Campaña de mercadeo social “Mentalízate : la salud más allá del estado físico"

The following paper is about prevention and promotion of mental health, its main objective is to analyze the current state of the subject and the importance of it in the Ecuadorian community and in a global way. For its realization, first a theoretical investigation was carried out focused both on the reality of Ecuador and on the international, and once the analysis were done the following step was the development of a Social Marketing campaign with the purpose of raising awareness and promoting a culture of prevention on mental health care. The campaign aims to arouse the interest and concern of people about the importance of mental state, as well as having good health does not only involve physical factors, since it is composed equally by the psychological and social part of a person. It began with a plan directed to the National Ballet of Ecuador, in which the campaign was focused and developed. The points covered in this research include: historical background and joint conceptions of academic definitions and factors that determine mental disorders, as well as the perceptions and stigmas that revolve around the theme, national and international legal, programs and models applied both In Latin America as in a national level based on projects proposed by the World Health Organization, specific dance studies related to mental health, statistics and relevant data and the development of the campaign.El siguiente escrito trata sobre la prevención y promoción de la salud mental, su principal objetivo se centra en el análisis del estado actual en el que se encuentra dicho tema y de la importancia del mismo en la comunidad ecuatoriana y de manera global. Para su realización, primero se llevó a cabo una investigación teórica enfocada tanto en la realidad del Ecuador como en la internacional, y una vez realizados los análisis pertinentes se procedió al desarrollo de una campaña de Mercadeo Social con la finalidad de concientizar y promover una cultura de prevención y de cuidado de la salud mental. La campaña tiene como objetivo despertar el interés y preocupación de la gente en cuanto a la importancia del estado mental, así también como el tener una salud adecuada no solo implica los factores físicos, pues está compuesta de igual forma por la parte psicológica y social de las personas. Se inició con un plan piloto dirigido al Ballet Nacional del Ecuador, en el cual se centró y desarrollo la campaña. Los puntos tratados en esta investigación incluyen: antecedentes y concepciones históricas en conjunto de definiciones académicas y factores que determinan trastornos mentales, así como también las percepciones y estigmas que giran en torno al tema, aspectos legales nacionales e internacionales, programas y modelos aplicados tanto en Latinoamérica como a nivel nacional basados en los proyectos de la OMS, estudios específicos de danza relacionados con la salud mental, estadísticas y cifras pertinentes y el desarrollo de la campaña cubriendo los temas

Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia

Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive pulmonary disease, and kidney disease and significantly impedes treatment outcome and therapy tolerance, reducing physical function and increasing mortality. Current cachexia treatments are limited and new pharmacological strategies are needed. Agonists for the growth hormone secretagogue (GHS-R1a), or ghrelin receptor, prospectively regulate the central regulation of appetite and growth hormone secretion, and therefore have tremendous potential as cachexia therapeutics. Non-peptide GHS-R1a agonists are of particular interest, especially given the high gastrointestinal degradation of peptide-based structures, including that of the endogenous ligand, ghrelin, which has a half-life of only 30 min. However, few compounds have been reported in the literature as non-peptide GHS-R1a agonists. In this paper, we investigate the in vitro potential of quinolone compounds to modulate the GHS-R1a in both transfected human cells and mouse hypothalamic cells. These chemically synthesized compounds demonstrate a promising potential as GHS-R1a agonists, shown by an increased intracellular calcium influx. Further studies are now warranted to substantiate and exploit the potential of these novel quinolone-based compounds as orexigenic therapeutics in conditions of cachexia and other metabolic and eating disorders.Irish Research Council for Science and Technology (IRCSET)Science Foundation Ireland (SFI/12/IP/1315)Science Foundation Ireland (SFI/12/RC/2275)Science Foundation Ireland (SFI/12/RC/2273)Universidad de Sevill

Desarrollo de propuesta de modelo de negocio digital: LAVANDERIA QW SV.

