Pressure–temperature–deformation–time path of a deformed garnet-bearing granite from the Paleoproterozoic Tandilia Belt, Río de la Plata Craton of Argentina

The pressure–temperature (P–T) evolution of a deformed garnet-bearing granite of La Virgen hill, located 25 km south of the town of Azul, Argentina, was studied as an example of the slightly peraluminous and deformed granites widespread in the Paleoproterozoic Tandilia Belt of the Rio de la Plata Craton. An early isobaric magmatic–submagmatic cooling path followed by exhumation was derived by the appraisal of microstructures, chemical compositions of minerals and P–T pseudosection modeling in the system Si–Ti–Al–Fe–Mn–Mg–Ca–Na–K–O–H (1 wt.% of H2O) using the software PERPLE_X. Slightly zoned magmatic garnet with a core composition of pyr4(grs + adr)11sps10alm75 equilibrated with plagioclase (XAn = 0.37) at 6.0 kbar and 655 °C in a crystal mush with < 7 vol.% of melt. The garnet rim composition of pyr3(grs + adr)12sps14alm71, texturally equilibrated with biotite (Mg/(Mg + Fe) = 0.21) at the granitic solidus of 5.9 kbar and 645 °C. The subsequent cooling path is constrained by isopleths of low-Ti muscovite with Si contents of 3.17 per formula unit commonly located around K-feldspar and recrystallized plagioclase (XAn = 0.35). Ductile deformation at low amphibolite- to greenschist-facies metamorphic conditions produced the subvertical main foliation. Forty-two chemical analyses in seven monazite grains of the granite yielded two groups of U–Th–Pb ages at 2126 ± 10 (2σ) Ma and 2089 ± 3 Ma, interpreted to be inherited from widespread magmatic events of the Tandilia Belt and resulted from the granite crystallization, respectively. The exhumation of the deformed granite from middle (~ 22 km) to upper and cold crustal levels was probably a long-lasting process after 1.9 Ga.Fil: Angeletti, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; Argentina. Universidad Nacional del Sur. Departamento de Geología; ArgentinaFil: Martinez, Juan Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; ArgentinaFil: Frisicale, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; ArgentinaFil: Massonne, Hans Joachim. China University Of Geosciences; China. Universität Stuttgart. Fakultät Chemie; Alemani

Aspirin modulates LPS-induced nitric oxide release in rat glial cells

Nitric oxide and prostaglandins are among the numerous substances released by activated glial cells. The aim of this study was to evaluate the effect of high-level aspirin on iNOS expression in cultured rat glial cells treated with lipopolysaccharide (LPS) as pathological stimulator. Using Western Blotting, we verified that aspirin enhanced LPS-induced iNOS expression and the presence of 15-deoxy-Delta(12,14)-prostaglandin (15d-PGJ(2)) suppressed this aspirin effect. However, the exposure of LPS-treated glial cells to aspirin resulted in a decrease of NO production. These results suggest that aspirin interferes with the cross-talk of prostaglandins and NO, blocking the endogenous negative control exerted by COX products on iNOS expression. On the other side, aspirin seems to act directly on iNOS reducing its activity, even if it does not completely block NO release by LPS-stimulated glial cells. Then aspirin could maintain homeostatic functions of NO, while it prevents toxic effects, corresponding to high NO concentrations. (c) 2005 Elsevier Ireland Ltd. All rights reserved

Retrograded mylonitic granulites and phyllonite formation in Azul megashear zone, Tandilia

