Discovering time-lagged rules from microarray data using gene profile classifiers

Background: Gene regulatory networks have an essential role in every process of life. In this regard, the amount of genome-wide time series data is becoming increasingly available, providing the opportunity to discover the time-delayed gene regulatory networks that govern the majority of these molecular processes.Results: This paper aims at reconstructing gene regulatory networks from multiple genome-wide microarray time series datasets. In this sense, a new model-free algorithm called GRNCOP2 (Gene Regulatory Network inference by Combinatorial OPtimization 2), which is a significant evolution of the GRNCOP algorithm, was developed using combinatorial optimization of gene profile classifiers. The method is capable of inferring potential time-delay relationships with any span of time between genes from various time series datasets given as input. The proposed algorithm was applied to time series data composed of twenty yeast genes that are highly relevant for the cell-cycle study, and the results were compared against several related approaches. The outcomes have shown that GRNCOP2 outperforms the contrasted methods in terms of the proposed metrics, and that the results are consistent with previous biological knowledge. Additionally, a genome-wide study on multiple publicly available time series data was performed. In this case, the experimentation has exhibited the soundness and scalability of the new method which inferred highly-related statistically-significant gene associations.Conclusions: A novel method for inferring time-delayed gene regulatory networks from genome-wide time series datasets is proposed in this paper. The method was carefully validated with several publicly available data sets. The results have demonstrated that the algorithm constitutes a usable model-free approach capable of predicting meaningful relationships between genes, revealing the time-trends of gene regulation. © 2011 Gallo et al; licensee BioMed Central Ltd.Fil: Gallo, Cristian Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación; ArgentinaFil: Carballido, Jessica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación; ArgentinaFil: Ponzoni, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación; Argentin

Comparing crime reporting factors in EU countries

Through crime-reporting citizens make their security needs explicit to the police. This information helps the police in the allocation of resources. In the European Union, there are significant differences among countries, both in terms of overall and specific crime-reporting rates. Factors highlighted by the literature that might explain these differences are not entirely satisfactory (...

Evaluación del potencial turístico de la parroquia Pumallacta, cantón Alausí, provincia de Chimborazo.

El objetivo principal de la siguiente investigación es la evaluación del potencial turístico de la parroquia Pumallacta¸ cantón Alausí, provincia de Chimborazo, mediante la recopilación de información secundaria y la investigación acción participativa. En la primera etapa se validó el diagnóstico situacional a través de la revisión y sistematización del (PDyOT), proyectos técnicos, libros, documentos electrónicos, que tienen relación con registros territoriales e información específica de la parroquia, en la cual se realizó el estudio de los componentes: biofísico, sociocultural, económico, asentamientos humanos, movilidad, energía y conectividad; político institucional y participación ciudadana, en la segunda etapa se determinó el mercado turístico para lo cual se procedió a registrar e inventariar un total de 17 atractivos turísticos de los cuales 7 corresponden a naturales y 10 manifestaciones culturales. Del total de atractivos, 7 poseen jerarquía II, establecido mediante los criterios de las fichas del Ministerio de Turismo del Ecuador, en el análisis de la demanda los turistas nacionales y extranjeros están dispuestos a visitar y conocer la parroquia, realizar actividades como: caminatas, fotografía, senderismo, ciclismo, camping; en relación con lo establecido se pretende captar 3 539 turistas al año. En la tercera y última etapa se procedió a plantear las líneas de aprovechamiento turístico para potenciar el turismo natural y cultural del territorio en el cual se generó una matriz FODA y a partir de esto se priorizó los nudos críticos y factores claves de éxito, los resultados técnicos revelaron: 5 programas y 9 proyectos, con un presupuesto estimado de $143 300 para 5 años.The main objetive of the following reseach is the evaluation of the potential tourism in Pumallacta, Alausí cantón, Chimborazo province, through the collection of secondary information and participatory action research. In the first stage, the situational diagnosis was validate through the review and systematization of the (PDyOT), technical projects, books, and electronic documents, which are related to territorial records and specific information of the parish, in which the study of the following components was carried out: biophysical, socio-cultural, economic, human settlements, mobility, energy, and connectivity; political-institutionaland citizen participation. In the second stage, the tourism market was determined to register and inventory a total of 17 tourist attractions of which 7 correspond to natural and 10 cultural manifestation. Of the total of attractions, 7 have hierarchy II, established by the criteria of the Ministry of Tourism of Ecuador, in the analysis of the demand national and foreing tourists are willing to visit and know the village, perform activities such as: walking, photograply, hiking, cycling, camping; in relation to the established is intended to generate bases for tourism development. In the third and last stage, it proposes the lines of tourism development to enhance the natural and cultural tourism of the territory in which a SWOT matrix was generated and from this, the critical nodes and key success factors were prioritized, the technical results revealed: 5 programs and 9 proyects, with an estimated budget of$143 300 for 5 years

From Barriers To Opportunities, School Inclusion; Identification Of Inclusion Pedagogical Strategies In An Educational Institution

