Studies concerning mass and heat transfer on B7 structured packing

The paper presents theoretical and experimental data concerning mass and heat transfer on B7 structured packing, used for deuterium separation in distillation column. The first section of the paper is dedicated to mass transfer study for hydrogen distillation, and the second section to mass and heat transfer for water distillation. Mathematical model verification was carried out with experimental data, obtained from two laboratory distillation plants for deuterium separation. The experimental data concerning B7 ordered packing efficiency for hydrogen cryogenic distillation at about –250 °C level were obtained from the first plant, and the second plant provided data concerning mass and heat transfer on the same packing for deuterium separation by water vacuum distillation at about 60 °C level. Height of transfer unit and mass and heat transfer coefficients, evaluated theoretically and experimentally, are comparable with those from chemical industry separation processes. This fact justifies the use of multi-tubular column model or transfer process description at distillation column equipped with B7 structured packing

Nitrones: not only extraordinary spin traps, but also good nitric oxide sources in vivo

Free radicals are involved in the development of reperfusion injuries. Using a spin trap, the intensity of such lesions can be reduced. Nitrones (effective in vivo spin traps) were tried in this work as in vivo nitric oxide donors. Nitrite and nitrate concentration values (rabbit blood) were used as biomarkers of nitric oxide production. Most nitrones did not increase plasma concentrations of nitrite and nitrate; on the contrary, reduced plasma concentrations of these indicators were noted. However, glyoxal isopropyldinitrone, in a dose of 50 mg kg–1, was highly effective in increasing nitric oxide production. In the same time, nitrones do not react with hepatic homogenates, proving that the release of nitric oxide takes place in the tissues and is not related to hepatic metabolism. Before using nitrones in vivo, they were tested in vitro for the ability to release nitric oxide following a reaction with the hydroxyl radical

Rezistența la antimicrobiene: amenințare globală pentru sănătatea publică

Ghidul a fost realizat cu suportul proiectului multilateral 22.80013.8007.1M „Phage treatment and wetland technology as intervention strategy to prevent dissemination of antibiotic resistance in surface waters (PhageLand)” din cadrul JPIAMR-ACTION 2021 (2022-2025), Coordonator național Alina Ferdohleb

Large-scale association analyses identify host factors influencing human gut microbiome composition

To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P <5 x 10(-8)) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 x 10(-20)), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 x 10(-10) <P <5 x 10(-8)) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis

IPSAG Cognitive Radio Routing Protocol: Models and Performance

The paper is about performance evaluation of IP Spectrum Aware Geographic routing protocol (IPSAG). IPSAG is an opportunistic cognitive routing protocol which determines a source-destination route in a hop by hop manner, based on both global and local information. Simulation results are reported for a particular case of IPSAG, where the cognitive radio (CR) nodes are uniformly distributed inside the cognitive radio network (CRN), and a two-dimensional random walk model is used to model the mobility of CR nodes. The results show that the IPSAG protocol is performing well in the case of a highly mobile CRN and that the source-destination path is successfully found in the majority of the cases, especially when the network is highly populated

Exploitation of the Isotopic Separation Potential of ASD Production Facility

Exploitation of isotopic separation potential of the heavy water distillation pilot plant was developed in two stages. First step consisted in reorientation of the production to obtain deuterium depleted water (ASD), using just the first stage of the distillation pilot plant. In the second stage it was followed the ASD production increasing, using independently the surplus of packing, existing in ASD production facility. The paper shows the steps of the second stage: determination of the necessary quantity of packing for ASD production, theoretical and experimental verification of the solution for independent operation of the distillation columns and achievement of the necessary investments to implement the proposed solution

Nitrones: not only extraordinary spin traps, but also good nitric oxide sources in vivo

Free radicals are involved in the development of reperfusion injuries. Using a spin trap, the intensity of such lesions can be reduced. Nitrones (effective in vivo spin traps) were tried in this work as in vivo nitric oxide donors. Nitrite and nitrate concentration values (rabbit blood) were used as biomarkers of nitric oxide production. Most nitrones did not increase plasma concentrations of nitrite and nitrate; on the contrary, reduced plasma concentrations of these indicators were noted. However, glyoxal isopropyldinitrone, in a dose of 50 mg kg-1, was highly effective in increasing nitric oxide production. At the same time, nitrones do not react with hepatic homogenates, proving that the release of nitric oxide takes place in the tissues and is not related to hepatic metabolism. Before using nitrones in vivo, they were tested in vitro for the ability to release nitric oxide following a reaction with the hydroxyl radical