have the ability to inhibit the gas producers in some way. Each protective microbe was challenged with all four of the gas producing microbes. The BUILD Dairy program of the Western Dairy Center granted the funding, so that this research could take place. This funding was used to support graduate students as well as for laboratory and manufacturing expenses. The Information that this study yielded data about how the use of protective adjunct cultures can be used to reduce gas production caused by gas producing microbes has been presented at national dairy and cheese industry conferences

The social geography of childcare: 'making up' the middle class child

Childcare is a condensate of disparate social forces and social processes. It is gendered and classed. It is subject to an excess of policy and political discourse. It is increasingly a focus for commercial exploitation. This is a paper reporting on work in progress in an ESRC funded research project (R000239232) on the choice and provision of pre-school childcare by middle class (service class) families in two contrasting London locations. Drawing on recent work in class analysis the paper examines the relationships between childcare choice, middle class fractions and locality. It suggests that on the evidence of the findings to date, there is some evidence of systematic differences between fractions in terms of values, perspectives and preferences for childcare, but a more powerful case for intra-class similarities, particularly when it comes to putting preferences into practice in the 'making up of a middle class child' through care and education

Summary and recommendations

According to Carpenter (1993), the first problem for nutritional science, to identify the chemicals required in a diet to support human growth and maintenance, has been solved. Enough information has been amassed from the study of many populations to enable nutritionists to offer safe recommendations about daily intakes of energy and nutrients for all stages of the human life cycle (see reviews by Nesheim and by Solomons, this volume). Adoption of these recommendations would generally correct deficiency diseases and would reduce the incidence of health complications which are linked to excessive intakes of fat, sodium, alcohol and other substances. Carpenter also drew attention to malnutrition, the solution of which he believed to have become largely political and economic although the fact remains that very many people still do not receive or grow enough food. In the context of this volume, Carpenter's most interesting point was his view that our understanding of the complex relationship between nutrition and disease was still at an early stag

Grobner Bases for Finite-temperature Quantum Computing and their Complexity

Following the recent approach of using order domains to construct Grobner bases from general projective varieties, we examine the parity and time-reversal arguments relating de Witt and Lyman's assertion that all path weights associated with homotopy in dimensions d <= 2 form a faithful representation of the fundamental group of a quantum system. We then show how the most general polynomial ring obtained for a fermionic quantum system does not, in fact, admit a faithful representation, and so give a general prescription for calcluating Grobner bases for finite temperature many-body quantum system and show that their complexity class is BQP

A scanning drift tube apparatus for spatio-temporal mapping of electron swarms

A "scanning" drift tube apparatus, capable of mapping of the spatio-temporal evolution of electron swarms, developing between two plane electrodes under the effect of a homogeneous electric field, is presented. The electron swarms are initiated by photoelectron pulses and the temporal distributions of the electron flux are recorded while the electrode gap length (at a fixed electric field strength) is varied. Operation of the system is tested and verified with argon gas, the measured data are used for the evaluation of the electron bulk drift velocity. The experimental results for the space-time maps of the electron swarms - presented here for the first time - also allow clear observation of deviations from hydrodynamic transport. The swarm maps are also reproduced by particle simulations

Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation

Epithelial barrier tissues such as the skin and airway form an essential interface between the mammalian host and its external environment. These physical barriers are crucial to prevent damage and disease from environmental insults and allergens. Failure to maintain barrier function against such risks can lead to severe inflammatory disorders, including atopic dermatitis and asthma. Here, we discuss the role of the morphogen Sonic Hedgehog in postnatal skin and lung and the impact of Shh signalling on repair, inflammation and atopic disease in these tissues

The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh

Before birth, B cells develop in the fetal liver (FL). In this study, we show that Gli3 activity in the FL stroma is required for B cell development. In the Gli3-deficient FL, B cell development was reduced at multiple stages, whereas the Sonic hedgehog (Hh [Shh])–deficient FL showed increased B cell development, and Gli3 functioned to repress Shh transcription. Use of a transgenic Hh-reporter mouse showed that Shh signals directly to developing B cells and that Hh pathway activation was increased in developing B cells from Gli3-deficient FLs. RNA sequencing confirmed that Hh-mediated transcription is increased in B-lineage cells from Gli3-deficient FL and showed that these cells expressed reduced levels of B-lineage transcription factors and B cell receptor (BCR)/pre-BCR–signaling genes. Expression of the master regulators of B cell development Ebf1 and Pax5 was reduced in developing B cells from Gli3-deficient FL but increased in Shh-deficient FL, and in vitro Shh treatment or neutralization reduced or increased their expression, respectively

Prospects for radical emissions reduction through behaviour and lifestyle change

Over the past two decades, scholars and practitioners across the social sciences, in policy and beyond have proposed, trialled and developed a wide range of theoretical and practical approaches designed to bring about changes in behaviours and lifestyles that contribute to climate change. With the exception of the establishment of a small number of iconic behaviours such as recycling, it has however proved extremely difficult to bring about meaningful transformations in personal greenhouse gas emissions at either the individual or societal level, with multiple reviews now pointing to the limited efficacy of current approaches. We argue that the majority of approaches designed to achieve mitigation have been constrained by the need to operate within prevailing social scientific, economic and political orthodoxies which have precluded the possibility of non-marginal change. In this paper we ask what a truly radical approach to reducing personal emissions would look like from social science perspectives which challenge the unstated assumptions severely limiting action to date, and which explore new alternatives for change. We emphasise the difficulties likely to impede the instituting of genuinely radical societal change regarding climate change mitigation, whilst proposing ways that the ground could be prepared for such a transformation to take place