a telescope proton recoil spectrometer for fast neutron beam lines

A telescope proton recoil spectrometer for fast neutron beam-lines C. Cazzaniga1,3,∗, M. Rebai2,3, M. Tardocchi3, G. Croci2,3, M. Nocente2,3, S. Ansell1, C. D. Frost1, and G. Gorini2,3 1ISIS Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Didcot OX11 0QX, UK 2Universita degli Studi di Milano-Bicocca, Dipartimento di Fisica, Piazza della Scienza 3, Milano, Italy 3Istituto di Fisica del Plasma "P. Caldirola", Associazione EURATOM-ENEA/CNR, Via Cozzi 53, Milano, Italy ∗E-mail: [email protected]

Evolução dos pacientes com condrossarcoma grau I em relação ao tipo de tratamento cirúrgico

PURPOSE: To evaluate the oncological outcome of patients with grade I chondrosarcomas according to the type of surgical treatment performed, since there is still controversy regarding the need for aggressive resections to reach a successful outcome. MATERIALS AND METHODS: The records of 23 patients with grade I chondrosarcomas were reviewed. The mean age was 38.4 years, ranging from 11 to 70 years; 52% were men and 48% were women. The femur was the site of 13 tumors. The tumors were staged as IA (17, 74%) and IB (6, 26%). Regarding tumor location, 74% (17) were medullary, 22% (5) were peripheral, and 4% (1) was indeterminate. Tumor size ranged from 2 to 25 cm, mean 7.9 cm. Regarding the surgical procedure, 11 patients underwent intralesional resection, 9 patients underwent wide resection, and 3 underwent radical resection. The follow-up period ranged from 24 to 192 months. RESULTS: None of the patients developed local recurrence or metastases; 7 patients had other general complications. CONCLUSIONS: This data supports the use of less aggressive procedures for treatment of low-grade chondrosarcomas.OBJETIVO: Avaliar a evolução oncológica de portadores de condrossarcomas grau I de acordo com o tipo de tratamento cirúrgico efetuado. Existe controvérsia em relação à necessidade de ressecções agressivas para obtenção de uma evolução clínica favorável. MATERIAIS E MÉTODOS: Os prontuários de 23 portadores de condrossarcoma grau I foram analisados. A idade dos pacientes variou de 11 a 70 anos com média de 38,4 anos, 52% eram homens e 48% mulheres. O local mais acometido foi o fêmur com 13 pacientes. Dezessete lesões (74%) foram classificadas como IA e seis (26%) como IB. Setenta e quatro por cento dos tumores eram medulares, 22% eram periféricas e uma lesão indeterminada. O tamanho dos tumores variou de 2 a 25 cm, média de 7,9 cm. Onze pacientes foram submetidos a ressecção intralesional, nove a ressecção ampla e três a ressecção radical. O seguimento variou de 24 a 192 meses. RESULTADOS: Complicações não oncológicas ocorreram em sete pacientes. Nenhum dos pacientes apresentou recidiva local ou metástase. Estes dados sugerem que os procedimentos cirúrgicos menos agressivos são seguros para o tratamento dos pacientes com condrossarcoma grau I

Single-crystal Diamond Detector for DT and DD plasmas diagnostic

Single-crystal Diamond Detectors (SDD) are good candidates as high-energy neutron detectors in the extreme conditions of the next generation thermonuclear fusion facilities like the ITER experiment, due to their high radiation hardness, fast response time and small size. Neutron detection in SDDs is based on the collection of electron-hole pairs produced by charged particles generated by neutron interaction on 12C. In this work the SDD response to neutrons with energies between 2.8 and 3.8MeV was determined at the Legnaro CN accelerator at the INFN Laboratories in Legnaro (PD, Italy). This work is relevant for the characterization of SDDs response functions, which are key points for Deuterium-Deuterium and Deuterium-Tritium plasma diagnostic

Time-stability of a Single-crystal Diamond Detector for fast neutron beam diagnostic under alpha and neutron irradiation

Single-crystal Diamond Detectors (SDDs), due to their good charge carrier transport properties, low leakage and therefore good energy resolution, are good candidates for fast neutron measurement on pulsed spallation sources and fusion plasma experiments. Moreover, diamonds are known to be resistant to neutron irradiation. Nevertheless, measurements show transient effects during irradiation with ionizing particles, as the alpha particle calibration sources. The decrease of the detector counting rate of a counting chain and the pulse height are interpreted as due to a charge trapping inside the detector, which modifies the drift electric field. These instabilities are strongly dependent on the specific type of the interaction. Measurements have been carried out with both alpha particles in the laboratory and neutrons at the ISIS neutron spallation source. We show that these polarization effects are not permanent: the detector performances can be restored by simply inverting the detector bias high voltage. Prime Novelty Statement The measurements described in the paper were performed in order to study the polarization effect in Single-crystal Diamond Detector. This effect was observed under alpha particle and neutron irradiation. With the Transient Current Technique an interpretation of the effect is given

A glycosylation-dependent pathway of non-canonical VEGFR2 activation links tumor hypoxia to vascular remodeling and immunity.