En el sector norte del Cerro Negro, ubicado en el extremo occidental de la Megacizalla de Azul (MCA), Sierras Septentrionales de la Provincia de Buenos Aires, se destaca la presencia de una faja de filonitas de dirección este-oeste, asociada a granulitas deformadas y retrogradadas, mostrando la gradación completa entre protomilonitas y ultramilonitas. Las filonitas presentan una intensa biotitización de los anfíboles y piroxenos de las rocas originales, y en menor proporción, formación de mica blanca a partir de los feldespatos. Los estudios microtectónicos y la presencia de varios períodos de pseudotaquilización indican que las rocas miloníticas de alto grado características de este sector de la MCA habrían sufrido un cizallamiento posterior, en condiciones dúctil-frágiles acompañado de una removilización de fluidos que originó la retrogradación de las rocas originales, y la consecuente formación de filonitas.At the western end of the Azul megashear zone, which is part of the Sierras Septentrionales of Buenos Aires, an east-west belt of phyllonites occur on the north side of the cerro Negro.These outcrops of phyllonites are associated with deformed and retrogra- ded granulites, showing a complete gradation between protomylonites and ultramylonites. An intense biotitization of amphibo- le and pyroxene of the original rocks becomes dominant, as well as the formation of white mica from feldspar, though in a lesser extent. Microtectonic studies and the identification of several periods of pseudotachylyzation indicate that high grade mylonitic rocks of the Azul megashear zone have undergone subsequent shear deformation under ductile-brittle conditions, accompanied by a remobilization of fluids that caused the retrogression of the original rocks, and the phyllonite formation.Fil: Frisicale, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Geológico del Sur; Argentina. Universidad Nacional del Sur; ArgentinaFil: Angeletti, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Geológico del Sur; Argentina. Universidad Nacional del Sur; ArgentinaFil: Dimieri, Luis Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Geológico del Sur; Argentina. Universidad Nacional del Sur; ArgentinaFil: Martinez, Juan Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Geológico del Sur; Argentina. Universidad Nacional del Sur; ArgentinaFil: Dristas, Jorge A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Geológico del Sur; Argentin

Evidence of a sanukitoid precursor for some Paleoproterozoic granitoids

In this paper new geochemical, geochronological and isotopic Lu–Hf data from the Siempre Amigos Hills (SA), western Tandilia, Argentina, is presented. Outcrops in this small area include representative lithologies of the basement Río de la Plata craton (RPC) known as Tandilia Terrane. The new geochemical data characterize a heterogeneous Paleoproterozoic crust with a similar U–Pb SIMS magmatic age (~2.1 Ga) represented by a suite of mafic (amphibolites, charnockitic granulites), intermediate and felsic compositions (diorites, granodiorites and granitic gneisses), as well as intrusive granitic rocks (with Neoproterozoic age of ~652 Ma in zircon). Geochemical features suggest processes of magmatic differentiation from a mafic igneous protolith associated with the ‘Camboriu orogeny’ of the Trans-Amazonian–Eburnean cycle. Some amphibolites may represent sanukitoid magmas similar to those formed at the Archean-Proterozoic transition. This paper examines the hy-pothesis of a sanukitoid precursor for RPC Rhyacian magmatism. The potassic and calc-alkaline character of magmatic series, together with negative Nb–Ta–Ti anomalies and REE patterns, are compatible with classical modern subduction-related magmas. Precise Lu–Hf analyses of zircons collected from a granodiorite and a gneiss indicate a predominantly juvenile source (+εHf), with minor crustal recycling (-εHf). An inheritance age is recorded in a single Neoarchaean zircon core from a granodiorite (2771 ±15 Ma), similar to calculated maximum Hf TDM (2.8 Ga). Considering the new available data from this region of the RPC, a sustainable petrogenetic model is proposed to explain the presence of geochemical and isotopic evidence of sanukitoid magmatism which may have occurred after 2.7 Ga, which seems to constitute a magmatic series which is a precursor to the development of the Rhyacian magmatic arc in the Tandilia Terrane. Medium-to high-grade metamorphic conditions probably resulted from Paleoproterozoic subduction followed by the intrusion of huge volumes of Rhyacian calc-alkaline magmatism. This model is compatible with RPC configuration as a collage of terranes, and also consistent with Trans-Amazonian–Eburnean amalgamation of various microcontinents in the formation of Atlantica.info:eu-repo/semantics/publishedVersio

