18 research outputs found
Inflammatory biomarkers in Alzheimer's disease plasma
Introduction: Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a \u201cHoly Grail\u201d of AD research and intensively sought; however, there are no well-established plasma markers. Methods: A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL; 259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed. Results: Ten analytes showed significant intergroup differences. Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APO\u3b54 adjusted, optimally differentiated AD and CTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Two analytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71). Discussion: Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation
The toxic effects of enzyme inhibitors on muscle and nerve
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The toxic effects of enzyme inhibitors on muscle and nerve
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Geology of the Manchester district : a brief explanation of the geological map Sheet 85 Manchester
This Sheet Explanation provides a summary
of the geology and applied geology of the
district covered by the geological 1:50 000
Series Sheet 85 Manchester, published as
bedrock, and superficial and simplified
bedrock editions in 2010 and 2011
respectively. Further details of the geology
may be found in the references listed in
the Information sources section and in other
literature cited in the text.
The Manchester district lies almost
entirely within the Metropolitan County
of Greater Manchester, with the extreme
south-western part being in Cheshire.
The area supports a population of over
two million people, concentrated in the
cities of Manchester and Salford, and the
surrounding towns of Ashton-under-Lyne,
Oldham, Bury, Bolton, Trafford, and parts
of Rochdale and Stockport. Between these
areas, the land is used for a diverse range
of activities, including agriculture and
industry; there are also extensive tracts of
public open space and amenity areas