Quality of life in headache suffering children and adolescents: self-report and parent-report.

Background The evaluation of Quality of Life (QOL) in children is different from adults, because it should take into account age-related characteristics. QOL instruments often do not consider the differences between parents and children in reporting the impact of headache on QOL. Patients and methods 272 (158 F, 114 M) headache sufferers (9–15 years old; M=11.59; SD=± 2.03) and their parents (192 mothers; 34 fathers; 59 both parents; 3 care takers) had been enrolled. Both child- ren and their parents filled in the symptomatologic questionnaire and the Impact scale of the Headache Specific Quality of Life of Children (HSQOL-C), in its validated form. Results Factorial Anova showed that the agreement parents-children is significantly higher for 12–15 years old than for 9–11 years old [F(1.255)=10.80; p=0.001]. We found a higher level of congruence between child and parent reports for symptomatologic questionnaire (objective aspects) than Impact scale (subjective aspects). In the latter, headache sufferers obtained higher scores compared to their parents. Conclusions Agreement parents-children increases proportionately with children’s age. It is likely due to the child’s cognitive improve- ment, mental and language skills. QOL instruments should taken into account age-related characteristics of child development

CASE report: Acute hepatic failure secondary to metastatic LIVER\u2019S infiltration by upper tract urothelial carcinoma

INTRODUCTION: Acute liver failure (ALF) secondary to malignant infiltration of the liver from urothelial carcinoma is a very rare clinical condition and is often diagnosed only after death. Upper tract urothelial carcinoma (UTUC) is a rare, from 5% to 10% of all urothelial tumours, but possible cause of ALF when there is extensive liver metastatic involvement. We report the case of a patient who died in the intensive care unit (ICU) of our hospital from multiple organ failure (MOF) secondary to ALF, as a result of infiltration of the liver from UTUC diagnosed after surgery. PRESENTATION OF THE CASE: A 69-year-old Caucasian man was referred to our hospital for hematuria, melena, right upper quadrant (RUQ) pain and jaundice developed over the previous two weeks. After multidisciplinary discussion, he underwent emergency exploratory laparotomy to perform cholecystectomy because of suspected acute cholecystitis considered as a septic focus within the left kidney. He developed MOF and died on the 6thpostoperative day. DISCUSSION: From the diagnosis of the renal mass and the death of the patient, a few days have passed, and the diagnosis of UTUC has been put only at histological examination.The most common sites of metastases from UTUC are lymph nodes, lungs, liver, bones and peritoneum. Moreover, liver metastases have been identified to have an independent negative impact on overall survival in a patient affected by UTUC. CONCLUSION: The authors suggest that this condition should be taken into account when dealing with patients with evidence of a renal mass and simultaneous ALF. KEYWORDS: Acute liver failure, Upper tract urothelial carcinoma (UTUC), emergency surger

Overview of diagnosis and management of paediatric headache. Part I: diagnosis

Headache is the most common somatic complaint in children and adolescents. The evaluation should include detailed history of children and adolescents completed by detailed general and neurological examinations. Moreover, the possible role of psychological factors, life events and excessively stressful lifestyle in influencing recurrent headache need to be checked. The choice of laboratory tests rests on the differential diagnosis suggested by the history, the character and temporal pattern of the headache, and the physical and neurological examinations. Subjects who have any signs or symptoms of focal/progressive neurological disturbances should be investigated by neuroimaging techniques. The electroencephalogram and other neurophysiological examinations are of limited value in the routine evaluation of headaches. In a primary headache disorder, headache itself is the illness and headache is not attributed to any other disorder (e.g. migraine, tension-type headache, cluster headache and other trigeminal autonomic cephalgias). In secondary headache disorders, headache is the symptom of identifiable structural, metabolic or other abnormality. Red flags include the first or worst headache ever in the life, recent headache onset, increasing severity or frequency, occipital location, awakening from sleep because of headache, headache occurring exclusively in the morning associated with severe vomiting and headache associated with straining. Thus, the differential diagnosis between primary and secondary headaches rests mainly on clinical criteria. A thorough evaluation of headache in children and adolescents is necessary to make the correct diagnosis and initiate treatment, bearing in mind that children with headache are more likely to experience psychosocial adversity and to grow up with an excess of both headache and other physical and psychiatric symptoms and this creates an important healthcare problem for their future life