En el presente documento se detalla el Desarrollo de propuesta de modelo de negocio digital LAVANDERÍA QW SV con sus respectivas especificaciones que conforman dicho plan incluyendo datos de cada uno de los integrantes. Se toma en cuenta como primera parte la descripción del negocio junta directiva o la forma en la cual está constituida. Se realiza un análisis interno y externo del entorno donde se desarrollará el negocio el cual permitió efectuar un análisis FODA teniendo en cuenta su plan organizacional y como será llevado Organización de gestión además de su distribución en planta. Se ejecuta el plan mercadeo en el cual se analizó los Resultados de la investigación de mercado y metodología a ocupar de la investigación que se ocupó fueron elementos de información secundaria esto debido a la aparición de la enfermedad COVID-19 de que ha venido a cambiar al mundo. En el plan de negocio también se considera su plan de financiero en la cual se demuestra un plan de inversión, el respectivo flujo de efectivo, su rentabilidad el estado de Resultado. El objetivo primordial de este plan es su puesta en marcha y es por eso que se consideran los costos previos como registro de la empresa, así como sus costos que se destinan a la creación como maquinarias y establecimiento del negocio

A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo

Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. Ghrelin is a gut-derived hormone which can stimulate appetite. Herein we describe a novel, simple, non-peptidic, 2-pyridone which acts as a selective agonist for the ghrelin receptor (GHS-R1a). The small 2-pyridone demonstrated clear agonistic activity in both transfected human cells and mouse hypothalamic cells with endogenous GHS-R1a receptor expression. In vivo tests with the hit compound showed significant increased food intake following peripheral administration, which highlights the potent orexigenic effect of this novel GHS-R1a receptor ligand

Chrononutrition and Polyphenols: Roles and Diseases

Biological rhythms can influence the activity of bioactive compounds, and at the same time, the intake of these compounds can modulate biological rhythms. In this context, chrononutrition has appeared as a research field centered on the study of the interactions among biological rhythms, nutrition, and metabolism. This review summarizes the role of phenolic compounds in the modulation of biological rhythms, focusing on their effects in the treatment or prevention of chronic diseases. Heterotrophs are able to sense chemical cues mediated by phytochemicals such as phenolic compounds, promoting their adaptation to environmental conditions. This is called xenohormesis. Hence, the consumption of fruits and vegetables rich in phenolic compounds exerts several health benefits, mainly attributed to the product of their metabolism. However, the profile of phenolic compounds present in plants differs among species and is highly variable depending on agricultural and technological factors. In this sense, the seasonal consumption of polyphenol-rich fruits could induce important changes in the regulation of physiology and metabolism due to the particular phenolic profile that the fruits contain. This fact highlights the need for studies that evaluate the impact of these specific phenolic profiles on health to establish more accurate dietary recommendations.España MINISTERIO DE ECONOMÍA, INDUSTRIA Y COMPETITIVIDAD (AGL2016-77105-R

Administration time effect of dietary proanthocyanidins on the metabolome of Fischer 344 rats is sex- and diet-dependent

Proanthocyanidins (PAs) are one of the most commonly ingested polyphenols in the human diet, with a wide range of beneficial health effects. Remarkably, PAs have been reported to influence core and peripheral clock genes expression, and their effects may change in a time-of-day dependent manner. Therefore, the aim of this study was to investigate whether the capacity of PAs to modulate the metabolome is conditioned by the time-of-day in which these compounds are consumed in a diet- and sexdependent manner. To do this, a grape seed proanthocyanidin extract (GSPE) was administered to female and male Fischer 344 rats at ZT0 (in the morning) and ZT12 (at night) and the GSPE administration time effect was evaluated on clock genes expression, melatonin hormone and serum metabolite levels in a healthy and obesogenic context. The results showed an administration time effect of GSPE on the metabolome in a sex and diet-dependent manner. Specifically, there was an effect on amino acid, lipid and cholate metabolite levels that correlated with the central clock genes expression. Therefore, this study shows a strong influence of sex and diet on the PAs effects on the metabolome, modulated in turn by the time-of-day

Inter-sector participatory strategy in Cuba using an ecosystem approach to prevent dengue transmission at the local level