La presente investigación se plantea como propósito la identificación de las estrategias pedagógicas de inclusión que se llevan a cabo en una Institución Educativa de El Peñol - Antioquia tomando coma base el decreto 1421 de 2017 sobre la inclusión escolar. El enfoque es cualitativo con un alcance de tipo descriptivo. Se inicia con una revisión documental de registros institucionales y textos del autor G. Porter que abre el panorama sobre inclusión escolar. Luego, aplica una entrevista a docentes y directivos, para la comprensión terminológica, visualización de dificultades y apreciaciones personales sobre la situación pedagógica de la institución referente a la inclusión. Por último, se realiza una lista de chequeo con base en el decreto 1421 del 2017 para analizar el cumplimiento de la misma en cuanto a la inclusión escolar en la institución. Se concluye la importancia de implementar mayor formación académica en la comunidad educativa en cuanto a la inclusión escolar y la necesidad de mayores recursos económicos y formativos que respondan a los requerimientos para el cumplimiento del decreto.This research aims to identify the pedagogical strategies of inclusion that are carried out in the Educational Institution from El Peñol town, based on Decree 1421 of 2017 on school inclusion. The scope is descriptive, since it is intended to gather specific information on the subject of inclusion in the institution and thus accurately describe it in special contact with the pedagogical strategies present in the institution to carry out the subject of inclusion. This concludes the indisputable option of implementing more academic training in the educational community in general regarding the subject of inclusion, the need for greater economic and training resources that meet the requirements of the decree

Biclustering in data mining using a memetic multi-objective evolutionary algorithm

In this paper, a new memetic strategy that integrates a multi-objective evolutionary algorithm (the SPEA2) with a local search technique for data mining is presented. The algorithm explores a Term Frequency-Inverse Document Frequency (TF-IDF) data matrix in order to find biclusters that fulfill several objectives. The case of study was a dataset corresponding to the Reuters-21578 corpus. Our algorithm performed satisfactorily, finding biclusters that have large size and coherent values, yielding to undeniably promising outcomes. Nonetheless, more experiments with data from other corpus are necessary, thus leading to more concluding resultsWorkshop de Agentes y Sistemas Inteligentes (WASI)Red de Universidades con Carreras en Informática (RedUNCI

Análisis de la satisfacción de los estudiantes y del impacto en el medio laboral de los egresados del programa de Ingeniería Comercial de la facultad de ingenierías de la universidad Libre Seccional Pereira

CD-T 378.009 2 G135; 121 pEl presente trabajo tiene como objetivo entregar el análisis del nivel de satisfacción de los estudiantes y egresados con respecto a la formación recibida y el impacto de los resultados profesionales en el campo laboral del programa de Ingeniería Comercial de la universidad Libre Seccional Pereira. Esta investigación se dividió en tres fases: La primera cuyo fin es determinar las variables para medir el nivel de satisfacción de los estudiantes, así como el impacto en el medio laboral y social de los egresados de Ingeniería Comercial, en la segunda fase se realiza la medición de las variables establecidas mediante el diseño de un instrumento de recolección de datos que permitan su análisis y por último, establecer las recomendaciones como guía del plan acción con base en los resultados obtenidos a través de los valiosos aportes de estudiantes y egresados.Universidad Libre Seccional Pereir

Kinanthropometry and Anatomical Body Composition of Elite Soccer Players in Argentina: The FUTREF Project

Introduction: Anthropometric references for sports enable researchers and sports nutrition professionals to accurately assess body composition in an economical and efficient manner. The objective of this study was to provide an extensive anthropometric profile of elite soccer players divided by playing position. Seven hundred fifty-two players (age 24.0 ± 4.4 years) from 18 different Argentine teams were involved in the FUTREF project and measured according to the protocol defined by the International Society for the Advancement of Kinanthropometry (ISAK). Methods: Raw anthropometric parameters were reported and used to calculate somatotype and body mass components according to molecular (two-components) and anatomical (five-components) models. Results: Statistically significant differences (p>0.01) were identified for anthropometric parameters among different playing positions and between players selected and not selected for the senior national team. The 5th, 25th, 50th, 75th, and 95th percentiles for the muscle-to-bone ratio were provided. Furthermore, the use of different equations showed different outputs in predicting body composition. Conclusion: This study provides anthropometric reference data for evaluating body composition in elite soccer players.Las referencias antropométricas para el deporte permiten a los investigadores y profesionales de la nutrición deportiva evaluar con precisión la composición corporal de una manera económica y eficiente. El objetivo de este estudio fue proporcionar un perfil antropométrico extenso de jugadores de fútbol de élite dividido por posición de juego. En el proyecto FUTREF participaron setecientos cincuenta y dos jugadores (edad 24,0 ± 4,4 años) de 18 equipos argentinos diferentes, medidos según el protocolo definido por la Sociedad Internacional para el Avance de la Cineantropometría (ISAK). Métodos: Se informaron parámetros antropométricos brutos y se utilizaron para calcular los componentes del somatotipo y la masa corporal según modelos moleculares (dos componentes) y anatómicos (cinco componentes). Resultados: Se identificaron diferencias estadísticamente significativas (p>0,01) para los parámetros antropométricos entre las diferentes posiciones de juego y entre jugadores seleccionados y no seleccionados para la selección absoluta. Se proporcionaron los percentiles 5, 25, 50, 75 y 95 para la relación músculo-hueso. Además, el uso de diferentes ecuaciones mostró diferentes resultados en la predicción de la composición corporal. Conclusión: Este estudio proporciona datos antropométricos de referencia para evaluar la composición corporal en jugadores de fútbol de élite