Headache in children

Headache is an extremely frequent symptom in childhood and adolescence, and a common reason for neurological consultation. The prevalence of primary headaches (about 85% in tertiary centers) ranges from 10% to 20% in schoolchildren, and increases with increasing age. No sex difference is apparent until age 11. Female preponderance begins about age 12; during adolescence the female-to-male ratio is about 2:1. A child is not a " little adult" and many developmental and individual factors affect headaches, pertaining to the clinical expression, diagnosis, and therapy of the primary headache. According to this view, several points have to be clarified, beginning by considering the child as a whole as regards his or her development, taking into account neurobiological and psychological maturational processes, familial, social, and environmental factors, and avoiding an adult-focused approach to the disease. It is necessary to find key points in the etiology, pathogenesis, diagnosis, treatment, and outcome of headache in childhood and adolescence. © 2011 Elsevier B.V

Headache in children

Headache is an extremely frequent symptom in childhood and adolescence, and a common reason for neurological consultation. The prevalence of primary headaches (about 85% in tertiary centers) ranges from 10% to 20% in schoolchildren, and increases with increasing age. No sex difference is apparent until age 11. Female preponderance begins about age 12; during adolescence the female-to-male ratio is about 2:1. A child is not a " little adult" and many developmental and individual factors affect headaches, pertaining to the clinical expression, diagnosis, and therapy of the primary headache. According to this view, several points have to be clarified, beginning by considering the child as a whole as regards his or her development, taking into account neurobiological and psychological maturational processes, familial, social, and environmental factors, and avoiding an adult-focused approach to the disease. It is necessary to find key points in the etiology, pathogenesis, diagnosis, treatment, and outcome of headache in childhood and adolescence. © 2011 Elsevier B.V

Supramolecular cages as differential sensors for dicarboxylate anions: Guest length sensing using principal component analysis of ESI-MS and 1 H-NMR raw data

National audienc

Sleep and migraine: an actigraphic study

The aim of the study was to evaluate sleep of children with migraine during the interictal period and the modifications of sleep which precede, are concomitant with, or follow migraine attacks. Eighteen patients with migraine without aura were compared with a group of 17 healthy age-matched children. Sleep parameters were monitored for two full weeks by means of actigraphs and self-report diaries. Headache diaries were also filled out in order to evaluate the occurrence and the characteristics of migraine attacks. Fifty-seven attacks were recorded during the monitoring period. During the interictal period, sleep parameters of children suffering from migraine did not differ from those of controls; only sleep onset latency was slightly prolonged in the migraine group. Timing of the attack affected nocturnal motor activity which presented the lowest values on the night preceding the attack, indicating a decrease in cortical activation during sleep preceding migraine attacks. Further studies should clarify if the observed reduction in nocturnal motor activity close to the attack is related to neurotransmitter imbalance

The Navigation Ability Test (NAT 2.0): From Football Player Performance to Balance Rehabilitation in Chronic Unilateral Vestibular Loss

Aim of the Study: in humans, spatial orientation consists of the ability to move around the environment through memorized and pre-programmed movements, according to the afferent sensory information of the body and environmental analysis of the Central Nervous System (CNS). The purpose of this study is to analyze the abilities of professional athletes, such as footballers, to use mental navigation systems, cognitive maps, and memorized motor patterns in order to obtain better physical performance and to obtain useful information for training both non-sports subjects and vestibular patients for rehabilitation purposes. Materials and Methods: all the motor performances of sportsmen, healthy non-sporting subjects, or vestibular patients are based on the acquisition of visual–spatial and training information. In this study, we analyzed the visual–spatial performance of 60 trained sportsmen (professional footballers), 60 healthy non-sports subjects, and 48 patients affected by chronic unilateral vestibular loss by means of the Navigation Ability Test 2.0. A score based on the number of targets correctly reached in the various tests quantifies the degree of performance of the subjects. Results: NAT 2.0 scores progressively improve from vestibular subjects to healthy non-sporting subjects to footballers. NAT 2.0 scores improve in all three subject groups as the number of tasks performed in all patient groups increases, regardless of gender and age. Conclusions: the analysis of performance data through NAT 2.0 in athletes (footballers) opens new perspectives for rehabilitation purposes, regardless of age, sex, and training conditions, both in healthy non-sporting subjects to improve their sporting potential and in patients affected by chronic vestibular dysfunction, in order to optimize their motor skills and prevent falls