The mechanisms linking tumor hypoxia, neovascularization and immunity are poorlyunderstood. Resistance to VEGF-targeted antiangiogenic therapies suggests thecontribution of non-canonical pathways to hypoxia-driven neovascularization. Wepreviously demonstrated an essential role of galectin-1 (Gal-1) in the control of tumorgrowth by favoring tumor-immune escape. The present study was conducted to elucidatewhether Gal1-glycan lattices link tumor hypoxia to neovascularization and to investigatewhether disruption of these lattices using an anti Gal1 mAb, may contribute to remodelingtumor vascular networks and stimulation of anti-tumor immune responses. For thispurpose, we first examined the ?glycosylation signature? of endothelilal cells (ECs) in restingconditions or exposed to proliferative, tolerogenic, inflammatory or hypoxic stimuli. Incontrast to ECs stimulated with pro-inflammatory stimuli, ECs exposed to tolerogenic,proliferative or hypoxic microenvironment exhibited a substantial up-regulation of therepertoire of cell surface glycans that are critical for Gal-1 binding and angiogenesis(p<0.01). Screening of the phosphorylation status of a spectrum of growth factor receptorsrevealed a 2-fold increase in phosphorylation of VEGFR2, Akt and Erk1/2 upon exposureto Gal1, a pattern comparable to that induced by VEGF. In this regard, pharmacologicalinhibition of Akt or Erk1/2 or interruption of GnTV-mediated N-glycan branching (but notGCNT1-mediated core 2-O-glycan elongation) prevented Gal1 signaling and abrogatedECs proliferation (p<0.01), migration (p<0.01) and angiogenesis (p<0.05). Co-Ipexperiments revealed specific association of Gal1 with VEGFR2 through N-glycandependentinteractions. Consistently, VEGFR2 blockade prevented Gal1-induced ECsmigration (p<0.01) and morphogenesis (p<0.05), whereas blockade of VEGFR1, VEGFR3,or VEGF had no effect, suggesting that signaling established between lectins and glycansmight serve as alternative pathways by mimicking ?cognate ligands?, thus preserving criticalprocesses such as angiogenesis. Furthermore, hypoxia promoted ROS/NF-B-dependentHIF-1-independent up-regulation of tumor Gal1 (p<0.01). mAb- or shRNA-mediateddisruption of Gal1-glycan lattices attenuated hypoxia-driven angiogenesis, while promotingpericyte maturation and vascular remodeling as shown by increased association of ECswith mature pericytes (SMA+, desmin+ and RGS5-) (2-fold; p<0.01), decreased vesseldiameter (2.7 fold; p<0.01) and alleviation of hypoxia in tumors treated with anti-Gal1 mAb.Moreover, anti-Gal-1 mAb-treated tumors showed a significant reduction in tumor growth(p<0.01) and evoked a T-cell specific immune response, as shown by increased T-cellproliferation (p<0.01) and augmented IFN- (p<0.05) and IL-17 (p<0.05) productioncompared to mice receiving control isotype. Moreover, tumor draining LN of mAb-treatedmice had lower frequency of regulatory T cells (p<0.05) and lower IL-10 secretion (p<0.05)compared to mice receiving isotype control. Hence, disruption of lectin-glycan lattices, notonly evokes an unleashed anti tumor immune response, but also reduces angiogenesisand favors remodeling of tumor vascular networks, highlighting the versatility ofendogenous lectins and the dynamics of the ?glycome? during cancer progression.Fil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Salatino, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ouyang, J.. Dana Farber Cancer Institute;Fil: Rubinstein, N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Mascanfroni, Ivan Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Cerliani, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ilarregui, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Sundblad, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Domaica, Carolina Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Dergan Dylon, Leonardo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Croci, M. C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Albini, A.. Istituto Nazionale di Ricovero e Cura a Carattere Scientifico "Saverio de Bellis"; ItaliaFil: Shipp, M. A.. Dana Farber Cancer Institute;Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaKeystone simposia on molecular and celullar biology: new frontiers at the interface of immunity and glycobiologyLake LouisCanadákeystonesymposi

Follow-Up CT Patterns of Residual Lung Abnormalities in Severe COVID-19 Pneumonia Survivors: A Multicenter Retrospective Study

Prior studies variably reported residual chest CT abnormalities after COVID-19. This study evaluates the CT patterns of residual abnormalities in severe COVID-19 pneumonia survivors. All consecutive COVID-19 survivors who received a CT scan 5–7 months after severe pneumonia in two Italian hospitals (Reggio Emilia and Parma) were enrolled. Individual CT findings were retrospectively collected and follow-up CT scans were categorized as: resolution, residual non-fibrotic abnormalities, or residual fibrotic abnormalities according to CT patterns classified following standard definitions and international guidelines. In 225/405 (55.6%) patients, follow-up CT scans were normal or barely normal, whereas in 152/405 (37.5%) and 18/405 (4.4%) patients, non-fibrotic and fibrotic abnormalities were respectively found, and 10/405 (2.5%) had post-ventilatory changes (cicatricial emphysema and bronchiectasis in the anterior regions of upper lobes). Among non-fibrotic changes, either barely visible (n = 110/152) or overt (n = 20/152) ground-glass opacities (GGO), resembling non-fibrotic nonspecific interstitial pneumonia (NSIP) with or without organizing pneumonia features, represented the most common findings. The most frequent fibrotic abnormalities were subpleural reticulation (15/18), traction bronchiectasis (16/18) and GGO (14/18), resembling a fibrotic NSIP pattern. When multiple timepoints were available until 12 months (n = 65), residual abnormalities extension decreased over time. NSIP, more frequently without fibrotic features, represents the most common CT appearance of post-severe COVID-19 pneumonia