Retrogradación de granulitas miloníticas y formación de filonitas en la Megacizalla de Azul, Tandilia

En el sector norte del Cerro Negro, ubicado en el extremo occidental de la Megacizalla de Azul (MCA), Sierras Septentrionales de la Provincia de Buenos Aires, se destaca la presencia de una faja de filonitas de dirección este-oeste, asociada a granulitas deformadas y retrogradadas, mostrando la gradación completa entre protomilonitas y ultramilonitas. Las filonitas presentan una intensa biotitización de los anfíboles y piroxenos de las rocas originales, y en menor proporción, formación de mica blanca a partir de los feldespatos. Los estudios microtectónicos y la presencia de varios períodos de pseudotaquilización indican que las rocas miloníticas de alto grado características de este sector de la MCA habrían sufrido un cizallamiento posterior, en condiciones dúctil-frágiles acompañado de una removilización de fluidos que originó la retrogradación de las rocas originales, y la consecuente formación de filonitas.Retrograded mylonitic granulites and phyllonite formation in Azul megashear zone, Tandilia At the western end of the Azul megashear zone, which is part of the Sierras Septentrionales of Buenos Aires, an east-west belt of phyllonites occur on the north side of the cerro Negro. These outcrops of phyllonites are associated with deformed and retrograded granulites, showing a complete gradation between protomylonites and ultramylonites. An intense biotitization of amphibole and pyroxene of the original rocks becomes dominant, as well as the formation of white mica from feldspar, though in a lesser extent. Microtectonic studies and the identification of several periods of pseudotachylyzation indicate that high grade mylonitic rocks of the Azul megashear zone have undergone subsequent shear deformation under ductile-brittle conditions, accompanied by a remobilization of fluids that caused the retrogression of the original rocks, and the phyllonite formation.Fil: Frisicale, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; ArgentinaFil: Angeletti, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; ArgentinaFil: Dimieri, Luis Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; ArgentinaFil: Martinez, Juan Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; ArgentinaFil: Dristas, Jorge Anastasio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; Argentin

Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells

B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, by combining single-cell RNA and B cell receptor (BCR) sequencing of antigen-specific cells in lymph nodes, spleen, and lungs after influenza infection in mice, we identify several germinal center (GC) B cell subpopulations and organ-specific differences that persist over the course of the response. We discover transcriptional differences between memory cells in lungs and lymphoid organs and organ-restricted clonal expansion. Remarkably, we find significant clonal overlap between GC-derived memory and plasma cells. By combining BCR-mutational analyses with monoclonal antibody (mAb) expression and affinity measurements, we find that memory B cells are highly diverse and can be selected from both low- and high-affinity precursors. By linking antigen recognition with transcriptional programming, clonal proliferation, and differentiation, these finding provide important advances in our understanding of antiviral immunity

Psychometric Properties of the Perinatal Anxiety Screening Scale Administered to Italian Women in the Perinatal Period

Literature stressed the importance of using valid, reliable measures to assess anxiety in the perinatal period, like the self-rated Perinatal Anxiety Screening Scale (PASS). We aimed to examine the psychometric properties of the Italian PASS version in a sample of Italian women undergoing mental health screening during their third trimester of pregnancy and its diagnostic accuracy in a control perinatal sample of psychiatric outpatients. Sample comprised 289 women aged 33.17 ± 5.08, range 19–46 years, undergoing fetal monitoring during their third trimester of pregnancy, with 49 of them retested 6 months postpartum. Controls were 60 antenatal or postnatal psychiatric outpatients aged 35.71 ± 5.02, range 22–50 years. Groups were assessed through identical self- and clinician-rating scales. Confirmatory Factor Analysis (CFA), Principal Component Analysis (PCA), Pearson's correlations and receiver operating characteristic were conducted for PASS. PCA and CPA confirmed four-factor structure with slight differences from the original version. Construct validity and test-retest reliability were supported. Cut-off was 26. The PASS correlated with principal anxiety scales. Despite small sample size, findings confirm reliability and validity of the Italian PASS version in assessing anxiety symptoms in the perinatal period. Its incorporation in perinatal care will improve future mother and child psychological health