A Software Tool for Discovery of Gene Regulatory Networks: Analysis of Alzheimer Disease Data

A gene regulatory network (GRN) is a collection of molecular regulators that interact with each other to govern the majority of the molecular processes. These networks play a central role in in every process of life, therefore, assembling these networks is rather significant. Since most of the GRN are hard to be mapped with accuracy by a mathematical model, the approaches that are called model-free have an advantage in modeling the complexities of dynamic molecular networks. In particular, a rule-based approach, which is a highly abstract model-free approach, offers several advantages performing data-driven analysis. One of these advantages is that it requires the least amount of data, another one is that its simplicity allows the inference of large size models with a higher speed of analysis. However, the resulting relational structure of the network is incomplete, for an effective biological analysis. This situation has driven us to explore the hybridization with other approaches, such as biclustering techniques. This applied technique finds new relations between the nodes of the existent GRN. In this abstract we present a new software, called GeRNeT that integrates the algorithms of GRNCOP2 and BiHEA along a set of tools for interactive visualization, statistical analysis and ontological enrichment of the resulting GRNs that it was published in Dussaut et al. [1]. In this regard, results associated with Alzheimer disease datasets are presented that show the usefulness of integrating both bioinformatics tools.Sociedad Argentina de Informática e Investigación Operativ

A Software Tool for Discovery of Gene Regulatory Networks: Analysis of Alzheimer Disease Data

A gene regulatory network (GRN) is a collection of molecular regulators that interact with each other to govern the majority of the molecular processes. These networks play a central role in in every process of life, therefore, assembling these networks is rather significant. Since most of the GRN are hard to be mapped with accuracy by a mathematical model, the approaches that are called model-free have an advantage in modeling the complexities of dynamic molecular networks. In particular, a rule-based approach, which is a highly abstract model-free approach, offers several advantages performing data-driven analysis. One of these advantages is that it requires the least amount of data, another one is that its simplicity allows the inference of large size models with a higher speed of analysis. However, the resulting relational structure of the network is incomplete, for an effective biological analysis. This situation has driven us to explore the hybridization with other approaches, such as biclustering techniques. This applied technique finds new relations between the nodes of the existent GRN. In this abstract we present a new software, called GeRNeT that integrates the algorithms of GRNCOP2 and BiHEA along a set of tools for interactive visualization, statistical analysis and ontological enrichment of the resulting GRNs that it was published in Dussaut et al. [1]. In this regard, results associated with Alzheimer disease datasets are presented that show the usefulness of integrating both bioinformatics tools.Sociedad Argentina de Informática e Investigación Operativ

Neurophotonics Approaches for the Study of Pattern Separation

Successful memory involves not only remembering over time but also keeping memories distinct. Computational models suggest that pattern separation appears as a highly efficient process to discriminate between overlapping memories. Furthermore, lesion studies have shown that the dentate gyrus (DG) participates in pattern separation. However, these manipulations did not allow identifying the neuronal mechanism underlying pattern separation. The development of different neurophotonics techniques, together with other genetic tools, has been useful for the study of the microcircuit involved in this process. It has been shown that less-overlapped information would generate distinct neuronal representations within the granule cells (GCs). However, because glutamatergic or GABAergic cells in the DG are not functionally or structurally homogeneous, identifying the specific role of the different subpopulations remains elusive. Then, understanding pattern separation requires the ability to manipulate a temporal and spatially specific subset of cells in the DG and ideally to analyze DG cells activity in individuals performing a pattern separation dependent behavioral task. Thus, neurophotonics and calcium imaging techniques in conjunction with activity-dependent promoters and high-resolution microscopy appear as important tools for this endeavor. In this work, we review how different neurophotonics techniques have been implemented in the elucidation of a neuronal network that supports pattern separation alone or in combination with traditional techniques. We discuss the limitation of these techniques and how other neurophotonic techniques could be used to complement the advances presented up to this date.Fil: Morales, Cristian. Pontificia Universidad Católica de Chile; ChileFil: Morici, Juan Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; ArgentinaFil: Miranda, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; ArgentinaFil: Gallo, Francisco Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; ArgentinaFil: Bekinschtein, Pedro Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; ArgentinaFil: Weisstaub, Noelia V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; Argentin