Cuba está ubicada en una zona de países con alta incidencia de dengue. En los últimos 10 años ha sido afectada por varias epidemias, es por ello que se diseñó, implementó y evaluó una estrategia participativa, basada en el enfoque de ecosalud, la cual estuvo dirigida a propiciar acciones intersectoriales en la gestión del ecosistema para disminuir las poblaciones del mosquito Aedes aegypti y prevenir la transmisión de dengue en el municipio Cotorro de Ciudad de La Habana, Cuba. Para el desarrollo de este trabajo se utilizó la metodología de investigación acción participativa. Como resultado del proceso se pudo describir una estrategia que garantiza la participación activa de la comunidad, los sectores y el gobierno en la producción de ecosistemas saludables, se desarrollaron acciones de prevención y control oportunas e integrados que disminuyeron los riesgos para la proliferación del vector y la transmisión local de la enfermedad. Este enfoque permitió el análisis holístico de los problemas, su priorización y la gestión de sus soluciones; la estrategia se sostiene dos años después de concluido el procesoCuba is located among a group of countries with high dengue incidence. Following several epidemics in the last 10 years, the country designed, implemented, and evaluated a participatory strategy based on the Ecohealth approach. The aim was to promote inter-sector ecosystem management to decrease Aedes aegypti infestation and prevent dengue transmission in the municipality of Cotorro, in Havana city. The study adopted a participatory research methodology. The strategy ensured active participation by the community, diverse sectors, and government in the production of healthy ecosystems. Timely and integrated measures for prevention and control were developed, thereby decreasing the risk of vector proliferation and local dengue transmission. The approach allowed holistic problem analysis, priority setting, and administration of solutions. The strategy has been sustained two years after concluding the process

Modulation of food intake by differential TAS2R stimulation in rat

Metabolic surgery modulates the enterohormone profile, which leads, among other effects, to changes in food intake. Bitter taste receptors (TAS2Rs) have been identified in the gastrointestinal tract and specific stimulation of these has been linked to the control of ghrelin secretion. We hypothesize that optimal stimulation of TAS2Rs could help to modulate enteroendocrine secretions and thus regulate food intake. To determine this, we have assayed the response to specific agonists for hTAS2R5, hTAS2R14 and hTAS2R39 on enteroendocrine secretions from intestinal segments and food intake in rats. We found that hTAS2R5 agonists stimulate glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK), and reduce food intake. hTAS2R14 agonists induce GLP1, while hTASR39 agonists tend to increase peptide YY (PYY) but fail to reduce food intake. The effect of simultaneously activating several receptors is heterogeneous depending on the relative affinity of the agonists for each receptor. Although detailed mechanisms are not clear, bitter compounds can stimulate differentially enteroendocrine secretions that modulate food intake in rats

El derecho del trabajo y la seguridad social en la encrucijada: retos para la disciplina laboral

Ministerio de Economía y Competitividad DER2012-32111Ministerio de Economía y Competitividad DER2015-6936

MiR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2

Myelofibros is (MF) is a myeloproliferative neoplasm characterized by cytopenia and extramedullary hematopoiesis, resulting in splenomegaly. Multiple pathological mechanisms (e.g., circulating cytokines and genetic alterations, such as JAK(V617F) mutation) have been implicated in the etiology of MF, but the molecular mechanism causing resistance to JAK(V617F) inhibitor therapy remains unknown. Among MF patients who were treated with the JAK inhibitor ruxolitinib, we compared noncoding RNA profiles of ruxolitinib therapy responders versus nonresponders and found miR-S43 was significantly upregulated in non responders. We validated these findings by reverse transcription-quantitative PCR. in this same cohort, in 2 additional independent MF patient cohorts from the United States and Romania, and in a JAK2(V617F) mouse model of MF. Both in vitro and in vivo models were used to determine the underlying molecular mechanism of miR-543 in MF. Here, we demonstrate that miR-543 targets the dioxygenases ten-eleven translocation 1 (TET1) and 2 (TET2) in patients and in vitro, causing increased levels of global 5-methylcytosine, while decreasing the acetylation of histone 3, STAT3, and tumor protein p53. Mechanistically, we found that activation of STAT3 by JAKs epigenetically controls miR-543 expression via binding the promoter region of miR-543. Furthermore, miR-543 upregulation promotes the expression of genes related to drug metabolism, including CYP3A4, which is involved in ruxolitinib metabolism. Our findings suggest miR-543 as a potentially novel biomarker for the prognosis of MF patients with a high risk of treatment resistance and as a potentially new target for the development of new treatment options