Le contestazioni nell'esame dibattimentale

Dottorato di ricerca in procedura penale. 7. ciclo.Consiglio Nazionale delle Ricerche - Biblioteca Centrale - P.le Aldo Moro, 7, Rome; Biblioteca Nazionale Centrale - P.za Cavalleggeri, 1, Florence / CNR - Consiglio Nazionale delle RichercheSIGLEITItal

Petrography, geochemichal characteristics and microstructural analysis of the granite of the Siempre Amigos hill, Azul ranges, Tandilia

El cerro Siempre Amigos integra las sierras de Azul, Tandilia, distante 28 km al sur de la ciudad de Azul, 3 km al norte de la Megacizalla de Azul (MCA), zona de cizalla subvertical donde el basamento se encuentra deformado a milonitas y ultramilonitas (Frisicale et al., 1999). La litología predominante es un granito paleoproterozoico deformado que en el centro y hacia los bordes se encuentra interdigitado con una roca migmatítica y diques de anfibolitas, subverticales con rumbo similar a la foliación milonítica N250º. Todas las rocas presentan rasgos de deformación frágil-dúctil, aunque afectadas por ella con distinta intensidad: anfibolitas y migmatitas poco deformadas y granito llegando a texturas ribbon mylonite y striped gneiss. Mediante el análisis de microestructuras y de mecanismos de deformación actuantes, la deformación estimada es de grado metamórfico medio a alto, con temperaturas entre 400º a 600ºC. El estudio de las orientaciones cristalográficas preferenciales (OPC) de cuarzo dan indicios de mecanismos de aplanamiento próximos a los contactos con las rocas migmatíticas donde se ha generado orientación cristalográfica preferente con marcada simetría, y de componentes de cizallamiento simple hacia el centro de los afloramientos. En cuanto a su geoquímica, se trata de un granito levemente peraluminoso, de ambiente de arco volcánico, sincolisional a postorogénico. Se considera al área de Siempre Amigos, en base a la interpretación de los datos obtenidos, como una zona de transferencia de magma sintectónica que ocurriría dentro de la corteza media a superior en un ambiente de arco magmático con deformación activa.The Siempre Amigos hill is part of the Azul ranges, Tandilia. It is located 28 km to the south of the city of Azul and 3 km to the north of the Azul megashear, a subvertical shear zone which basement is deformed to mylonite and ultramylonites. The Siempre Amigos hill predominant lithology is a Paleoproterozoic granite deformed at the center and interdigitated towards the edges with a gneissic rock and amphibolite bodies, with similar subvertical mylonitic foliation N250º. All rocks show evidence of brittle-ductile deformation although they are affected with variable intensity: they are some less deformed amphibolites and gneiss together with granite reaching ribbon mylonite to striped gneiss textures. Analyzing their microstructure and deformation mechanisms, the deformation can be estimated as medium to high metamorphic grade, with temperatures between 400° to 600°C. The study of preferred crystallographic orientations of quartz gives evidence that there is a crystallographic preferred orientation near to the contacts of the granite with the gneissic rocks, indicating a marked pure shear symmetric deformation, and within the center of the outcrops there is a clear simple shear component. In geochemical terms, the granite is slightly peraluminous and has a volcanic arc syncollisional signature. In summary, the Siempre Amigos area seems to be a syntectonic transfer zone of magma that could happened at middle to upper crust of magmatic arcs with active deformation.Fil: Angeletti, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; ArgentinaFil: Frisicale, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; ArgentinaFil: Dimieri, Luis Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; Argentin